Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China
Authors: H. Sun, Z.Q. Yang, S.Y. Liu, L. Yu, K. Huang, K.Q. Lin, J.Y. Chu and X.Q. Huang
Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hypertension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have different origins and are subjected to .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.2
- DOI:
- 10.4238/2015.August.3.2
Protein expression levels in the medullary visceral zone of rats with subarachnoid hemorrhage
Authors: L.H. Sun, L.F. Xing, G.H. Zhang and S.Y. Pan
We investigated protein expression in the medullary visceral zone (MVZ) of rats with multiple-organ dysfunction syndrome (MODS) caused by subarachnoid hemorrhage (SAH) to discuss the possible regulatory mechanism of the MVZ in the course of SAH-induced MODS. A SAH-induced MODS model was established in rats by injecting arterial blood into the Willis&rsquo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.7
- DOI:
- 10.4238/2015.August.3.7
Characterization and expression analysis of the prophenoloxidase activating factor from the mud crab Scylla paramamosain
Authors: J. Wang, K.J. Jiang, F.Y. Zhang, W. Song, M. Zhao, H.Q. Wei, Y.Y. Meng and L.B. Ma
Prophenoloxidase activating factors (PPAFs) are a group of clip domain serine proteinases that can convert prophenoloxidase (pro-PO) to the active form of phenoloxidase (PO), causing melanization of pathogens. Here, two full-length PPAF cDNAs from Scylla paramamosain (SpPPAF1 and SpPPAF2) were cloned and characterized. The full-length SpPPAF1 cDNA was 167.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.8
- DOI:
- 10.4238/2015.August.3.8
Feasibility of comfortable and secure intubation achieved with the Disposcope endoscope or Macintosh laryngoscope for patients in whom glottis viewing is difficult
Authors: X.-H. Li,Z. Sun and L.-L. He
We aimed to study the feasibility of a comfortable and secure intubation achieved with the Disposcope endoscope or Macintosh laryngoscope when glottis viewing is difficult. Forty adults scheduled for elective surgery under general anesthesia, in whom glottis viewing was difficult with the Macintosh laryngoscope (classified as Cormack-Lehane Grade III or I.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.19
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.19
Characterization and effects of miR-21 expression in esophageal cancer
Authors: S.-W. Wen, Y.-F. Zhang, Y. Li, Z.-X. Liu, H.-L. Lv, Z.-H. Li, Y.-Z. Xu, Y.-G. Zhu and Z.-Q. Tian
The aim of this study was to investigate the expression of miR-21 in esophageal cancer and the impact of miR-21 on apoptosis, invasion, and the expression of target genes in esophageal cancer cells. Fluorescence quantitative polymerase chain reaction analysis was used to detect the expression of miR-21 in human esophageal tissues, adjacent tissues, and an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.4
- DOI:
- 10.4238/2015.August.3.4
A comparative study of stress-related gene expression under single stress and intercross stress in rice
Authors: Y.P. Zhang, Z.G. E,H. Jiang,L. Wang,J. Zhou and D.F. Zhu
Plant hormones play important roles in the crosstalk between biotic and abiotic stresses in rice throughout its entire growth period. However, these interactions are not completely understood. In this study, the physiological performance of rice seedlings under a single stress and a sequential combination of various stresses (intercross stress) was determ.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.20
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.20
Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes
Authors: J. Wang, T. Zou, H.X. Yang, Y.Z. Gong, X.J. Xie, H.Y. Liu and D.F. Liao
Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.5
- DOI:
- 10.4238/2015.August.3.5
Prediction of core cancer genes using a hybrid of feature selection and machine learning methods
Authors: Y.X. Liu, N.N. Zhang, Y. He and L.J. Lun
Machine learning techniques are of great importance in the analysis of microarray expression data, and provide a systematic and promising way to predict core cancer genes. In this study, a hybrid strategy was introduced based on machine learning techniques to select a small set of informative genes, which will lead to improving classification accuracy. Fi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.10
- DOI:
- 10.4238/2015.August.3.10
Attenuated mRNA expression of lipid metabolism genes in primary hepatocytes following lipopolysaccharide treatment in dairy cows
Authors: Y.Y. Wang, H.P. Li, X.J. Wang,Q.D. Jiang,J. Geng,L.F. Wang,Y.J. Guo,W.F. Lu,H.S. Zhu and G.Y. Yang
The influence of ruminal acidosis on ruminal microbiology and metabolite production has received considerable attention, but little is known regarding the systemic manifestations that arise from ruminal acidosis. Lipopolysaccharide (LPS) is released in the gastrointestinal tract upon ingestion of high-grain or high-fat diets, and it has been implicated in.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.21
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.21
Effect of montelukast on the expression of interleukin-18, telomerase reverse transcriptase, and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage
Authors: J.L. Liu, X.H. Zhao, D.L. Zhang, J.B. Zhang and Z.H. Liu
The aim of this study was to investigate the effect of montelukast on the expression of interleukin (IL)-18, telomerase reverse transcriptase (TERT), and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage (HIBD). To establish the model of HIBD, 8% oxygen was applied to rats after the unilateral carotid artery was ligated. Twenty.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.13
- DOI:
- 10.4238/2015.August.3.13