Initial assessment of natural diversity in Mexican fig landraces
Authors: M.T. Garc�?a-Ruiz, V.M. Mendoza-Castillo, E. Valadez-Moctezuma and A. Muratalla-L�?ºa
The common fig (Ficus carica L.) was introduced into Mexico by Spanish Franciscan missionaries in the 16th century. It is widely assumed that Mexican figs are the Spanish cultivar Black Mission. We collected and propagated 12 fig plants from six landraces from different states in Central Mexico that represent different climate. All of them were grown in a.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.12
- DOI:
- 10.4238/2013.September.23.12
Partial least squares-based gene expression analysis in preeclampsia
Authors: F. Jiang, Y. Yang, J. Li, W. Li, Y. Luo, Y. Li, H. Zhao, X. Wang, G. Yin and G. Wu
Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.2
- DOI:
- 10.4238/2015.June.18.2
Positive evolution of the glycoprotein (GP) gene is related to transmission of the Ebola virus
Authors: Y.X. Jing, L.N. Wang, X.M. Wu and C.X. Song
Ebola hemorrhagic fever is a fatal disease caused by the negative-strand RNA of the Ebola virus. A high-intensity outbreak of this fever was reported in West Africa last year; however, there is currently no definitive treatment strategy available for this disease. In this study, we analyzed the molecular evolutionary history a.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017173
- DOI:
- 10.4238/gmr.15017173
Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians
Authors: J. Liu, H.X. Zhang, G.Y. Feng and L. He
We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.11
- DOI:
- 10.4238/2013.September.23.11
Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was p.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.10
- DOI:
- 10.4238/2013.September.23.10
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease
Authors: Y.Y. Chen, B.N. Wang and X.P. Yu
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An addit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017238
- DOI:
- 10.4238/gmr.15017238
Conservation genetics of Annamocarya sinensis (Dode) Leroy, an endangered endemic species
Authors: Z.Y. Zhang, X.M. Pang, J.W. Han, Y. Wang and Y.Y. Li
The endangered perennial plant Annamocarya sinensis (Dode) Leroy is a tertiary relict tree restricted to southeastern China and northern Vietnam. To explore endangerment mechanisms, develop protection strategies, and guide reintroduction efforts for this species, we investigated genetic diversity and population structure by surveying 70 individuals from t.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.9
- DOI:
- 10.4238/2013.March.11.9
Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer
Authors: E. Aynaci, E. Coskunpinar, A. Eren, O. Kum, Y.M. Oltulu, N. Akkaya, A. Turna, I. Yaylim and P. Yildiz
Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.9
- DOI:
- 10.4238/2013.February.28.9
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome
Authors: V.R.A. Vargas, S.L. Bonatto, F.E. Macagnan, A.M.P. Feoli, C.S. Alho, N.D.V. Santos and V.M. Schmitt
We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.8
- DOI:
- 10.4238/2013.February.28.8