Association between RsaI polymorphism in estrogen receptor �² gene and male infertility
Authors: B.M. Bordin and K.K.V.O. Moura
The estrogen receptor β (ERβ) gene plays an important role in the regulation of fertility in both males and females. The RsaI polymorphism in ERβ is associated with male infertility in Caucasian patients. The aim of this study was to investigate the frequency of this polymorphism in the etiology of idiopathic male infertility and its correl.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.21.7
- DOI:
- http://dx.doi.org/10.4238/2015.September.21.7
Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model
Authors: Chaves GM, Bates S, MacCallum DM and Odds FC
Resistance of Candida albicans to reactive oxygen species is thought to enhance its virulence in mammalian hosts. Genes such as SOD1, which encodes the anti-oxidant, superoxide dismutase, are known virulence factors. We disrupted the gene GRX2, which encodes a putative glutathione reductase (glutaredoxin) in C. albicans, and w.. Read More»
- Genet. Mol. Res. 6(4):
Influence of interleukin-1�² and interleukin-6 gene polymorphisms on the development of acute pancreatitis
Authors: D.Z. Chi, J. Chen and D.P. Huang
We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1b and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1Ã?² +3954 C/T (rs1143634) and IL-1Ã?² -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The geno.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.5
- DOI:
- 10.4238/2015.February.3.5
Effects of VEGF suppression by small hairpin RNA interference combined with radiotherapy on the growth of cervical cancer
Authors: L. Qi, L.N. Xing, X. Wei and S.G. Song
This study aimed to investigate the inhibition of vascular endothelial growth factor (VEGF) by small hairpin RNA (shRNA) interference combined with radiotherapy on the growth of cervical cancer SiHa cell xenografts in nude mice. The effective pVEGF-shRNA plasmid was screened by reverse transcription-polymerase chain reaction (.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.7.2
- DOI:
- 10.4238/2014.July.7.2
Association between ERCC1 and ERCC2 polymorphisms and breast cancer risk in a Chinese population
Authors: R. Zhao and M.F. Ying
We conducted a case-control study to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms in the development of breast cancer. Between March 2012 and March 2014, a total of 242 newly diagnosed breast cancer patients with histopathologically confirmed primary breast cancer and 242 healthy controls were recruited. Genotyping of ERCC1.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017263
- DOI:
- 10.4238/gmr.15017263
High-throughput, low-cost, and event-specific polymerase chain reaction detection of herbicide tolerance in genetically modified soybean A2704-12
Authors: H. Ma, H. Li, J. Li, X.F. Wang, P.C. Wei, L. Li and J.B. Yang
The aim of this study was to develop an event-specific qualitative and real-time quantitative polymerase chain reaction (PCR) method for detection of herbicide-tolerance genetically modified (GM) soybean A2704-12. The event-specific PCR primers were designed, based on the 5'-flanking integration sequence in the soybean genome,.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.14
- DOI:
- 10.4238/2014.January.28.14
Isolation and identification of the immune-relevant ribosomal protein L10 (RPL10/QM-like gene) from the large yellow croaker Pseudosciaena crocea (Pisces: Sciaenidae)
Authors: X. Chen Y.Q. Su J. Wang M. Liu S.F. Niu S.P. Zhong F. Qiu
In order to investigate the immune role of ribosomal protein L10 (RPL10/QM-like gene) in marine fish, we challenged the large yellow croaker Pseudosciaena (= Larimichthys) crocea, the most important marine fish culture species in China, by injection with a mixture of the bacteria Vibrio harveyi and V. parahaemolyticus (3:1 in volume). Microarray analysis .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.7
- DOI:
- 10.4238/2012.October.15.7
Pedigree analyses in the Breeding Program for Nellore Cattle
Authors: Vozzi PA, Marcondes CR, Bezerra LAF and Lobo RB
Parameters based on the probability of gene origin were used to describe genetic variability in three reproductive groups from the Breeding Program for Nellore Cattle (PMGRN). The three reproductive populations (cows in reproductive age, bulls from artificial insemination centers and young bulls in progeny test) generated medi.. Read More»
- Genet. Mol. Res. 6(4):
Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis
Authors: F. Fang, J. Wang, J. Pan, G.H. Su, L.X. Xu and G. Li
The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC).. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.1
- DOI:
- 10.4238/2015.February.6.1
Major congenital anomalies: a five-year retrospective regional study in Turkey
Authors: A.G. Tomatir H. Demirhan H.��. Sorkun A. K�¶ksal F. ��zerdem N. ��ilengir
We examined the distribution and demographic characteristics of congenital anomalies in a Turkish province for five years. The records of 63,159 live births between 2000 and 2004 were examined retrospectively. Major congenital anomalies were classified according to year, organ system, gender, family relationship, maternal age,.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr506
- DOI:
- 10.4238/vol8-1gmr506