Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease
Authors: E.M. Merzetti and B.E. Staveley
F-box proteins act as the protein recognition component of the Skp-Cul-F-box class of ubiquitin ligases. Two members of a gene sub-family encoding these proteins, FBXO7 and FBXO32, have been implicated in the onset and progression of degenerative disease. FBXO7 is responsible for rare genetic forms of Parkinson disease, while .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028579
- DOI:
- 10.4238/gmr.15028579
Bovine herpesvirus type 5 infection regulates Bax/BCL-2 ratio
Authors: A.F. Garcia, J.B. Novais, T.F. Antello, C. Silva-Frade, M.C. Ferrarezi, E.F. Flores and T.C. Cardoso
Bovine herpesvirus 5 (BoHV-5) is an α-herpesvirus that causes neurological disease in young cattle and is also occasionally involved in reproductive disorders. Although there have been many studies of the apoptotic pathways induced by viruses belonging to the family Herpesviridae, there is little information about the intrinsic programmed cell death.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.8
- DOI:
- 10.4238/2013.September.23.8
Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice
Authors: D.C.S. Lima, C.R. Silva, B.L. Sampaio, J.R. de Paula and L. Chen-Chen
Lafoensia pacari (Lythraceae), popularly known in Brazil as “pacari”, is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.7
- DOI:
- 10.4238/2013.September.23.7
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
Authors: L. Luo, D.H. Li, S.G. Wei, H.B. Zhang, S.B. Li and J. Zhao
Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are contr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.6
- DOI:
- 10.4238/2013.September.23.6
Bean (Phaseolus vulgaris L.) lines: chemical composition and protein digestibility
Authors: F.R. Mesquita, M.I.A. Silva and A.D. Corr�ªa
The bean represents the main source of proteins for the low income populations, although the digestibility of those proteins is relatively low. Consequently, the programs of plant genetic breeding have been working on the search for new lines with higher protein levels. Thus, with the purpose of supplying information to the re.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028587
- DOI:
- 10.4238/gmr.15028587
Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla
Authors: Q.-B. Zhang, W. Cao, Y.-R. Liu, S.-M. Cui and Y.-Y. Yan
The function of SIRT1 in the proliferation and osteoblastic differentiation of dental stem cells is unclear. The aim of this study was to assess the roles of SIRT1 in these processes using periodontal ligament stem cells (PDLSCs) and stem cells from apical papilla (SCAPs). A defined concentration of resveratrol, an SIRT1 activ.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15015234
- DOI:
- 10.4238/gmr.15015234
Development of highly polymorphic EST-SSR markers and segregation in F1 hybrid population of Vitis vinifera L.
Authors: E. Kayesh, Y.Y. Zhang, G.S. Liu, N. Bilkish, X. Sun, X.P. Leng and J.G. Fang
The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between “Early Rose” and “Red Globe” were studied... Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.5
- DOI:
- 10.4238/2013.September.23.5
Cytogenetic toxicity and gonadal effects of 17 �±-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae)
Authors: C.L.G. Rivero-Wendt, A.L. Miranda-Vilela, M.F.N. Ferreira, A.M. Borges and C.K. Grisolia
The synthetic hormone, 17-α-methyltestosterone (MT), is used in fish hatcheries to induce male monosex. Androgenic effects on various fish species have been reported; however, few studies have assessed possible genotoxic effects, although there are concerns about such effects in target and non-target species. We evaluated genotoxic and gonadal effec.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.4
- DOI:
- 10.4238/2013.September.23.4
Mixture of polysaccharide and nucleic acid extracted from Bacillus Calmette-Guerin (BCG) enhances immune response of infectious bursal disease virus vaccine in chickens
Authors: X.B. Wang, Z.J. Liu, Y.J. Lv, Y. Long and E.D. Bao
In this study, the immune response induced by a mixture of polysaccharide and nucleic acid extracted from Bacillus Calmette-Guerin (BCG) was evaluated in chickens inoculated with infectious bursal disease virus (IBDV) vaccine. After the mixture was injected intramuscularly at a dose of 0.075, 0.15 or 0.3 mg·kg-1·.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025523
- DOI:
- 10.4238/gmr.15025523
Insights into a hotspot in the Brasiliensis subcomplex (Hemiptera, Triatominae) by analysis of D2 domain of the nuclear gene 28S
Authors: A.L. Guerra1, K.C.C. Alevi1, C.A. Banho2, J. Oliveira3, J.A. Rosa3 and M.T.V. Azeredo-Oliveira1
The Brasiliensis subcomplex is a monophyletic group formed by the species Triatoma brasiliensis brasiliensis, T. b. macromelasoma, T. juazeirensis, T. melanica, and T. sherlocki. However, using cytogenetic data and experimental hybrid crosses, T. lenti and T. petrochiae were also grouped into this subcomplex. This study aims t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017449
- DOI:
- 10.4238/gmr.15017449