Increased ROS generation and SOD activity in heteroplasmic tissues of transmitochondrial mice with A3243G mitochondrial DNA mutation
Authors: J. Li1, K. Zhou2, X. Meng1, Q. Wu1, S. Li1, Y. Liu2 and J. Wang1
The mitochondrial A3243G tRNALeu(UUR) mutation associated with a variety of mitochondrial disorders results in a severe respiratory deficiency, an increase in reactive oxygen species (ROS) production and activities of anti-oxidative enzyme in vitro. However, the phenotypic implications of this mutation have not been described in vivo. Here, mitochondria c.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr480
- DOI:
- 10.4238/vol7-4gmr480
Mutational characterization of the P3H1/CRTAP/CypB complex in recessive osteogenesis imperfecta
Authors: C. Barbirato, M. Trancozo, M.G. Almeida, L.S. Almeida, T.O. Santos, J.C.G. Duarte,M.R.G.O. Rebou�§as, V. Sipolatti, V.R.R. Nunes, F. Paula
Osteogenesis imperfecta (OI) is a genetic disease characterized by bone deformities and fractures. Most cases are caused by autosomal dominant mutations in the type I collagen genes COL1A1 and COL1A2; however, an increasing number of recessive mutations in other genes have been reported. The LEPRE1, CRTAP, and PPIB genes encod.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.36
- DOI:
- 10.4238/2015.December.1.36
Molecular cloning and characterization of a novel chicken gene named grni
Authors: Y. Hua, D.Y. Hui, Z.H. Rong and T. Cheng
The full-length cDNA sequence of a novel expressed sequence tag (GenBank accession No. HQ184338) that was differentially expressed during Newcastle disease virus (NDV) infection in chickens was cloned from the chicken spleen by a rapid amplification of cDNA ends assay. This gene was further analyzed using bioinformatic methods.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.6
- DOI:
- 10.4238/2014.January.21.6
Regulation of human alpha-globin gene expression and alpha-thalassemia
Authors: D.M. Ribeiro and M.F. Sonati
Hemoglobin and globin genes are important models for studying protein and gene structure, function and regulation. We reviewed the main aspects of regulation of human α-globin synthesis, encoded by two adjacent genes (α2 and α1) clustered on chromosome 16. Their expression is controlled mainly by a regulatory element located 40 kb upstre.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr472
- DOI:
- 10.4238/vol7-4gmr472
Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis
Authors: B.F. Chen,R. Wang,Y.J. Chen,Y. Zhu, L. Ding,Y.F. Wen
Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.37
- DOI:
- 10.4238/2015.December.1.37
Transcriptional profiles of emasculated flowers of black locust (Robinia pseudoacacia) determined using the cDNA-AFLP technique
Authors: J.X. Wang, P. Sun, C.Q. Yuan, L. Dai, Y. Zhang, B. Wu, C. Long, Y.H. Sun, Y. Li
Black locust (Robinia pseudoacacia) is a tree in the subfamily Faboideae, native to North America, that has been naturalized and widely planted in temperate Europe and Asia. Black locust has important ecological and economic value, but its quality needs improvement. Hybridization programs are important for black locust breedin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.34
- DOI:
- 10.4238/2015.December.1.34
Relationship between the HLA-G 14bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis
Authors: S.K. Kim, K.H. Jeong,I.J. Kang, J.H. Chung, M.K. Shin, M.H. Lee
Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.35
- DOI:
- 10.4238/2015.December.1.35
Biological characteristics and mating type distribution of Phytophthora capsici from China
Authors: Y. Du, Z.-H. Gong, G.-Z. Liu, G.-X. Chai and C. Li
Phytophthora capsici from seven provinces of China were investigated for their mating type, hyphal growth, zoospore production, and virulence. All of the morphological characteristics and the results of polymerase chain reaction confirmed that these isolates were indeed Phytophthora capsici. The test of mating type showed that.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.7
- DOI:
- 10.4238/2014.January.21.7
A molecular study on the evolution of a subtype B variant frequently found in Brazil
Authors: M.E. Pinto1, C.G. Schrago1, A.B. Miranda2 and C.A.M. Russo1
In spite of the remarkable diversity of HIV-1 env genes, several amino acids are extremely conserved, probably due to functional constraints. One example is the proline found at the second position of the GPGR motif. Several viruses, however, bear substitutions at this site, for instance, GWGR subtype B variant. GWGR viruses are described in Brazil since .. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr383
- DOI:
- 10.4238/vol7-4gmr383
Role of interleukin-10 gene polymorphisms in the development of coronary artery disease in Chinese population
Authors: H.M. Xu,Y.R. Liu
The aim of this study was to investigate the association between three common SNPs (-1082A/G, -819T/C, and -592A/C) in the interleukin 10 (IL-10) gene, and the development of coronary artery disease. Between January 2013 and December 2014, 272 patients with coronary artery disease and control subjects (each) were recruited for.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.38
- DOI:
- 10.4238/2015.December.1.38