Tumor necrosis factor-�± and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients
Authors: R.M. de Albuquerque Maranh�£o, F.A. Martins Esteves, S. Crovella, L. Segat5 and P.R. Eleut�©rio Souza
The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
Normal and defective mariner-like elements in Rhynchosciara species (Sciaridae, Diptera)
Authors: P. Rezende-Teixeira, C. Lauand, F. Siviero and G.M. Machado-Santelli
Mariner-like elements are widely present in diverse organisms. These elements constitute a large fraction of the eukaryotic genome; they transpose by a “cut-and-paste” mechanism with their own transposase protein. We found two groups of mobile elements in the genus Rhynchosciara. PCR using primers designed from R. .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr796
- DOI:
- 10.4238/vol9-2gmr796
Effect of rosuvastatin on high glucose-induced endoplasmic reticulum stress in human umbilical vein endothelial cells
Authors: J.Z. Xu, Y.L. Chai and Y.L. Zhang
It is well established that endothelial injury plays an essential role in atherosclerotic plaque formation. Accumulating evidence has shown that high glucose levels may detrimentally affect cultured endothelial cells through endoplasmic reticulum (ER) stress. In this study, we investigated the effect of rosuvastatin on high gl.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048935
- DOI:
- 10.4238/gmr15048935
Transferability of microsatellite markers of Capsicum annuum L. to C. frutescens L. and C. chinense Jacq.
Authors: S.I.C. Carvalho, C.F. Ragassi, I.B. Oliveira, Z.P.S. Amaral, F.J.B. Reifschneider, F.G. Faleiro and G.S.C. Buso
In order to support further genetic, diversity, and phylogeny studies of Capsicum species, the transferability of a Capsicum annuum L. simple sequence repeat (SSR) microsatellite set was analyzed for C. frutescens L. (“malagueta” and “tabasco” peppers) and C. chinense Jacq. (smell peppers, among other types). A total of 185 SSR pri.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.1
- DOI:
- 10.4238/2015.July.17.1
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Authors: A. Sanz, L. Ordov�¡s, C. Serrano, P. Zaragoza, J. Altarriba and C. Rodellar
The bovine transferrin gene (TF) is located at 125 cM on bovine chromosome 1 (BTA1); it codes for transferrin, a glycoprotein that is highly conserved in many species and that is responsible for iron transport. The TF gene has been located in several QTL regions, and some transferrin classes have been associated with fat and m.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr784
- DOI:
- 10.4238/vol9-2gmr784
Systems genetics and genome-wide association approaches for analysis of feed intake, feed efficiency, and performance in beef cattle
Authors: M.H.A. Santana, M.C. Freua, D.N. Do, R.V. Ventura, H.N. Kadarmideen and J.B.S. Ferraz
Feed intake, feed efficiency, and weight gain are important economic traits of beef cattle in feedlots. In the present study, we investigated the physiological processes underlying such traits from the point of view of systems genetics. Firstly, using data from 1334 Nellore (Bos indicus) cattle and 943,577 single nucleotide po.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048930
- DOI:
- 10.4238/gmr15048930
Expression of �²-defensins in intestines of chickens injected with vitamin D3 and lipopolysaccharide
Authors: L. Lu, S.M. Li, L. Zhang, X.Q. Liu, D.Y. Li, X.L. Zhao and Y.P. Liu
The objective of this study was to evaluate the effect of vitamin D3 (VD3) on the regulation of chicken intestinal b-defensin genes under normal and lipopolysaccharides (LPS) conditions. Four treatment groups were used, including a negative control group, VD3-injection group, LPS-injection group, and both VD3-injection and LPS-injection group. At 4, 24, a.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.12
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.12
In silico analysis of gene content in tomato genomic regions mapped to the Ty-2 resistance gene
Authors: Y.F. Liu, H.J. Wan, Y.P. Wei, R.Q. Wang, M.Y. Ruan, Q.J. Ye, Z.M. Li, G.Z. Zhou, Z.P. Yao and Y.J. Yang
Tomato yellow leaf curl virus is one of the main diseases affecting tomato production worldwide. Previous studies have shown that Ty-2 is an important resistance gene located between molecular markers C2_At2g28250 (82.3 cM) and T0302 (89.0 cM), and exhibits strong resistance to tomato yellow leaf curl virus in Asia. In this study, Ty-2 candidate genes wer.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.2
- DOI:
- 10.4238/2015.July.17.2
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Optimizing the efficiency of the touchdown technique for detecting inter-simple sequence repeat markers in corn (Zea mays)
Authors: E.C. Oliveira, A.T. Amaral J�ºnior, L.S.A. Gon�§alves, G.F. Pena, S.P. Freitas J�ºnior, R.M. Ribeiro and M.G. Pereira
We evaluated the efficiency of the touchdown method to determine the ideal PCR conditions for distinct inter-simple sequence repeat primers for processing DNA from common corn, popcorn, sweet corn, and a Tripsacum-maize hybrid. Genomic DNA was extracted from eight accessions of corn: two of the dent type, one Tripsacum-maize h.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr767
- DOI:
- 10.4238/vol9-2gmr767