Effect of polychlorinated biphenyls on oxidation stress in the liver of juvenile GIFT, Oreochromis niloticus
Authors: Y. Zheng, L.P. Qiu, S.L. Meng, L.M. Fan, C. Song, D.D. Li, C. Zhang and J.Z. Chen
The present study clearly showed that chronic exposure to polychlorinated biphenyls (PCBs) at environmentally relevant concentrations can damage juvenile tilapia livers by modulating antioxidant enzyme activities and gene transcription, which affects toxic bioaccumulation and histological congestion. The results suggest that P.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038613
- DOI:
- 10.4238/gmr.15038613
Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer
Authors: X. Chen, X.S. Liu, H.Y. Liu, Y.Y. Lu and Y. Li
Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027702
- DOI:
- 10.4238/gmr.15027702
A novel RUNX2 mutation (T420I) in Chinese patients with cleidocranial dysplasia
Authors: G.X. Wang, R.P. Sun and F.L. Song
Cleidocranial dysplasia (CCD) is an autosomal-dominant heritable skeletal disease caused by heterozygous mutations in the RUNX2 gene. We studied a Chinese family that included three affected individuals with CCD phenotypes; the clinical features of patients with CCD include delayed closure of fontanelles, frontal bossing, dysp.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr685
- DOI:
- 10.4238/vol9-1gmr685
Identification and assessment of differentially expressed genes involved in growth regulation in Apostichopus japonicus
Authors: L. Zhu,C.H. Li, X.R. Su, C.Y. Guo, Z. Wang, C.H. Jin,Y. Li,T.W. Li
Rapid and efficient growth is a major consideration and challenge for global mariculture. The differential growth rate of the sea cucumber, Apostichopus japonicus, has significantly hampered the total production of the industry. In the present study, forward and reverse suppression subtractive hybridization libraries were constructed and sequenced from a .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.4
- DOI:
- 10.4238/2013.August.20.4
Genetic diversity in cassava landraces grown on farms in Alta Floresta-MT, Brazil
Authors: A.V. Tiago, A.A.B. Rossi, P.V. Tiago, A.A. Carpejani, B.M. Silva, E.S.S. Hoogerheide and O.M. Yamashita
Brazil is considered one of the domestication centers of cassava (Manihot esculenta), containing a large part of the biological diversity and traditional knowledge of the species. The aim of the present study was to evaluate the genetic diversity of cassava landraces grown by farmers in the north of Mato Grosso State, Brazil, .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038615
- DOI:
- 10.4238/gmr.15038615
Evaluation of candidate barcoding markers in Orinus (Poaceae)
Authors: X. Su, Y.P. Liu, Z. Chen and K.L. Chen
Orinus is an alpine endemic genus of Poaceae. Because of the imperfect specimens, high level of intraspecific morphological variability, and homoplasies of morphological characters, it is relatively difficult to delimitate species of Orinus by using morphology alone. To this end, the DNA barcoding has shown great potential in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027714
- DOI:
- 10.4238/gmr.15027714
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients
Authors: M. Taheri, F. Mahjoubi and R. Omranipour
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr669
- DOI:
- 10.4238/vol9-1gmr669
Skeletal muscle calcium channel ryanodine and the development of pale, soft, and exudative meat in poultry
Authors: F.G. Pai�£o, L.M. Ferracin, M. Pedr�£o, T. Kato and M. Shimokomaki
The development of pale, soft, and exudative (PSE) breast fillet meat has become an economic burden for the poultry industry worldwide. PSE meat results in 1.0-1.5% loss in moisture and carcass weight, and a 2010 estimate of the Brazilian annual production put the economic loss due to PSE at over US$30 million. In the USA, PSE has caused an annual loss of.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.3
- DOI:
- 10.4238/2013.August.20.3
Effect of polychlorinated biphenyls on osmoregulatory response and apoptosis in GIFT tilapia, Oreochromis niloticus
Authors: Y. Zheng, L. Qiu, L. Fan, C. Song, S. Meng and J. Chen
In the present study, GIFT tilapia Oreochromis niloticus were exposed to polychlorinated biphenyls (PCBs) for 7, 14, and 21 days. Over the duration of the exposure, genotoxicity and the activity of Na+/K+-ATPase (NKA) and Ca+/Mg+-ATPase (CMA) were measured in the gill, kidney, and intestine, to evaluate changes in osmoregulatory response in O. niloticus. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038620
- DOI:
- 10.4238/gmr.15038620
Isolation and characterization of microsatellite markers for Eucommia ulmoides (Eucommiaceae), an endangered tree, using next-generation sequencing
Authors: W.R. Zhang, Y. Li, J. Zhao, C.H. Wu, S. Ye and W.J. Yuan
Eucommia ulmoides Oliver, a single extant species of Eucommiaceae, is an endemic dioecious tree in China. The natural resources of E. ulmoides have rapidly declined in recent years because of the over-collection of its cortex. To design a suitable protection strategy, it is necessary to develop a set of molecular markers to in.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027789
- DOI:
- 10.4238/gmr.15027789