Expression of TNF-�±, VEGF, and MMP-3 mRNAs in synovial tissues and their roles in fibroblast-mediated osteogenesis in ankylosing spondylitis
Authors: K.G. Liu, Q.H. He, J.W. Tan and G.J. Liao
The aim of this study was to explore the mRNA levels of tumor necrosis factor-α (TNF-α), vessel endothelial growth factor (VEGF), and matrix metalloproteinase-3 (MMP-3) in synovial tissues in ankylosing spondylitis (AS), and to analyze the functions of these proteins in the differentiation of AS synovial tissue fibroblasts into osteoblasts (OB.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.28
- DOI:
- 10.4238/2015.June.18.28
Identification of sequence-related amplified polymorphism markers linked to the red leaf trait in ornamental kale (Brassica oleracea L. var. acephala)
Authors: Y.S. Wang, Z.Y. Liu, Y.F. Li, Y. Zhang, X.F. Yang and H. Feng
Artistic diversiform leaf color is an important agronomic trait that affects the market value of ornamental kale. In the present study, genetic analysis showed that a single-dominant gene, Re (red leaf), determines the red leaf trait in ornamental kale. An F2 population consisting of 500 individuals from the cross of a red leaf double-haploid line â.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.3
- DOI:
- 10.4238/2013.April.2.3
Association between a point mutation at the -743-bp region of the transthyretin (TTR) gene and familial vitreous amyloidosis
Authors: X.M. Nie, S.J. Cai, B. Xie, X.W. Chen and M. Jiang
The aim of this study was to identify changes in the base sequence of the upstream regulatory region of the transthyretin (TTR) gene. Whole-blood DNA was extracted from ten subjects belonging to a family with familial amyloidosis vitreoretinopathy; the upstream regulatory sequence was amplified by polymerase chain reaction, detected by gel electrophoresis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016926
- DOI:
- 10.4238/gmr.15016926
Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis
Authors: R.T. Sun, W.J. Tian, X.W. Xing, S.H. Gao and S.B. Wang
The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1β rs16944, IL8 r.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.29
- DOI:
- 10.4238/2015.June.18.29
Effect of two single nucleotide polymorphisms on milk yield and composition
Authors: J.C. Rinc�³n, A. L�³pez-Herrera and J.J. Echeverri
The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and some economically important character.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.15
- DOI:
- 10.4238/2013.April.2.15
Apomixis in cassava: advances and challenges
Authors: D.Y.H. Freitas and N.M.A. Nassar
Cassava is the most important staple crop in the Tropics and Subtropics. Apomixis may revolutionize its production due to various attributes. These potential advantages include production by true seed, maintaining cultivar superiority over generations without segregation, and avoiding contamination by bacteria and viruses. Historically, apomixis was initi.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.14
- DOI:
- 10.4238/2013.April.2.14
Intracranial aneurysm risk factor genes:relationship with intracranial aneurysm risk in a Chinese Han population
Authors: L.T. Zhang, F.J. Wei, Y. Zhao, Z. Zhang, W.T. Dong, Z.N. Jin, F. Gao, N.N. Gao, X.W. Cai, N.X. Li, W. Wei, F.S. Xiao, S.Y. Yue, J.N. Zhang, S.Y. Yang, W.D. Li and X.Y. Yang
Few studies have examined the genes related to risk factors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression mod.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.30
- DOI:
- 10.4238/2015.June.18.30
Genetic analysis of differentiation of T-helper lymphocytes
Authors: Q. Wang, M. Li, L.C. Xia, G. Wen, H. Zu and M. Gao
In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3. We developed a system dynamics mod.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.13
- DOI:
- 10.4238/2013.April.2.13
Cytogenetic analysis of Triatoma pseudomaculata CorrÃ?ªa and EspÃ?Ânola, 1964 (Hemiptera, Triatominae) from different Brazilian states
Authors: C.H.L. Imperador, K.C.C. Alevi, J. Oliveira, J.A. Rosa and M.T.V. Azeredo-Oliveira
Triatoma maculata and T. pseudomaculata are allopatric; however, it is believed that T. maculata was introduced into the Brazilian northeast by passive transportation of the nymphs between the feathers of migratory birds, followed by the speciation of T. pseudomaculata. T. pseudomaculata is the second most epidemiologically important species in the northe.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016937
- DOI:
- 10.4238/gmr.15016937
Investigation of Sclerotinia sclerotiorum strains variability in Brazil
Authors: M.J. Abreu and E.A. Souza
White mold is a common bean disease caused by the fungus Sclerotinia sclerotiorum, resulting in economic losses in Brazil and worldwide. Lack of knowledge about the population structure of the pathogen makes it difficult to control the disease. The aim of this study was to characterize strains of S. sclerotiorum obtained from experimental and commercial c.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.31
- DOI:
- 10.4238/2015.June.18.31