Analysis of key genes and pathways involved in acute lung injury in a mouse model
Authors: Q.H. Han, N. Han, Y.Z. Liu, Q.H. Jin, Q.Y. Lu and Z.C. Li
A mouse model of acute lung injury (ALI) was chosen in this study to explore the key genes and pathways involved in the process of ALI with microarray technology. Gene expression microarray data were downloaded from the Gene Expression Omnibus database. Mice from the experimental group were further divided into 6 subgroups, wh.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.18.1
- DOI:
- http://dx.doi.org/10.4238/2014.June.18.1
Genetic diversity and population structure of Fenneropenaeus penicillatus determined by mitochondrial DNA analyses
Authors: Y.Y. Cao and Z.B. Li
Fenneropenaeus penicillatus is a widely distributed economically and ecologically important shrimp species, which is endangered in China. Sequence analysis of 16s rRNA and control region (CR) fragments from mitochondrial DNA was conducted to obtain information on genetic diversity and population structure. Individuals from 12 .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038503
- DOI:
- 10.4238/gmr.15038503
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma
Authors: Z.Z. Cai, L.B. Xu, J.L. Cai, J.S. Wang, B. Zhou and H. Hu
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pancreatic tissue samples (P = 0.007.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.31
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.31
Identifying differences in protein expression levels by spectral counting and feature selection
Authors: P.C. Carvalho, J. Hewel, V.C. Barbosa and J.R. Yates III
Spectral counting is a strategy to quantify relative protein concentrations in pre-digested protein mixtures analyzed by liquid chromatography online with tandem mass spectrometry. In the present study, we used combinations of normalization and statistical (feature selection) methods on spectral counting data to verify whether.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr426
- DOI:
- 10.4238/vol7-2gmr426
Identification and abundance of miRNA in chicken hypothalamus tissue determined by Solexa sequencing
Authors: G.R. Sun, M. Li, G.X. Li, Y.D. Tian, R.L. Han and X.T. Kang
We used Solexa sequencing technology to identify and determine the abundance of miRNAs and compared the characteristics and expression patterns of miRNA of 1-day-old and 36-week-old chicken hypothalamuses. We obtained 17,825,753 and 10,928,745 high-quality reads from 36-week-old and 1-day-old chickens, respectively. Three hund.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.2.2
- DOI:
- 10.4238/2012.October.2.2
Rifampicin resistance among multi-resistant MRSA clinical isolates from Chennai, India, and their molecular characterization
Authors: K. Murugan, K. Kavitha and S. Al-Sohaibani
High-level methicillin-resistant Staphylococcus aureus (MRSA) isolates show rapid evolution of rifampicin resistance, forcing reliance upon expensive and often inferior antibiotics to manage these infections. Accordingly, this study was conducted to: 1) evaluate the level of multidrug resistance among hospital-associated MRSA isolates from Chennai, India;.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.1
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.1
Mitotic behavior in root tips of Brachiaria genotypes with meiotic chromosome elimination during microsporogenesis
Authors: M.F. Felismino, N. Silva, M.S. Pagliarini and C.B. Valle
Three accessions of Brachiaria brizantha, three of B. humidicola, and two interspecific hybrids between B. ruziziensis and B. brizantha were analyzed with regard to their mitotic behavior in root tips. All these genotypes revealed chromosome elimination or lack of chromosome affinity in previous analyses of microsporogenesis. .. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr437
- DOI:
- 10.4238/vol7-2gmr437
Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits
Authors: Z.J. Wang, R.Z. An, J.Y. Zhao, Q. Zhang, J. Yang, J.B. Wang, G.Y. Wen, X.H. Yuan, X.W. Qi, S.J. Li and X.C. Ye
After injury, inflammation, or degeneration, articular cartilage has limited self-repair ability. We aimed to explore the feasibility of repair of articular cartilage defects with tissue-engineered cartilage constructed by acellular cartilage matrices (ACMs) seeded with adipose-derived stem cells (ADSCs). The ADSCs were isolat.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.18.2
- DOI:
- http://dx.doi.org/10.4238/2014.June.18.2
Snail-induced epithelial-mesenchymal transition in gastric carcinoma cells and generation of cancer stem cell characteristics
Authors: Y.J. Yang, Z.B. Li, G.R. Zhang, L.J. Wu, J.Y. Yu, L.J. Hu, Y.L. Zhou, H.D. Wang and D. Liang
Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer ste.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038510
- DOI:
- 10.4238/gmr.15038510
Cytogenetic analysis in the spermatogenesis of Triatoma melanosoma (Reduviidae; Heteroptera)
Authors: V.B. Bardella, M.T.V. Azeredo-Oliveira and E. Tartarotti
Triatomines are of great concern in public health because they are vectors of Chagas’ disease. This study presents an analysis of the species Triatoma melanosoma. The cytogenetic characteristics of triatomines include holocentric chromosomes, post-reductional meiosis in the sex chromosomes and nucleolar fragmentation in .. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr411
- DOI:
- 10.4238/vol7-2gmr411