Elucidating the function and tolerance mechanism of gamma delta (�³ �´) T cells in a Helicobacter pylori infection model
Authors: T.E. Chen, X.M. Xu, P. Liu, S.Y. Liang and W.X. Lv
In this study, the functions and mechanisms of γ δ T cells were analyzed in patients infected with Helicobacter pylori. Peripheral blood was collected from gastritis patients in the Gastroenterology Department of Ningbo No. 2 Hospital. Preliminary analyses revealed 24 H. pylori-positive and 17 H. pylori-negative patients. The wild-type and &ga.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.16
Genetic diversity and relationships among different tomato varieties revealed by EST-SSR markers
Authors: N.K. Korir, W. Diao, R. Tao, X. Li, E. Kayesh, A. Li, W. Zhen and S. Wang
The genetic diversity and relationship of 42 tomato varieties sourced from different geographic regions was examined with EST-SSR markers. The genetic diversity was between 0.18 and 0.77, with a mean of 0.49; the polymorphic information content ranged from 0.17 to 0.74, with a mean of 0.45. This indicates a fairly high degree .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.3
- DOI:
- 10.4238/2014.January.8.3
Activation of p38-mitogen-activated protein kinase contributes to ischemia reperfusion in rat brain
Authors: Y.Q. Song, H.L. Zou, Y.J. Zhao, L.Q. Yu, Z.X. Tan and R. Kong
Inflammation plays an important role in cerebral ischemia reperfusion, which can cause severe damage to the brain and may lead to cerebral hemorrhage transformation. p38-mitogen-activated protein kinase (p38mapk) has been implicated in the etiology of a number of diseases because it is a cause of inflammation, but comparatively little research has been ca.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038492
- DOI:
- 10.4238/gmr.15038492
Detection of aneuploidies in spontaneous abortions by quantitative fluorescent PCR with short tandem repeat markers: a retrospective study
Authors: F.F. Coelho, F.K. Marques, M.S. Gon�§alves, V.C.O. Almeida, E.C.C. Mateo and A.C.S. Ferreira
Approximately 10-15% of all pregnancies end in spontaneous abortions. Many factors can lead to embryonic loss; however, it has been well established that over 50% of all miscarriages result from chromosomal abnormalities, primarily aneuploidies (>96%). Identifying the cause of miscarriage can significantly reduce the psychological stress in women, and .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038617
- DOI:
- 10.4238/gmr.15038617
An efficient regeneration protocol for Agrobacterium-mediated transformation of melon (Cucumis melo L.)
Authors: H.J. Zhang, P. Gao, X.Z. Wang and F.S. Luan
An efficient selection and plant regeneration protocol for Agrobacterium-mediated transformation, using cotyledon node zone-stem connection region of melon, has been developed. The new Agrobacterium-mediated transformation methodology, independent of organ culture, used the entire germinated seed as explants. The transformatio.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.4
- DOI:
- 10.4238/2014.January.8.4
Study of the cytogenetic effects of occupational exposure to pesticides on sanitation workers in Belo Horizonte, Brazil
Authors: F.S.G. Kehdy, E.M.M. Cerqueira, M.B. Bonjardim, R.M. Camelo, M.C.L. Castro
Sanitation workers handling pesticides in the control of disease vectors constitute an occupationally exposed population to genotoxic substances. The aim of the present study was to investigate the relation between the occupational exposure to various pesticides and the presence of cytogenetic damage. Fifty-nine men were selec.. Read More»
- Genet. Mol. Res. 6(3):
In silico identification and characterization of the WRKY gene superfamily in pepper (Capsicum annuum L.)
Authors: Y. Cheng, Z.P. Yao, M.Y. Ruan, Q.J. Ye, R.Q. Wang, G.Z. Zhou, J. Luo, Z.M. Li, Y.J. Yang and H.J. Wan
The WRKY family is one of the most important transcription factor families in plants, involved in the regulation of a broad range of biological roles. The recent releases of whole-genome sequences of pepper (Capsicum annuum L.) allow us to perform a genome-wide identification and characterization of the WRKY family. In this study, 61 CaWRKY proteins were .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038675
- DOI:
- 10.4238/gmr.15038675
DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population
Authors: J.Y. Huang, J.F. Yang, Q. Qu, J. Qu, F. Liu, F.E. Liu, T. Xiong and S.H. Lu
The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma pati.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.18
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.18
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response
Authors: L. Yang, X.W. Wang, L.P. Zhu, H.L. Wang, B. Wang, T. Wu, Q. Zhao, D.L.X.T. JinSiHan and X.Y. Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorph.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038679
- DOI:
- 10.4238/gmr.15038679
Identification and functional analysis of differentially expressed genes related to obesity using DNA microarray
Authors: J.Y. Du, H. Yang, D.R. Tian, Q.M. Wang and L. He
We looked for differentially expressed genes at different stages of preadipocyte differentiation and examined their functions, based on DNA microarrays of preadipocytes obtained from healthy subjects undergoing cosmetic liposuction. We downloaded gene expression profile GSE25910 from the Gene Expression Omnibus database and id.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.5
- DOI:
- 10.4238/2014.January.8.5