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Human Genetics   Research Article

New efficient DNA extraction method to access the microbiome of Ricinus communis seeds

Authors: C.D. Santos Jr., A.C.C. Dias, I.M.R. Amaral, A.M. Bonetti and T.A. Campos

Ricinus communis (castor bean) seeds are used to produce an alcohol-soluble oil that is used in more than 400 industrial processes. Despite its economic importance, there has been little research on the endophytic microbiota of castor bean seeds. This microbiota is important for plant metabolic processes and may have considerable biotechnological potentia.. Read More»

Genet. Mol. Res. 12(3):
2013.February.28.23
DOI:
10.4238/2013.February.28.23
Animal Genetics   Research Article

Adaptive evolution of the mitochondrial ND6 gene in the domestic horse

Authors: T. Ning, H. Xiao, J. Li, S. Hua and Y.P. Zhang

Mitochondria play a crucial role in energy metabolism through oxidative phosphorylation. Organisms living at high altitudes are potentially influenced by oxygen deficits and cold temperatures. The severe environmental conditions can impact on metabolism and direct selection of mitochondrial DNA. As a wide-ranging animal, the d.. Read More»

Genet. Mol. Res. 9(1):
vol9-1gmr705
DOI:
10.4238/vol9-1gmr705
Medical Genetics   Research Article

Genetic diversity analysis of Varronia curassavica Jacq. accessions using ISSR markers

Authors: F.A. Brito, D.A.C. Nizio, A.V.C. Silva2 L.E.C. Diniz, A.R.C. Rabbani, M.F. Arrigoni-Blank, S.V. Alvares-Carvalho, G.M. Figueira, I. Montanari J�ºnior and A.F. Blank

Varronia curassavica Jacq. is a medicinal and aromatic plant from Brazil with significant economic importance. Studies on genetic diversity in active germplasm banks (AGB) are essential for conservation and breeding programs. The aim of this study was to analyze the genetic diversity of V. curassavica accessions of the AGB of Medicinal and Aromatic Plants.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038681
DOI:
10.4238/gmr.15038681
Animal Genetics   Research Article

Interactions of allele E of the MC1R gene with FM and mutations in the MLPH gene cause the five-gray phenotype in the Anyi tile-like gray chicken

Authors: J.G. Xu, M.G. Xie, S.Y. Zou, X.F. Liu, X.H. Li1, J.F. Xie and X.Q. Zhang

The Anyi tile-like gray chicken is a Chinese indigenous breed with a gray dilution phenotype, having gray feathers, comb, skin, shanks, and beak, which is valuable for genetic research on pigmentation. However, the genetic basis of the gray dilution phenotype remains unknown. The objective of this study was to investigate the .. Read More»

Genet. Mol. Res. 15(2):
gmr.15027633
DOI:
10.4238/gmr.15027633
Cytogenomics   Research Article

CASP-9 gene functional polymorphisms and cancer risk: a large-scale association study plus meta-analysis

Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu

We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% c.. Read More»

Genet. Mol. Res. 12(3):
2013.February.28.22
DOI:
10.4238/2013.February.28.22
Animal Genetics   Research Article

Microarray analysis of differentially expressed genes in the liver between Bai�er layers and broilers

Authors: Q.-G. Wang , H.-F. Zhang, S.-Z. Wang, G.L. Gao, L. Leng, W. Na and H. Li

In this study, we profiled gene expression in chicken liver and screened differentially expressed genes in the Bai’er layers and fat line broilers. Birds were derived from the 14th generation of Northeast Agricultural University fat broiler lines and Bai’er layers. Chicken genome arrays were used to screen differentially expressed genes in liv.. Read More»

Genet. Mol. Res. 14(1):
2015.March.31.19
DOI:
10.4238/2015.March.31.19
Human Genetics   Research Article

Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism

Authors: M.D. Martello, N. David, R. Matuo, P.C. Carvalho, S.D. Navarro,A.C.D. Monreal, A.L. Cunha-Laura, C.A.L. Cardoso, C.A.L. Kassuya and R.J. Oliveira

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic .. Read More»

Genet. Mol. Res. 15(2):
gmr.15027678
DOI:
10.4238/gmr.15027678
Human Genetics   Research Article

Ring chromosome instability evaluation in six patients with autosomal rings

Authors: C.P. Sodr�©, R.S. Guilherme, V.F.A. Meloni, D. Brunoni, Y. Juliano, J.A.D. Andrade, S.I.N. Belangero, D.M. Christofolini, L.D. Kulikowski and M.I. Melaragno

Ring chromosomes are often associated with abnormal phenotypes due to loss of genomic material and also because of ring instability at mitosis after sister chromatid exchange events. We investigated ring chromosome instability in six patients with ring chromosomes 4, 14, 15, and 18 by examining 48- and 72-h lymphocyte cultures.. Read More»

Genet. Mol. Res. 9(1):
vol9-1gmr707
DOI:
10.4238/vol9-1gmr707
Animal Genetics   Research Article

Diagnosis and epidemiology of canine leishmaniasis in southeastern Bahia, Brazil

Authors: T.N.A. Oliveira, P.E.B. Guedes, G.B. Souza, F.S. Carvalho, R.S. Alberto Carlos G.R. Albuquerque, A.D. Munhoz and F.L. Silva

Leishmaniasis is a disease caused by protozoa of the genus Leishmania. Two distinct forms are recognized: visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). In the Americas, the causative agent of VL is L. infantum chagasi, whereas L. braziliensis is principally responsible for CL. Domestic dogs constitute the main .. Read More»

Genet. Mol. Res. 15(3):
gmr.15038684
DOI:
10.4238/gmr.15038684
Human Genetics   Research Article

Structure and immune expression analysis of hemoglobin genes from the blood clam Tegillarca granosa

Authors: Y.B. Bao, Q. Wang, X.M. Guo and Z.H. Lin

Hemoglobin (Hb) is the major protein component of erythrocytes in animals with red blood, although it can serve additional functions beyond the transport of oxygen. The blood clam (Tegillarca granosa) is one of the few mollusks that has Hb, although the structure and function of molluskan Hbs remain unclear. We characterized two unique and highly compartm.. Read More»

Genet. Mol. Res. 12(3):
2013.February.28.5
DOI:
10.4238/2013.February.28.5