Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury
Authors: X.E. Meng, Y. Zhang, N. Li, D.F. Fan, C. Yang, H. Li, D.Z. Guo and S.Y. Pan
We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury g.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016933
- DOI:
- 10.4238/gmr.15016933
TLR4/NF-?ºB signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells
Authors: Y. Feng, Z.R. Cai, Y. Tang, G. Hu, J. Lu3, D. He and S. Wang
This study aimed to investigate the function and signaling pathway of Toll-like receptor 4 (TLR4) in oxidized low-density lipoprotein (oxLDL)-induced up-regulated expressions of oxidized LDL receptor 1 (LOX-1), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein en.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.28.13
- DOI:
- 10.4238/2014.January.28.13
Meta-analysis of constitutive QTLs for disease resistance in maize and its synteny conservation in the rice genome
Authors: L. Zhao, H.J. Liu, C.X. Zhang, Q.Y. Wang and X.H. Li
We collected data regarding 340 disease resistance quantitative trait loci (QTLs) from the maize genomic database (MaizeGDB). We constructed an integrated linkage map and analyzed this map by using the BioMercator 2.1 software with IBM2 2008 Neighbors genetic linkage map as a reference. We used a meta-analysis method to identify five â??consensusâ? sy.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.3
- DOI:
- 10.4238/2015.February.3.3
Co-evolution of genomic islands and their bacterial hosts revealed through phylogenetic analyses of 17 groups of homologous genomic islands
Authors: F.-B. Guo W. Wei X.L. Wang H. Lin H. Ding J. Huang N. Rao
Horizontal gene transfer is an important mechanism for the evolution of microbial genomes, and many horizontal gene transfer events are facilitated by genomic islands (GIs). Until now, few reports have provided evidence for the co-evolution of horizontally transferred genes and their hosts. We obtained 17 groups of homologous GIs, all of which appear in 8.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.5
- DOI:
- 10.4238/2012.October.15.5
Identification of a Panax ginseng fruit fingerprint by HPLC-ESI-MS
Authors: H.F. Zhao1, F.F. Xu2, Y.T. Guo1 and H. Mi1
Over many years, parts of Panax ginseng (root and rhizome) have been identified and applied for medical purposes as traditional Chinese herbal medicine. Recently, research has indicated that ginseng fruit also contains similar compounds and is as rich as the other parts of the ginseng. This discovery may dramatically improve the efficient of outputs deriv.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017235
- DOI:
- 10.4238/gmr.15017235
Development of a novel set of microsatellite markers for Lippia alba (Verbenaceae)
Authors: D.S. Rocha, C.P. Santos, M.M. Bajay, J.B. Campos, A.F. Blank,J.B. Pinheiro and M.I. Zucchi
Microsatellite primers were developed and optimized for Lippia alba to characterize the L. alba germplasm bank of Universidade de S?£o Paulo. A genomic library enabled the design of 9 microsatellite primers. Six of the 9 primers yielded polymorphic products, which defined 2 groups in the bank. The data provide support to characterize germplasm banks, genet.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.3.4
- DOI:
- 10.4238/2015.February.3.4
shRNA inhibits the expression of chicken telomerase reverse transcriptase in MDCC-MSB1 cells
Authors: N. Jiang, X.B. Zheng, Z.Y. Zhao, Z.G. Qin and T.J. Liu
Here, we investigated the effects of blocking chicken telomerase reverse transcriptase (chTERT) in MDCC-MSB1 cells, using small-hairpin RNAs (shRNAs) to interfere with gene expression. shRNAs specific to chTERT mRNA were designed, cloned into DNA plasmid vectors, and transfected into MDCC-MSB1 cells. The transfected chTERT RNAs were expressed by the RNA p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016979
- DOI:
- 10.4238/gmr.15016979
Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins
Authors: Z.L. Zhao C.F. Wang Q.L. Li Z.H. Ju J.M. Huang J.B. Li J.F. Zhong J.B. Zhang
The mannan-binding lectin gene (MBL) participates as an opsonin in the innate immune system of mammals, and single nucleotide polymorphisms (SNPs) in MBL cause various immune dysfunctions. In this study, we detected SNPs in MBL2 at exon 1 using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chi.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.6
- DOI:
- 10.4238/2012.October.15.6
Gene expression of antioxidant enzymes and coffee seed quality during pre- and post-physiological maturity
Authors: F.C. Santos, F. Caixeta, A.C.S. Clemente, E.V. Pinho and S.D.V.F. Rosa
Seeds collected at different maturation stages vary in physiological quality and patterns of protective antioxidant systems against deterioration. In this study we investigated the expression of genes that codify catalase (CAT), dismutase superoxide (SOD), and polyphenol oxidase (PPO) during the pre- and post-physiological maturation phases in whole seeds.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014
Identification of PML/RAR?± fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization
Authors: A. Choughule S. Polampalli P. Amre S. Shinde S. Banavali K. Prabhash R. Nair P.G. Subramanian S. Gujral P.M. Parikh
Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17)(q22;q11-21), resulting in the fusion of the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARα) genes. Using conventional cytogenetic methods, these translocations are normally detected in about 70-90% of patients.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr488
- DOI:
- 10.4238/vol8-1gmr488