Effect of specific silencing of EMMPRIN on the growth and cell cycle distribution of MCF-7 breast cancer cells
Authors: X.Q. Yang, J. Yang, R. Wang, S. Zhang, Q.W. Tan, Q. Lv, W.T. Meng, X.M. Mo, H.J. Li
The extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the immunoglobulin family and shows increased expression in tumor cells. We examined the effect of RNAi-mediated EMMPRIN gene silencing induced by lentiviral on the growth and cycle distribution of MCF-7 breast cancer cells. Lentiviral expressin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.24
- DOI:
- 10.4238/2015.December.1.24
Distribution of constitutive heterochromatin in Pachycoris torridus (Hemiptera, Scutelleridae) with different chromatic patterns
Authors: T.S. Souza-Firmino, K.C.C. Alevi, L.L.V. Pereira, E.R.S. Souza, F.C.S. J�ºnior,C.A. Banho, G.O. Carmo, M.M. Itoyama
The stink bug Pachycoris torridus is a pest of great agricultural importance due to its records on culture of physic nut (Jatropha curcas), which is the raw material for biodiesel production. An interesting feature of this insect is its high phenotypic variability, a characteristic that resulted in it being classified as a new.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.26
- DOI:
- 10.4238/2015.December.1.26
Homologous recombination between HERVs causes duplications in the AZFa region of men accidentally exposed to cesium-137 in Goi�¢nia
Authors: J.T. Arruda1, D.M. Silva1,2, C.C. Silva1,2, K.K.V.O. Moura1 and A.D. da Cruz1,2
In September 1987, in Goiânia, Brazil, one of the most serious radiological accidents occurred at a radiation therapy unit involving a source of cesium-137. The current study examined the occurrence of possible germline mutations at the AZF region of the exposed men and in their male offspring. Genomic DNA samples of 16 individuals were analyzed for.. Read More»
- Genet. Mol. Res. 7(4):
Identification of a novel mutation of the EDA gene in X-linked hypohidrotic ectodermal dysplasia
Authors: J.J. Xue, B. Tan, Q.P. Gao,G.S. Zhu,D.S. Liang,L.Q. Wu
This study aimed to identify the disease-causing mutation in the ectodysplasin A (EDA) gene in a Chinese family affected by X-linked hypohidrotic ectodermal dysplasia (XLHED). A family clinically diagnosed with XLHED was investigated. For mutation analysis, the coding region of EDA of 2 patients and 7 unaffected members of the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.29
- DOI:
- 10.4238/2015.December.1.29
Genetic progress estimation strategy for upright common bean plants using recurrent selection
Authors: L.A. Pereira, A.F.B. Abreu, I.C. Vieira J�ºnior, L.P.M. Pires,M.A.P. Ramalho
Common bean producers in Brazil tend to grow plants as upright as possible. Because the control of this trait involves a large number of genes, recurrent selection (RS) is the best approach for successful plant improvement. Because plant architecture (PA) is evaluated using scores and usually has high heritability, RS for PA i.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019494
- DOI:
- 10.4238/gmr16019494
Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density
Authors: C.G. Gon�§alves, B.C. Almeida, C.M. Camargo-Kosugi, A.M.M. Costa, I.D.C.G. Silva, M.A. Haidar
In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.32
- DOI:
- 10.4238/2015.December.1.32
Investigation of the association between Interleukin-10 polymorphisms and risk of acute pancreatitis in a Chinese population
Authors: H.L. Jia, P.L. Sun,C.Q. Lu
We conducted a case-control study to investigate the possible association between three common single nucleotide polymorphisms in interleukin-10 (IL-10) and the development of acute pancreatitis in a Chinese population. Between January 2013 and December 2014, 255 patients with acute pancreatitis and 255 control subjects were r.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.39
- DOI:
- 10.4238/2015.December.1.39
Prevention of DNA damage and anticarcinogenic activity of Activia�® in a preclinical model
Authors: S.M.A. Limeiras, F.M. Ogo, L.A.L. Genez, C.M. Carreira,E.J.T. Oliveira, L.R. Pessatto, S.C. Neves, J.R. Pesarini, L.C. Schweich, R.A. Silva, W.B. Cantero, A.C.M.B. Antoniolli-Silva, R.J. Oliveira
Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria comb.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019492
- DOI:
- 10.4238/gmr16019492
Effect of different compounds on the induction of laccase production by Agaricus blazei
Authors: J.S. Valle, L.P.S. Vandenberghe,A.C.C. Oliveira, M.F. Tavares,G.A. Linde, N.B. Colauto, C.R. Soccol
Laccases are polyphenol oxidases produced by many fungi and have many applications in textile, food and beverage, and pulp and paper industries. Laccase production can be induced using aromatic or phenolic compounds that mostly affect the transcription of laccase-encoding genes. In this study, we analyzed laccase and biomass p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.40
- DOI:
- 10.4238/2015.December.1.40
Effect of the IkB�± mutant gene delivery to mesenchymal stem cells on rat chronic pancreatitis
Authors: T. Qin, C.J. Liu, H.W. Zhang, Y.F. Pan Q. Tang, J.K. Liu,Y.Z. Wang M.X. Hu and F. Xue
This study aimed to investigate the effect of inhibitors of the NF-kΒ alpha mutant gene (IkBaM) delivery to mensenchymal stem cells (MSCs) on rat chronic pancreatitis (CP). A total of 120 Sprague-Dawley rats were randomly divided into 6 groups of 20: Group A was injected with sterile saline solution, Group B was injected .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.21.5
- DOI:
- 10.4238/2014.January.21.5