Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer
Authors: Z. Cheng, L.L. Dai, Y.N. Song, Y. Kang, J.M. Si, J. Xia and Y.F. Liu
Iron metabolism plays an important role in the pathogenesis of lung cancer. This study aimed to investigate the effect of gene silencing of iron regulatory protein-2 (IRP2) on mRNA and protein expression of transferrin (Tf), transferrin receptor (TfR), and ferritin (Fn) in A549 lung cancer cells. A549 cells were cultured and d.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.5
- DOI:
- 10.4238/2014.July.25.5
Development of microsatellite markers for Hancornia speciosa Gomes (Apocynaceae)
Authors: A.J.L. Rodrigues, A.T. Yamaguishi, L.J. Chaves, A.S.G. Coelho, J.S. Lima and M.P.C. Telles
Herein, we describe 34 microsatellite loci developed using an enrichment genomic library for the tree species Hancornia speciosa Gomes (Apocynaceae). Thirty-five individuals were genotyped using 34 primers to analyze the polymorphisms at each locus. The number of alleles per locus ranged from 4 to 20. The average number of alleles was 8.11, and the expect.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.2
- DOI:
- 10.4238/2015.July.3.2
RAPD analysis of the genetic diversity of mango (Mangifera indica) germplasm in Brazil
Authors: I.G.B. Souza, S.E.S. Valente, F.B. Britto, V.A.B. de Souza and P.S.C. Lima
We evaluated genetic variability of mango (Mangifera indica) accessions maintained in the Active Germplasm Bank of Embrapa Meio-Norte in Teresina, Piauí, Brazil, using RAPDs. Among these accessions, 35 originated from plantings in Brazil, six from the USA and one from India. Genomic DNA, extracted from leaf material usi.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.1
- DOI:
- 10.4238/2011.December.14.1
Treatment of seawater immersion-complicated open-knee joint fracture
Authors: J.G. Ai, F. Zhao, Z.M. Gao, W. Dai, L. Zhang, H.B. Chen and J.G. Zhou
The current study aimed to select suitable remedies for seawater immersion-complicated open-knee joint fracture by exploring the effects of different treatment methods. Forty adult rabbits weighing 2.20 ± 0.25 kg were divided equally into internal fracture fixation group (A), seawater-immersed group with primary interna.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.6
- DOI:
- 10.4238/2014.July.25.6
Biotechnological prospecting of foliar endophytic fungi of guaco (Mikania glomerata Spreng.) with antibacterial and antagonistic activity against phytopathogens
Authors: J.C. Polonio, T.T. Almeida, A. Garcia, G.E.G. Mariucci, J.L. Azevedo, S.A. Rhoden and J.A. Pamphile
Mikania glomerata (Spreng.), popularly known as “guaco”, is a plant from the Asteraceae family that has many therapeutic properties. The use of medicinal plants has been examined in studies on endophytic diversity and bioprospecting; endophytes inhabit the interior of plants without harming them. Microorganism-host complex interactions are rel.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.5
- DOI:
- 10.4238/2015.July.3.5
Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region
Authors: W.H. Huang, Z.X. Ma, Z.Y. Xu, Y.Z. Xiong and B. Zuo
Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and HMGA1 genes, we.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.2
- DOI:
- 10.4238/2011.December.14.2
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls
Authors: Y. Zhao, Z.L. Gui, S. Liao, F. Gao, Y.Z. Ge and R.P. Jia
Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that in.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.7
- DOI:
- 10.4238/2014.July.25.7
Genetic polymorphism in sex hormone metabolism and prostate cancer risk
Authors: E. Ersekerci, M. Sofikerim, S. Taheri, A. Demirtas and F. Halis
We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.8
- DOI:
- 10.4238/2015.July.3.8
Experimental strategies in performing value for cultivation and use experiments for the tobacco crop II: dimension of the experimental network
Authors: C.E. Pulcinelli, A.T. Bruzi, F.H.R.B. Toledo and M.A.P. Ramalho
In this study, we aimed to establish strategies for value for cultivation and use (VCU) experiments for the tobacco crop in the southern region of Brazil with respect to the number of environments used to assess tobacco lines. Trials of the Virginia (18 sites) and Burley (17 sites) varietal groups were conducted in the three s.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.8
- DOI:
- 10.4238/2014.July.25.8
Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population
Authors: T.P. Lau, A.C. Roslani, L.H. Lian, P.C. Lee, I. Hilmi, K.L. Goh and K.H. Chua
Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.9
- DOI:
- 10.4238/2014.July.25.9