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Microbial Genetics   Research Article

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

Authors: G. Tian, X. Li, H. Li, X. Wang and B. Cheng

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorp.. Read More»

Genet. Mol. Res. 14(2):
2015.May.25.1
DOI:
10.4238/2015.May.25.1
Medical Genetics   Research Article

Lack of clinical significance of the ImmuKnowTM-Cylex assay for the detection of cellular immune function in patients with renal cell carcinoma

Authors: K. Zheng, J.P. Zhang, J.M. Tan, W.Z. Wu, S.L. Yang and D.D. Ke

This study aimed to explore the clinical value of the CD4+ T cell ATP levels in patients with renal cell carcinoma through the application of the ImmuKnowTM-Cylex® assay. We recruited 104 patients with renal cancer who had undergone surgery at Fuzhou General Hospital from March 2009 to June 2012, and were subsequently treated by dendritic cell and cyt.. Read More»

Genet. Mol. Res. 14(3):
http://dx.doi.org/2015.September.28.6
DOI:
http://dx.doi.org/10.4238/2015.September.28.6
Medical Genetics   Research Article

Allele frequencies of combined DNA index system (CODIS) and non-CODIS short tandem repeat loci in Goi�?¡s, Central Brazil

Authors: R.G. Rodovalho, G.S. Santos, L.M. Cavalcanti, B.F.S.M. Moura, E.L. Rodrigues, P.R. Lima, M.A.D. Gigonzac and T.C. Vieira

In studies of human identification, obtaining a high standard of outcomes and satisfactory conclusions are directly related to the use of highly polymorphic molecular markers. In addition to the combined DNA index system (CODIS) group, it is also important to implement non-CODIS markers into the analysis, as they increase the power of discrimination. Duri.. Read More»

Genet. Mol. Res. 14(3):
2015.July.3.6
DOI:
10.4238/2015.July.3.6
Animal Genetics   Research Article

Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways

Authors: C.L. Wang, N. Li, T. Ma, P. Zhang and S.Y. You

We explored the influence of ulinastatin on apoptosis of T lymphocytes in rats with severe acute pancreatitis (SAP) and the effect of ulinastatin on mitochondrial apoptosis pathways in spleen lymphocytes. Thirty-six Wistar rats were randomly divided into three groups (N = 12): a sham operated group, a SAP group, and an ulinastatin-treated SAP group. The S.. Read More»

Genet. Mol. Res. 14(2):
2015.May.25.2
DOI:
10.4238/2015.May.25.2
Medical Genetics   Research Article

Effects of isoflurane preconditioning in the delayed phase on myocardial tumor necrosis factor alpha levels and caspase-3 protein expression in a rabbit model of ischemia-reperfusion injury

Authors: K. Ran, D.Q. Zou, Y.Y. Xiao, Y.T. Chang, K.M. Duan , Y.W. Ou and Z.J. Li

This study aimed to investigate the protective effects and the mechanisms underlying these effects of isoflurane preconditioning in the delayed phase of myocardial ischemia-reperfusion injury. We randomly divided 30 healthy male New Zealand white rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-r.. Read More»

Genet. Mol. Res. 14(3):
2015.July.3.1
DOI:
10.4238/2015.July.3.1
Human Genetics   Research Article

Decreased expression of humanized Fat-1 in porcine fetal fibroblasts following deletion of PGK-neomycin resistance

Authors: X.J. Han, H. Liang, T. Yun, Y.H. Zhao, M.L. Zhang, L.H. Zhao, R.F. Li and X.L. Li

The neomycin-resistance (neor) gene is widely used as a selectable marker in eukaryotic expression vectors; however, its expression often affects that of target genes. Cre recombinase recognizes LoxP sites, leading to site-specific recombination and deletion of DNA and RNA between two LoxP sites. In the present study, a humanized Fat-1 gene (hFat-1) was g.. Read More»

Genet. Mol. Res. 14(3):
http://dx.doi.org/2015.September.28.11
DOI:
http://dx.doi.org/10.4238/2015.September.28.11
Animal Genetics   Research Article

Development of polymorphic expressed sequence tag-single sequence repeat markers in the common Chinese cuttlefish, Sepiella maindroni

Authors: R.H. Li, S.K. Lu, C.L. Zhang, W.W. Song, C.K. Mu and C.L. Wang

The common Chinese cuttlefish (Sepiella maindroni) is one of the popular edible cephalopod consumed across Asia. To facilitate the population genetic investigation of this species, we developed fourteen polymorphic microsatellite makers from expressed sequence tags of S. maindroni. The number of alleles at ea.. Read More»

Genet. Mol. Res. 13(3):
2014.July.25.3
DOI:
10.4238/2014.July.25.3
Medical Genetics   Research Article

Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer.

Authors: H. Jiang, X.G. Fu and Y.T. Chen

We evaluated the clinical significance and explored the prognostic value of serum endothelial cell-specific molecule-1 (ESM-1) expression in colorectal cancer (CRC) in a Chinese population. Serum samples were obtained from 89 CRC patients undergoing surgical treatment and 90 healthy volunteers (control group). ESM-1 levels in serum samples from CRC patien.. Read More»

Genet. Mol. Res. 14(2):
2015.May.25.3
DOI:
10.4238/2015.May.25.3
Medical Genetics   Research Article

Molecular identification of Amazonian stingless bees using polymerase chain reaction single-strand conformation polymorphism

Authors: M.T. Souza and G.A. Carvalho-Zilse

In countries containing a mega diversity of wildlife, such as Brazil, identifying and characterizing biological diversity is a continuous process for the scientific community, even in face of technological and scientific advances. This activity demands initiatives for the taxonomic identification of highly diverse groups, such.. Read More»

Genet. Mol. Res. 13(3):
2014.July.25.4
DOI:
10.4238/2014.July.25.4
Plant Genetics   Research Article

Genetic diversity of worldwide Jerusalem artichoke (Helianthus tuberosus) germplasm as revealed by RAPD markers

Authors: P.P. Wangsomnuk, S. Khampa, P. Wangsomnuk, S. Jogloy, T. Mornkham, B. Ruttawat, A. Patanothai and Y.B. Fu

Jerusalem artichoke (Helianthus tuberosus) is a wild relative of the cultivated sunflower (H. annuus); it is an old tuber crop that has recently received renewed interest. We used RAPD markers to characterize 147 Jerusalem artichoke accessions from nine countries. Thirty RAPD primers were screened; 13 of them detected 357 repr.. Read More»

Genet. Mol. Res. 10(4):
2011.December.12.4
DOI:
10.4238/2011.December.12.4