Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia
Authors: X.L. Su, H.R. Dong, M.R. Yan, H.W. Cui, L. Yang and F.Q. Han
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cho.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.2
- DOI:
- 10.4238/2011.December.12.2
Development and characterization of 32 microsatellite loci in the giant grouper Epinephelus lanceolatus (Serranidae)
Authors: S. Yang, L. Wang, Y. Zhang, X.C. Liu, H.R. Lin and Z.N. Meng
An economically important marine fish species, the giant grouper Epinephelus lanceolatus (Serranidae) is widely cultured in Taiwan and costal areas of China. We isolated and characterized 32 polymorphic microsatellite loci from a CA-enriched genomic library of giant grouper. The number of alleles per locus ranged from 3 to 7, .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.12.3
- DOI:
- 10.4238/2011.December.12.3
Function Clustering Self-Organization Maps (FCSOMs) for mining differentially expressed genes in Drosophila and its correlation with the growth medium
Authors: L.L. Liu, M.J. Liu and M. Ma
The central task of this study was to mine the gene-to-medium relationship. Adequate knowledge of this relationship could potentially improve the accuracy of differentially expressed gene mining. One of the approaches to differentially expressed gene mining uses conventional clustering algorithms to identify the gene-to-medium relationship. Compared to co.. Read More»
- Genet. Mol. Res. 14(3):
- DOI http://dx.doi.org/2015.September.28.18
- DOI:
- DOI http://dx.doi.org/10.4238/2015.September.28.18
Worldwide diversity of the Y-chromosome tetra-local microsatellite DYS464
Authors: F.S.G. Kehdy and S.D.J. Pena
Of all DNA markers on the human Y-chromosome, the tetra-local Y-linked microsatellite DYS464 is the most polymorphic. We genotyped DYS464 in 677 male samples collected worldwide, maintained in the HGDP-CEPH Human Genome Diversity Cell Line Panel. Fourteen different alleles were found, with allele lengths varying from 9 to 23 r.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr968
- DOI:
- 10.4238/vol9-3gmr968
Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis.
Authors: C. Wang, D.Z. Hu and J.Z. Liu
To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.19
- DOI:
- 10.4238/2015.May.22.19
Characterization and expression of the calpastatin gene in Cyprinus carpio
Authors: W.X. Chen and Y. Ma
Calpastatin, an important protein used to regulate meat quality traits in animals, is encoded by the CAST gene. The aim of the present study was to clone the cDNA sequence of the CAST gene and detect the expression of CAST in the tissues of Cyprinus carpio. The cDNA of the C. carpio CAST gene, amplified using rapid amplification of cDNA ends PCR, is 2834 .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.16
- DOI:
- 10.4238/2015.July.3.16
No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population
Authors: L.P. Sun*, X.L. Ma*, H.X. Liu, Y.S. Wang and X.F. Li
Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr914
- DOI:
- 10.4238/vol9-3gmr914
Cytogenetic damage in the buccal epithelium of Brazilian aviators occupationally exposed to agrochemicals
Authors: L.B. Minasi, E.O.A. Costa, D.M. Silva, C.O.A. Melo, J.G. de Almeida, T.C. Vieira, R.L. Silva J�ºnior, C.L.Ribeiro, C.C. da Silva and A.D. da Cruz
The frequency of micronuclei in both buccal cells and peripheral blood lymphocytes is extensively used as a biomarker of chromosomal damage and genome stability in human populations. We examined whether prolonged exposure to complex mixtures of Short Communication pesticides leads to an increase in cytogenetic damage. The expo.. Read More»
- Genet. Mol. Res. 10(4):
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies
Authors: Y. Zhao, J. Liang, J.G. Qi, N. Yang, G. Wu, Y.L. Lin, J.Y. Cao, Q. Wang and Q.C. Wang
Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.18
- DOI:
- 10.4238/2015.July.3.18
Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4
Authors: W. Zhou, H. Lv, M.X. Li, H. Su, L.G. Huang, J. Li and W.M. Yuan
We established a necrotizing enterocolitis (NEC) rat model and explored the role of bifidobacteria in the intestines of the rats and its regulation on intestinal Toll-like receptors (TLRs). Seventy-five newborn Sprague-Dawley rats were randomly divided into 5 groups (15 rats/group): group A, artificial feeding group (formula-fed); group B, NEC model (LPS .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.28.2
- DOI:
- http://dx.doi.org/10.4238/2015.September.28.2