PANNOTATOR: an automated tool for annotation of pan-genomes
Authors: A.R. Santos, E. Barbosa, K. Fiaux, M. Zurita-Turk, V. Chaitankar, B. Kamapantula, A. Abdelzaher, P. Ghosh, S. Tiwari, N. Barve, N. Jain, D. Barh, A. Silva, A. Miyoshi and V. Azevedo
Due to next-generation sequence technologies, sequencing of bacterial genomes is no longer one of the main bottlenecks in bacterial research and the number of new genomes deposited in public databases continues to increase at an accelerating rate. Among these new genomes, several belong to the same species and were generated for pan-genomic studies. A pan.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.16.2
- DOI:
- 10.4238/2013.August.16.2
Analysis of FKBP10, SERPINH1, and SERPINF1 genes in patients with osteogenesis imperfecta
Authors: C. Barbirato, M. Trancozo, M.R.G.O. Rebou�§as, V. Sipolatti, V.R.R. Nunes and F. Paula
Osteogenesis imperfecta (OI) is a heterogeneous disorder that causes fragility, deformity, and fractures in bones. A large number of genes that are associated with the disease have been identified in the last decade; this makes the genetic diagnosis of OI more difficult. To improve our knowledge of the genetic mutation profile.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038665
- DOI:
- 10.4238/gmr.15038665
Additive genetic relationship of longevity with fertility and production traits in Nellore cattle based on bivariate models
Authors: M.H. Van Melis, H.N. Oliveira, J.P. Eler, J.B.S. Ferraz, J. Casellas and L. Varona
Survival or longevity is an economically important trait in beef cattle. The main inconvenience for its inclusion in selection criteria is delayed recording of phenotypic data and the high computational demand for including survival in proportional hazard models. Thus, identification of a longevity-correlated trait that could .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr710
- DOI:
- 10.4238/vol9-1gmr710
Presence of chromatoid bodies in the Rhodnius genus detected by cytochemical analysis
Authors: K.C.C. Alevi, N.F.C. Castro, J. Oliveira, J.A. Rosa and M.T.V. Azeredo-Oliveira
In addition to the epidemiological importance regarding the transmission of Chagas disease, triatomines are also important biological models for cellular studies, because they have holocentric chromosomes, post-reductional meiosis for sex chromosomes, and nucleolar persistence. Although the nucleolus is present during spermiog.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027978
- DOI:
- 10.4238/gmr.15027978
Mixed inheritance in the genetic control of ramulosis (Colletotrichum gossypii var. cephalosporioides) resistance in cotton
Authors: M.A.C. Oliveira, J.B. Duarte, C.L. Morello, N.D. Suassuna and A.B. Oliveira
Ramulosis is one of the most aggressive diseases in cotton, and understanding the genetic control of its resistance is imperative for selecting superior cotton genotypes in breeding programs. This study analyzed the inheritance pattern of this resistance using chi-square goodness-of-fit tests to determine the phenotypic proportions of the F2 generation, and .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038667
- DOI:
- 10.4238/gmr.15038667
Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-�ºB in renal tissue of rats with diabetic nephropathy
Authors: L. Li, Y.W. Zhao, J.S. Zeng, F. Fan, X. Wang, Y. Zhou and Z. Zhu
This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-κB in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the goal of developing new clinical treatment selection for DN. Sprague-Dawley rats were randomly divided into a norm.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.16.1
- DOI:
- 10.4238/2013.August.16.1
Molecular cloning, functional verification, and evolution of TmPm3, the powdery mildew resistance gene of Triticum monococcum L.
Authors: C.Z. Zhao, Y.H. Li, H.T. Dong, M.M. Geng, W.H. Liu, F. Li, Z.F. Ni, X.J. Wang, C.J. Xie and Q.X. Sun
Powdery mildew (Pm) is one of the most harmful diseases in wheat. Three Pm-resistance genes, Pm3, Pm21, and Pm8, have been cloned but most Pm3/Pm8 alleles have lost their resistance to Pm in hexaploid wheat. In this study, a new Pm3 homolog gene (TmPm3) was isolated from Triticum monococcum L. using a homology-based cloning st.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028056
- DOI:
- 10.4238/gmr.15028056
Functional analysis of a TGA factor-binding site located in the promoter region controlling salicylic acid-induced NIMIN-1 expression in Arabidopsis
Authors: J.P. Fonseca, M. Menossi, F. Thibaud-Nissen and C.D. Town
TGA factors play a key role in plant defense by binding to the promoter region of defense genes, inducing expression. Salicylic acid (SA) induces the expression of the gene encoding NIMIN-1, which interacts with NPR1/NIM1, a key regulator of systemic acquired resistance. We investigated whether the TGA2-binding motif TGACG located upstream of the NIMIN-1 .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr704
- DOI:
- 10.4238/vol9-1gmr704
Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis
Authors: X.L. Xing, Y. Lu and H.L. Qiu
Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028085
- DOI:
- 10.4238/gmr.15028085
Microsatellite usefulness is independent of phylogenetic distance in Tyrant flycatchers (Aves: Tyrannidae): a test using two globally threatened species
Authors: B. Mahler, A.R.R. Schneider, A.S. Di Giacomo, A.G. Di Giacomo, J.C. Reboreda and R. Tiedemann
Tyrant flycatchers (Aves: Tyrannidae) are endemic to the New World, and many species of this group are threatened or near-threatened at the global level. The aim of this study was to test the 18 microsatellite markers that have been published for other Tyrant flycatchers in the Strange-tailed Tyrant (Alectrurus risora) and the Sharp-tailed Tyrant (Culiciv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.12
- DOI:
- 10.4238/2013.August.12.12