Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach
Authors: A.B. Gurung, M.A. Ali, A. Bhattacharjee, K.M. Al-Anazi, M.A. Farah, F.M. Al-Hemaid, F.M. Abou-Tarboush, J. Lee, S.Y. Kim and F.S.M. Al-Anazi
Glycopentalone isolated from Glycosmis pentaphylla (family Rutaceae) has cytotoxic and apoptosis inducing effects in various human cancer cell lines; however, its mode of action is notknown. Therefore, target fishing of glycopentalone using a combined approach of inverse docking and reverse pharmacophore mapping approach was used to identify potential tar.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038544
- DOI:
- 10.4238/gmr.15038544
PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis
Authors: C.-L. Xuan, W. Yan, L. Xuan and R.-H. Xu
Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conduct.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.January.14.10
- DOI:
- http://dx.doi.org/10.4238/2014.January.14.10
Chloroplast DNA analysis of Tunisian cork oak populations (Quercus suber L.): sequence variations and molecular evolution of the trnL (UAA)-trnF (GAA) region
Authors: A. Abdessamad, G. Baraket, H. Sakka, Y. Ammari, M. Ksontini and A. Salhi Hannachi
Sequences of the trnL-trnF spacer and combined trnL-trnF region in chloroplast DNA of cork oak (Quercus suber L.) were analyzed to detect polymorphisms and to elucidate molecular evolution and demographic history. The aligned sequences varied in length and nucleotide composition. The overall ratio of transition/transversion (t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048749
- DOI:
- 10.4238/gmr15048749
Molecular characterization of the species Salvinia (Salviniaceae) from the upper Paran�¡ River floodplain
Authors: S.A. Machado, A.V. Oliveira, T.M.C. Fabrin, S.M.A.P. Prioli and A.J. Prioli
The pteridophytes Salvinia minima, S. herzogii, and S. auriculata are among the most abundant aquatic macrophytes in the upper Paraná River floodplain. Since some species have highly similar morphological features, it is very difficult to identify members of this genus to the species level. An indication of this difficulty is a set of poorly differ.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038575
- DOI:
- 10.4238/gmr.15038575
Transcriptome survey of phototransduction and clock genes in marine bivalves
Authors: X.J. Sun, L.Q. Zhou, J.T. Tian, Z.H. Liu, B. Wu, Y.H. Dong, A.G. Yang and W.M. Ma
Marine animals exhibit a variety of biological rhythms, such as solar and lunar-related cycles; however, our current molecular understanding of biological rhythms in marine animals is quite limited. Identifying and understanding the expression patterns of clock genes from available transcriptomes will help elucidate biological.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048726
- DOI:
- 10.4238/gmr15048726
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
Authors: X.M. Xu, M. Ding, H. Pang and B.J. Wang
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nu.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.1
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.1
Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population
Authors: J.B. Ma, L. Chen, B. Gao and J. Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048708
- DOI:
- 10.4238/gmr15048708
Development and characterization of SSR markers from Pinus massoniana and their transferability to P. elliottii, P. caribaea and P. yunnanensis
Authors: Y.H. Feng, Z.Q. Yang2, J. Wang, Q.F. Luo, and H.G. Li
Pinus massoniana (Masson’s pine) is a widespread tree species in central and southern China and northern Vietnam; it is valued for rosin and paper production. Despite the significant economic value of Masson’s pine, little work has been done on its molecular genetics. We developed 318 SSR primers from genome sequences of P. massoniana, and we .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.2
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.2
Correlation analysis of genetic diversity and population structure of Houttuynia cordata Thunb with regard to environment
Authors: J. Zhong, F.-C. Wu, P. Qiu and L.-J. Dai
To study the levels of genetic diversity, and population structure, of Houttuynia cordata Thunb, the genetic background and relationships of populations were analyzed in terms of environmental factors. The genetic diversity and population structure of H. cordata were investigated using sequence-related amplified polymorphisms and correlation with environm.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038780
- DOI:
- 10.4238/gmr.15038780
Structural and biochemical characteristics of chitin-binding protein SeCBP66 from Spodoptera exigua (H�¼bner)
Authors: D. Zhao, B. Liu, Y.K. Zhang, W. Guo, S.Y. Li, X.J. Lu and R.J. Li
Peritrophic membrane proteins are important components of the insect peritrophic membrane. A novel cDNA gene encoding a chitin-binding protein, named secbp66, was identified by immunization screening of the cDNA library of Spodoptera exigua. The full length of secbp66 is 1806 bp, which encodes 602 amino acids. The predicted weight of the protein is 64.2 k.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038789
- DOI:
- 10.4238/gmr.15038789