Xiayuxue decoction reduces renal injury by promoting macrophage apoptosis in hepatic cirrhotic rats
Authors: C. Liu, J. Cai, Z. Cheng, X. Dai, L. Tao, J. Zhang and D. Xue
Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.15
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.15
Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases
Authors: Z.-Y. Li, F. Shan, L.-H. Zhang, Z.-D. Bu, A.-W. Wu, X.-J. Wu, X.-L. Zong, S.-X. Li, X. Ji and J.-F. Ji
Gastric cancer is the fourth most common cancer worldwide and the leading cause of tumor-related death in China. Gastric cancer is a heterogeneous disease and therefore requires different treatments based on the subtype. We describe a patient who had gastric cancer with liver metastases. Biopsy and tumor analysis using the HercepTest revealed a human epid.. Read More»
- Genet. Mol. Res. 13(4):
- 2014
- DOI:
- 10.4238/2014
Cohn process influences the functional anticoagulant activity of human protein C
Authors: Z.K. Wang, X. Du1, Y.M. Wang, C.Q. Li, F.Z. Lin, H.J. Cao, S.L. Ye, J.J. Hu and J. Yuan
Cohn fraction IV (CFIV) is a byproduct of a plasma fractionation process known as the Cohn process. It is an inexpensive source of protein C, retaining about 90% of protein C (PC) in human plasma. We investigated whether PC is affected during the Cohn process and evaluated correlations among coagulant activity, amidolytic activity and PC antigen during the C.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.10
- DOI:
- 10.4238/2015.February.2.10
Sting_rdb: a relational database of structural parameters for protein analysis with support for data warehousing and data mining
Authors: Oliveira SRM, Almeida GV, Souza KRR, Rodrigues DN, Kuser-Falcao PR, Yamagishi MEB, Santos EH, Vieira FD, Jardine JG and Neshich G
An effective strategy for managing protein databases is to provide mechanisms to transform raw data into consistent, accurate and reliable information. Such mechanisms will greatly reduce operational inefficiencies and improve one’s ability to better handle scientific objectives and interpret the research results. To ach.. Read More»
- Genet. Mol. Res. 6(4):
Expression divergence of FRUITFULL homeologs enhanced pod shatter resistance in Brassica napus
Authors: P.F. Peng, Y.C. Li, D.S. Mei, J. Colasanti, L. Fu, J. Liu, Y.F. Chen and Q. Hu
To improve pod shatter resistance in the important oilseed crop Brassica napus, the phenotypic diversity of B. napus was tested using 80 B. napus varieties for pod shatter resistance by a random impact test. Among these varieties, R1-1 was identified as resistant, while R2, 8908B was susceptible to shatter. To understand the molecular basis for this pheno.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.11
- DOI:
- 10.4238/2015.February.2.11
Potential of maize single-cross hybrids for extraction of inbred lines using the mean components and mixed models with microsatellite marker information
Authors: M. Balestre, R.G. Von Pinho, J.C. Souza and J.C. Machado
The present study examined the importance of mean (m+a’ and d) components in the performance of single-cross hybrids for the formation of new populations and determined the contribution of the mixed model (best linear unbiased predictor of random effects, BLUP) method associated with molecular markers for the choice of crosses to obtain interpopulat.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr491
- DOI:
- 10.4238/vol7-4gmr491
Construction of polycythemia vera protein interaction network and prediction of related biological functions
Authors: L.-J. Liu1, X.-J. Cao2, C. Zhou1, Y. Sun3, Q.-L. Lv3, F.-B. Feng1, Y.-Y. Zhang4 and C.-G. Sun1
Here, polycythemia vera (PV)-related genes were screened by the Online Mendelian Inheritance in Man (OMIM), and literature pertaining to the identified genes was extracted and a protein-protein interaction network was constructed using various Cytoscape plugins. Various molecular complexes were detected using the Clustervize plugin and a gene ontology-enr.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017169
- DOI:
- 10.4238/gmr.15017169
Effects of intermittent hypobaric hypoxia preconditioning on the expression of neuroglobin and Bcl-2 in the rat hippocampal CA1 area following ischemia-reperfusion
Authors: Q. Wu, K.X. Yu, Q.S. Ma and Y.N. Liu
This study was aimed at understanding the effect of intermittent hypobaric hypoxia preconditioning (IHHP) on neuroglobin (NGB) and Bcl-2 expression in the hippocampal CA1 region of rats following global cerebral ischemia-reperfusion. Wistar rats were randomly divided into sham, IHHP control, global cerebral ischemia-reperfusion (IR group), and IHHP+IR gro.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.18
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.18
Phylogenetic analysis of widely cultivated Ganoderma in China based on the mitochondrial V4-V6 region of SSU rDNA
Authors: X.W. Zhou, K.Q. Su and Y.M. Zhang
Ganoderma mushroom is one of the most prescribed traditional medicines and has been used for centuries, particularly in China, Japan, Korea, and other Asian countries. In this study, different strains of Ganoderma spp and the genetic relationships of the closely related strains were identified and investigated based on the V4-V6 region of mitochondrial sm.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.2.12
- DOI:
- 10.4238/2015.February.2.12
Proteomic changes in maize as a response to heavy metal (lead) stress revealed by iTRAQ quantitative proteomics
Authors: G.K. Li1,3*, J. Gao4*, H. Peng1,2, Y.O. Shen1, H.P. Ding1, Z.M. Zhang1, G.T. Pan1 and H.J. Lin1
Lead (Pb), a heavy metal, has become a crucial pollutant in soil and water, causing not only permanent and irreversible health problems, but also substantial reduction in crop yields. In this study, we conducted proteome analysis of the roots of the non-hyperaccumulator inbred maize line 9782 at four developmental stages (0, 12, 24, and 48 h) under Pb pol.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017254
- DOI:
- 10.4238/gmr.15017254