Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells
Authors: D.X. Li, J. Zhang, Y. Zhang, P.W. Zhao and L.M. Yang
Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-depe.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.17
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.17
Molecular cloning, expression, and regulation of the ovalbumin gene in pigeon oviduct epithelial cells
Authors: H. Zhang, L.Z. Lu, L. Chen, Z.R. Tao, F. Chen, S.L. Zhong,Y.L. Liu, Y. Tian and P.S. Yan
The full-length pigeon ovalbumin (OVA) gene cDNA was cloned and sequenced by reverse transcription-polymerase chain reaction (RT-PCR) and rapid-amplification of cDNA ends. A 386-amino acid protein was predicted for the obtained sequence, which had 67% identity with the chicken protein. Similar to chicken OVA, the pigeon OVA ge.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.2
- DOI:
- 10.4238/2014.January.10.2
Comprehensive analysis of patched domain-containing genes reveals a unique evolutionary pattern
Authors: Y. Zhong, L.J. Gu*, X.G. Sun, S.H. Yang and X.H. Zhang
Patched domain-containing genes are members of a small family originally identified in Drosophila. A common feature of transmembrane patched domain-containing proteins is their function in the transport of sterols, sterol-modified proteins, and lipids. Recently, an expansion phenomenon of patched domain-containing gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.13.11
- DOI:
- 10.4238/2014.February.13.11
Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis
Authors: L.L. Zhang, J. Gong and C.T. Liu
Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We se.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.13.10
- DOI:
- 10.4238/2014.February.13.10
Genetic bottlenecks in Turkish okra germplasm and utility of iPBS retrotransposon markers for genetic diversity assessment
Authors: M. Y�±ld�±z, M. Ko�§ak and F.S. Baloch
Lack of requisite genetic variation in Turkish okra has necessitated the use of different types of markers for estimating the genetic diversity and identifying the source of variation. Transposable elements, present abundantly in plant genomes, generate genomic diversity through their replication and are thus an excellent source of molecular markers. We h.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.20
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.20
DNA extraction from bristles and quills of Chaetomys subspinosus (Rodentia: Erethizontidae) using a novel protocol
Authors: C.G. Oliveira, R.A. Martinez, F.A. Gaiotto
DNA extraction protocols are as varied as DNA sources. When it comes to endangered species, it is especially important to pay attention to all details that ensure the completion of the study goals and effectiveness in attaining useful data for conservation. Chaetomys subspinosus (Rodentia: Erethizontidae) is a secretive arbore.. Read More»
- Genet. Mol. Res. 6(3):
Association between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma
Authors: M.L. Li, Y. Dong, Y.Z. Hao, N. Xu, F.L. Ning, S.S. Chen and J.M. Yu
We conducted a cohort study to investigate whether polymorphisms in p53 at codon 72 are associated with tumor response and survival time of advanced nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. The study population included 127 subjects with NPC who were enrolled at Binzhou Medical University between September 2008 and December 2009... Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.19.9
- DOI:
- 10.4238/2014.December.19.9
Systematic review of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using free fetal DNA in maternal plasma
Authors: H. Yang, H.B. Xu, T.T. Liu and X.L. He
We evaluated the system accuracy of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using cell-free fetal DNA in maternal plasma. Previous studies were searched in the MEDLINE database using the following keywords: “prenatal” and “aneuploidy” and “noninvasive or non-invasive” and “maternal&.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.1
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.1
Genetic diversity based on SSR analysis of the cultured snakehead fish, Channa argus, (Channidae) in China
Authors: S.-R. Zhu, J.-L. Li, N. Xie, L.-M. Zhu, Q. Wang and G.-H. Yue
The snakehead fish Channa argus is an important food fish in China. We identified six microsatellite loci for C. argus. These six microsatellite loci and four other microsatellite markers were used to analyze genetic diversity in four cultured populations of C. argus (SD, JX, HN, and ZJ) and determin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.February.13.6
- DOI:
- 10.4238/2014.February.13.6
Cytogenetic characterization of Crenicichla (Pisces, Perciformes, Cichlidae) of the Igua�§u River
Authors: S.M.H.K. Mizoguchi, A.L.B. Portela-Castro, I.C. Martins-Santos
Three populations of the genus Crenicichla, namely Crenicichla iguassuensis, Crenicichla sp 1 and Crenicichla sp 2, from the Iguaçu River, were analyzed cytogenetically, and their nucleolus organizer regions, constitutive heterochromatin distribution and chromomycin A3 markings were studied. Karyotype analyses showed a .. Read More»
- Genet. Mol. Res. 6(3):