Agrobacterium-mediated transformation of the �²-subunit gene in 7S globulin protein in soybean using RNAi technology
Authors: J. Qu, S.Y. Liu, P.W. Wang, S.Y. Guan, Y.G. Fan, D. Yao, L. Zhang and J.L. Dai
The objective of this study was to use RNA interference (RNAi) to improve protein quality and decrease anti-nutritional effects in soybean. Agrobacterium tumefaciens-mediated transformation was conducted using RNAi and an expression vector containing the 7S globulin β-subunit gene. The BAR gene was used as the selective m.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027561
- DOI:
- 10.4238/gmr.15027561
TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis
Authors: X.P. Lu, G.N. Hu, J.Q. Du and H.Q. Li
Numerous studies have evaluated the association between TCF7L2 gene polymorphisms (rs12255372 and rs7903146) and breast cancer risk. However, the results have been inconsistent. Therefore, in the current study, we performed a meta-analysis. A systematically literature search of the PubMed and EMBASE databases was conducted in November 2013, and the refere.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.16
- DOI:
- 10.4238/2015.March.31.16
Polymorphisms in the LPL gene and their association with growth traits in Jiaxian cattle
Authors: L.S. Gui, Y.M. Huang, J.Y. Hong and L.S. Zan
Previous studies showed that the lipoprotein lipase (LPL) gene was involved in metabolism and transport of lipids, suggesting that the LPL is a potential candidate gene affecting growth traits in animals. The aim of this study was to identify polymorphism in the bovine LPL gene and analyze its possible association with growth .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027590
- DOI:
- 10.4238/gmr.15027590
Methylation differences and expression profiles of the caprine DIO3 gene
Authors: H. Zhang, P.F. Jin, L.L. Niu, L. Li, L.J. Wang, Y. Chen, G.J. Zhang, H.P. Zhang and T. Zhong
DIO3 gene encoding type 3 iodothyronine deiodinase is an imprinted gene, located in the DLK1-DIO3 (delta-like 1 homolog-type 3 iodothyronine deiodinase) imprinted domain, and is potentially involved in degrading excessive amounts of thyroid hormone to protect embryogenesis. However, the underlying regulatory mechanism of the imprinted DIO3 gene expression.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038678
- DOI:
- 10.4238/gmr.15038678
Isolation and characterization of polymorphic DNA microsatellite loci for Anopheles triannulatus sensu lato (Diptera: Culicidae) and cross-amplification in congeneric species
Authors: P.F. Cruz, J.S. Batista, K.M. Formiga, M.S. Rafael, W.P. Tadei and J.M.M. Santos
Anopheles (Nyssorhynchus) triannulatus is a complex of 3 species. Thirteen polymorphic microsatellite loci were isolated and characterized in 20 to 25 individuals from Manaus (AM, Brazil). The number of alleles per locus varied from 3 to 10 (mean = 6.0). The observed heterozygosity ranged from 0.250 to 0.875 (mean = 0.680) and expected heterozygosity rang.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.13.11
- DOI:
- 10.4238/2013.March.13.11
Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk
Authors: C.X. Zhou and J.H. Zhao
Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We s.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.31.17
- DOI:
- 10.4238/2015.March.31.17
Altered expression of metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cervical disc herniation patients
Authors: H.M. Zhuang, G.T. Xu, S.F. Wen, Y.Y. Guo and Q. Huang
The aim of the current study was to examine matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in patients with cervical disc herniation (CDH). A total of 127 specimens from CDH patients undergoing posterior spinal surgery were obtained for the case group, which was divided into .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027594
- DOI:
- 10.4238/gmr.15027594
Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis
Authors: C.Q. Yi, C.H. Ma, Z.P. Xie, Y. Cao, G.Q. Zhang, X.K. Zhou and Z.Q. Liu
Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.3
- DOI:
- 10.4238/2013.March.11.3
Identification of altered pathways in Down syndrome-associated congenital heart defects using an individualized pathway aberrance score
Authors: Y.Q. Chen, T. Li, W.Y. Guo, F.J. Su and Y.X. Zhang
The aim of this study was to identify disrupted pathways related to Down syndrome (DS), and DS-associated congenital heart defects (DS-CHD). The gene expression profile and pathway data of 10 human DS patients and 5 control samples in E-GEOD-1789 were recruited and analyzed by the individualized pathway aberrance score (iPAS) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027601
- DOI:
- 10.4238/gmr.15027601
A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil
Authors: A.V.C. Coelho, R.R. Moura, C.A.J. Cavalcanti, R.L. Guimar�£es,P. Sandrin-Garcia, S. Crovella and L.A.C. Brand�£o
Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples&rsquo.. Read More»
- Genet. Mol. Res. 14(1):