Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population
Authors: L.M. Qin, G.M. Qin, X.H. Shi, A.L. Wang and H. Zuo
We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with contro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027632
- DOI:
- 10.4238/gmr.15027632
Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis
Authors: Y. Zhang, Y.F. Yu, J.Z. Wang and H. Jia
This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and scree.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.14
- DOI:
- 10.4238/2015.August.3.14
A single nucleotide polymorphism in the promoter region (rs10877887) of let-7 is associated with hepatocellular carcinoma in a Chinese population
Authors: Z.Y. Sui, J. Li, G.L. Cheng and S.F. Wang
Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027661
- DOI:
- 10.4238/gmr.15027661
Role of adiponectin in adipose tissue wound healing
Authors: C.E. Jin, L. Xiao, Z.H. Ge, X.B. Zhan and H.X. Zhou
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.11
- DOI:
- 10.4238/2015.August.3.11
Expression and variation of Myf5 and MyoD1 genes in different tissues of Wuzhishan pigs
Authors: G.Y. Hou,H.L. Zhou,T. Cao,W.J. Xun,D.J. Wang,L.G. Shi,S. Guan,D.F. Wang and M. Li
The myogenic regulatory factor (MRF) family includes Myf5, MyoD1, Myf4, and Mfy6 genes. This experiment assessed the variation of Myf5 and MyoD1 genes from birth to maturity (30, 210, and 360 days) in the back muscle tissue of Wuzhishan pigs (WZSP), and the expression of Myf5 and MyoD1 mRNA in the heart, liver, lung, spleen, kidney, muscle, stomach, and i.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.22
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.22
Identification of altered pathways in hypertrophic cardiomyopathy based on combined data of protein-protein interactions and molecular pathways
Authors: S.W. Zhang, J. Wang and J. Pan
The purpose of our study was to identify molecular pathways altered during the pathogenesis of hypertrophic cardiomyopathy (HCM) based on data from the STRING protein-protein interaction (PPI) database and the REACTOME pathway database. Identification of differentially expressed genes (DEGs) was carried out, followed by constr.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027754
- DOI:
- 10.4238/gmr.15027754
Effect of HIF-1a/VEGF signaling pathway on plasma progesterone and ovarian prostaglandin F2a secretion during luteal development of pseudopregnant rats
Authors: X.Y. Pan, Z.H. Zhang, L.X. Wu and Z.C. Wang
The corpus luteum is a temporary endocrine structure in mammals that plays an important role in the female reproductive cycle and is formed from a ruptured and ovulated follicle with rapid angiogenesis. Vascular endothelial growth factor (VEGF) is thought to be vital in normal and abnormal angiogenesis in the ovary, but the molecular regulation of luteal .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.3
- DOI:
- 10.4238/2015.August.3.3
Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer
Authors: J.Y. Gu and L. Tu
Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027839
- DOI:
- 10.4238/gmr.15027839
Adeno-associated virus-mediated BMP-7 and SOX9 in vitro co-transfection of human degenerative intervertebral disc cells
Authors: X.F. Ren, Z.Z. Diao,Y.M. Xi,Z.H. Qi,S. Ren,Y.J. Liu,D.L. Yang,X. Zhang and S.L. Yuan
Bone morphogenetic protein-7 (BMP-7) and SOX9 are important transcription factors in chondrogenesis. In this study, we examined the biological function of the adeno-associated virus (AAV)-mediated BMP-7 and SOX9 double gene in vitro co-transfection of nucleus pulposus cells of human degenerative intervertebral disc. Human intervertebral disc nucleus pulpo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.1
Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease
Authors: Z.P. Yan, X. Tong, S.T. Liu, Y. Ma, S.F. Peng, X. Yang and H. Fan
Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value. W.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027854
- DOI:
- 10.4238/gmr.15027854