Correlation between polymorphisms in the estrogen receptor �± gene and coronary heart disease: A meta-analysis
Authors: W. Zhou, K.H. He and M.H. Chen
The aim of this study was to conduct a systematic evaluation the correlation between polymorphisms in the estrogen receptor α gene (ESRα) and coronary heart disease susceptibility. Case-control studies until August 2015 analyzing the correlation between the ESRα PvuII T/C polymorphism and coronary heart disease were obtained from various.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037835
- DOI:
- 10.4238/gmr.15037835
Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays
Authors: Y.D. Apalasamy , F.M. Moy, S. Rampal, A. Bulgiba and Z. Mohamed
A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.4
- DOI:
- 10.4238/2014.July.4.4
Two genetic stocks of Steindachneridion melanodermatum living in sympatry in nature and genetic variability of wild parents and F1 generation
Authors: D.A. Matoso, M. da Silva, M.C.S. Cortinhas, M.M. Cestari, M.C. de Almeida, M.R. Vicari and R.F. Artoni
Steindachneridion melanodermatum is a large Brazilian catfish, highly prized for sport fishing and for its meat. Specimens of this species, both caught in nature from Iguacu River and F1 fish born in captivity, were analyzed with regard to patterns of RAPD molecular markers. Genetic similarity ranged from 0.57 to 0.95; two gro.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.25.8
- DOI:
- 10.4238/2011.October.25.8
Bone morphogenetic protein 9 facilitates osteocarcinoma cell apoptosis and inhibits in vivo tumor growth
Authors: J. Zhang, J.H. Liang and J.G. Huang
Osteosarcoma (OS) causes millions of death worldwide and, since there is no effective therapy, it is necessary to identify the molecular mechanism of OS, which can direct the development of new therapies. This study investigated the role of bone morphogenetic protein 9 (BMP9), a member of the transforming growth factor (TGF)-β family, in OS developme.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038036
- DOI:
- 10.4238/gmr.15038036
Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome
Authors: L. Wei, Y. An and J. Wang
Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038401
- DOI:
- 10.4238/gmr.15038401
Clinical study of the correlation between complement factor H polymorphism and age-related macular degeneration
Authors: H.T. Dong, J.X. Zhang, Q.M. Li and F.Z. Li
This study aimed to investigate the correlation between age-related macular degeneration (AMD) of the liver-kidney yin-deficiency type and complement factor H (CFH) polymorphism, and to determine whether the C allele of the T1277C (Y402H) variant is a risk factor for this condition. We performed a case-control investigation of 60 patients with liver-kidne.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038457
- DOI:
- 10.4238/gmr.15038457
A novel set of single-copy nuclear DNA markers for the genetic study of Salicaceae
Authors: S.H. Du, Z.S. Wang and J.G. Zhang
Species of Populus are widely distributed worldwide, playing a significant role in both ecology and economy. However, the lack of single-copy nuclear markers limits knowledge about the phylogeny and population genetics of this genus. In the present study, primer pairs of 15 single-copy nuclear markers were developed t.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.5
- DOI:
- 10.4238/2014.July.4.5
Diversity and potential application of endophytic bacteria in ginger
Authors: T. Chen, Z. Chen, G.H. Ma, B.H. Du, B. Shen, Y.Q. Ding and K. Xu
Here, 248 endophytic bacterial strains were isolated to assess the distribution and population diversity of endophytic bacteria in ginger plants. A total of 10.4 x 104 to 20.2 x 104 CFU/g fresh weight endophytic bacteria of different growth stages were isolated. Maximum bacterium numbers were obtained at the seedling stage. A .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.6
- DOI:
- 10.4238/2014.July.4.6
Cytochrome c oxidase subunit I barcoding of the green bee-eater (Merops orientalis)
Authors: I.A. Arif, H.A. Khan, M. Shobrak and J. Williams
DNA barcoding using mitochondrial cytochrome c oxidase subunit I (COI) is regarded as a standard method for species identification. Recent reports have also shown extended applications of COI gene analysis in phylogeny and molecular diversity studies. The bee-eaters are a group of near passerine birds in the family Meropidae. .. Read More»
- Genet. Mol. Res. 10(4):
Effect of pregnane X receptor polymorphisms on tacrolimus blood concentrations and the resulting adverse reactions in kidney transplantation recipients
Authors: Z.P. Wang, M. Zhao, Q.S. Qu and S.Z. Miao
We investigated the effect of pregnane X receptor (PXR) polymorphisms on tacrolimus (FK506) blood trough concentrations and the associated adverse reactions in kidney transplantation recipients (KTRs). Polymerase chain reaction (PCR)-restriction fragment length polymorphism was used to detect the genotypes of single nucleotide polymorphism loci in 336 KTR.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038464
- DOI:
- 10.4238/gmr.15038464