Neuroprotective effect of Amaranthus lividus and Amaranthus tricolor and their effects on gene expression of RAGE during oxidative stress in SH-SY5Y cells
Authors: W. Amornrit and R. Santiyanont
Amaranthus plants, or spinach, are used as food sources worldwide. Amaranthus leaves are rich in antioxidant compounds, which act as free radical scavengers. Oxidative stress caused by the aberrant production of reactive oxygen species (ROS) represents an important mechanism for neuronal dysfunction and cell loss in different .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027562
- DOI:
- 10.4238/gmr.15027562
Mapping of major quantitative trait loci for economic traits of silkworm cocoon
Authors: Z. Lie, L. Cheng, D. Fang-yin and F. Shou-min
The quantitative trait loci (QTLs) associated with cocoon traits in silkworms were mapped in 44 individuals of a backcross of Dazao females with hybrid F1 males; the hybrid males were from females of inbred C100 strain, which have white cocoons and superior cocoon traits, crossed with males of inbred strain Dazao, which have g.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr676
- DOI:
- 10.4238/vol9-1gmr676
Genetic analysis of oocyte and embryo production traits in Guzer�¡ breed donors and their associations with age at first calving
Authors: B.C. Perez, M.G.C.D. Peixoto, F.T. Bruneli, P.V.B. Ramos and J.C.C. Balieiro
The objective of this study was to estimate variance components for oocyte and embryo production traits in Guzerá breed female donors, and investigate their associations with age at first calving (AFC). The traits analyzed were the number of viable oocytes (NOV), the number of grade I oocytes (NGI), the number of cleave.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027583
- DOI:
- 10.4238/gmr.15027583
Relationship between cytokine gene polymorphisms and acute rejection following liver transplantation
Authors: X.X. Zhang, R.J. Bian, J. Wang and Q.Y. Zhang
Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphism.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027599
- DOI:
- 10.4238/gmr.15027599
Modulatory effect of Byrsonima verbascifolia (Malpighiaceae) against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Authors: D.M. Mendanha, H.D. Ferreira, L.P. FelÃ?Âcio, E.M. Silva, D.G. Pereira, W.B. Nunes and S. Carvalho
Byrsonima verbascifolia, popularly known in Brazil as murici, is a medicinal plant widely used in the treatment of bacterial and viral infections, Chagas’s disease, diarrhea, bronchitis, cough and fever, as well as for protection of the intestinal mucosa. Since chemotherapy and radiotherapy, broadly employed in the treat.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr678
- DOI:
- 10.4238/vol9-1gmr678
Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients
Authors: A. Maver, I. Medica, B. Salobir, M. Tercelj and B. Peterlin
Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology a.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr682
- DOI:
- 10.4238/vol9-1gmr682
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis
Authors: Y. Yang, Y.Y. Luo, S. Wu, Y.D. Tang, X.D. Rao, L. Xiong, M. Tan, M.Z. Deng and H. Liu
Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of Pub.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027631
- DOI:
- 10.4238/gmr.15027631
DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase
Authors: M. Brendel, G. Marisco, I. Ganda, R. Wolter and C. Pungartnik
Blocking aldehyde dehydrogenase with the drug disulfiram leads to an accumulation of intracellular acetaldehyde, which negatively affects the viability of the yeast Saccharomyces cerevisiae. Mutants of the yeast gene PSO2, which encodes a protein specific for repair of DNA interstrand cross-links, showed higher sensitivity to .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr695
- DOI:
- 10.4238/vol9-1gmr695
Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients
Authors: H.X. Peng, X. Xu, R. Yang, Y.M. Chu, D.M. Yang, Y. Xu, F.L. Zhou, W.Z. Ma, X.J. Zhang, M. Guan, Z.H. Yang and Z.D. Jin
Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese pati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027689
- DOI:
- 10.4238/gmr.15027689
MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation
Authors: W. Peng, Z.-Y. Chen, L. Wang, Z. Wang and J. Li
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.5
- DOI:
- 10.4238/2013.August.20.5