Gene-gene interaction between VANGL1, FZD3, and FZD6 correlated with neural tube defects in Han population of Northern China
Authors: R.P. Zhang, Y.L. Fang, B. Wu, M.N. Chemban, N. Laakhey, C.Q. Cai and O.Y. Shi
We evaluated the influence of gene-gene interactions between VANGL1, FZD3, and FZD6 on the risk of neural tube defects (NTDs) in Han population in the north of China. Two single nucleotide polymorphisms (SNPs) (rs4839469 and rs34059106) within VANGL1, two SNPs (rs2241802 and rs28639533) within FZD3, and three SNPs (rs827528, rs3808553, and rs12549394) wit.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039010
- DOI:
- 10.4238/gmr.15039010
Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis
Authors: S. Zhao, X.M. Du, S.S. Ma and L.M. Wang
Numerous studies have evaluated the association between Glu504Lys polymorphism in the aldehyde dehydrogenase 2 (ALDH2) gene and colorectal cancer (CRC) risk. However, the specific association remains controversial. To assess the relationship between the ALDH2 Glu504Lys polymorphism and CRC, we conducted a comprehensive meta-analysis of five case-control s.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037872
- DOI:
- 10.4238/gmr.15037872
Characterization of novel expressed sequence tag-simple sequence repeat markers and analysis of genetic diversity in four geographic populations of Thais luteostoma
Authors: W. Li, H.F. Jiao, Z.H. Lin, Y.B. Bao
In this study, the genetic diversity in four geographic populations (Yushan Island, Zhoushan, Wenzhou, and Xiamen) of Thais luteostoma was analyzed using 21 microsatellite loci. The results of this study showed that the alleles obtained from different populations ranged from 2 to 8. The average number of alleles and effective .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048702
- DOI:
- 10.4238/gmr15048702
Upregulation of ICAM-1 and IL-1�² protein expression promotes lung injury in chronic obstructive pulmonary disease
Authors: Y.X. Wang, M.L. Ji, C.Y. Jiang and Z.B. Qian
Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037971
- DOI:
- 10.4238/gmr.15037971
Gynophore miRNA analysis at different developmental stages in Arachis duranensis
Authors: Y. Shen, Y.H. Liu, X.J. Zhang, Q. Sha and Z.D. Chen
Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological p.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048691
- DOI:
- 10.4238/gmr15048691
Isolation and characterization of polymorphic microsatellite loci from aerial yam (Dioscorea bulbifera L.)
Authors: Q.Q. Yan, Y. Li, X.Q. Sun, J.L. Guo, Y.Y. Hang and M.M. Li
Dioscorea bulbifera L. is widely distributed in pantropical regions along the equator. The taxonomic treatment of this species is ambiguous due to its extreme polymorphic morphological characters. In order to provide tools to facilitate the study of genetic diversity, population structure, patterns of gene flow, and the mating.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.3
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.3
Estimation of diversity and combining abilities in Helianthus annuus L. under water stress and normal conditions
Authors: M. Saba, F.A. Khan, H.A. Sadaqat and I.A. Rana
Sunflower cannot produce high yields under water-limiting conditions. The aim of the present study was to prevent the impediments on yield and to develop varieties with high-yield potential under water scarce conditions. For achieving this objective, it is necessary to detect parents with desirable traits that mainly depend on.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048670
- DOI:
- 10.4238/gmr15048670
Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis
Authors: J. De Azevedo Silva, S.C. Lima, C. Addobbati, R. Moura, L.A. Cavalcanti Brand�£o, J.A. Tr�©s Pancoto, E.A. Donadi, S. Crovella and P. Sandrin-Garcia
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral toler.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048008
- DOI:
- 10.4238/gmr15048008
Investigation of mutations in the SRY, SOX9, and DAX1 genes in sex reversal patients from the Sichuan region of China
Authors: L. Chen, X.P. Ding, X. Wei and L.X. Li
We investigated the molecular genetic mechanism of sex reversal by exploring the relationship between mutations in the sex-determining genes SRY, SOX9, and DAX1 with genetic sex reversal disease. Mutations in the three key genes were detected by polymerase chain reaction (PCR) and sequencing after karyotype analysis. The mutat.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.4
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.4
eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease
Authors: A. Marin-Medina, A.J.L. Brambila-Tapia, V.J. Picos-C�¡rdenas, M.P. Gallegos-Arreola and L.E. Figuera
Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been st.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047802
- DOI:
- 10.4238/gmr15047802