Role of IL-10 and TNF-�± during Mycobacterium tuberculosis infection in murine alveolar macrophages
Authors: J. Shi, B.H. Sun, L.R. Zhou and X.S. Wang
Mycobacterium tuberculosis (Mtb) is known to be responsible for tuberculosis (TB), but the pathogenesis of this disease and the host defense mechanisms involved are, for the most part, poorly understood. In this study, we divided 30 male C57BL/6 mice into control and infection groups, and following injection with physiological saline or Mtb, respectively,.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037819
- DOI:
- 10.4238/gmr.15037819
Molecular characterization of olive cultivars using amplified fragment length polymorphism markers
Authors: S. Ercisli, E. Barut and A. Ipek
We sampled six olive cultivars (Tavli Sati, Sati, Gorvela, Sacakli Otur, Butko, and Otur) from Coruh Valley, located in the northeast part of Turkey, and characterized them using amplified fragment length polymorphism (AFLP) markers. Some morphological and biochemical characteristics are also determined. Six AFLP primer combin.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr576
- DOI:
- 10.4238/vol8-2gmr576
Screening and identification of cucumber germplasm and rootstock resistance against the root-knot nematode (Meloidogyne incognita)
Authors: X.Z. Li and S.X. Chen
Root-knot nematodes (Meloidogyne spp) are destructive agricultural pests that reduce the productivity of cultivated vegetables worldwide, especially when vegetables are cropped continuously in greenhouses. Cucumbers (Cucumis sativus L.), in particular, suffer extensive damage due to root-knot nematodes, and only a few wild spe.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029383
- DOI:
- 10.4238/gmr16029383
Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population
Authors: H.M. Wang, N.F. Li, J. Hong, L. Zhou and J.H. Chang
Genetic variation is thought to contribute to etiology of metabolic syndrome (MS). Neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) is a candidate gene for MS. This study investigated the relationship between variations of NEDD4L and MS in the Kazakh, which is an ideal population to study the .. Read More»
- Genet. Mol. Res. 12(1):
- 2014.January.8.1
- DOI:
- 10.4238/2014.January.8.1
Determination of micronucleus frequency by acridine orange fluorescent staining in peripheral blood reticulocytes of mice treated topically with different lubricant oils and cyclophosphamide
Authors: C.R. Oliveira-Martins, C.K. Grisolia
To ascertain whether used and re-refined lubricant oil absorbed through the skin can produce a genotoxic effect or cytotoxicity in mouse bone marrow cells, we examined the induction of micronucleated erythrocytes of peripheral blood after cutaneous application. Both re-refined and used lubricant oils showed a weak but signific.. Read More»
- Genet. Mol. Res. 6(3):
Effect of gene transfection timing on TGF-�²1 expression in rabbit mandibular distraction gap
Authors: M-K. Xie, C-B. Hu, B. Zhou and G-P. Wu
Transforming growth factor-β1 (TGF-β1) is a member of the TGF-β superfamily, and plays an important role in promoting various stages of intramembranous and endochondral bone formation. It is one of the major growth factors that influence new bone formation in the distraction gap during distraction osteogenesis (.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029330
- DOI:
- 10.4238/gmr16029330
Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure
Authors: Y.X. Lei, Q. Lu, C. Shao, C.C. He, Z.N. Lei and Y.Y. Lian
We aimed to evaluate the toxicity of long-term exposure to different cadmium (Cd) doses in rats and expression profiles of DNA repair-related genes. The model rats were exposed to different concentrations of CdCl2 for 3 months, and 5 DNA repair-related genes - hMSH2, MLH1, XRCC1, hOGG1, ERCC1 - were cloned in different tissues, including the liver, kidney.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.5
- DOI:
- 10.4238/2015.January.26.5
Phenotypic diversity of starch granules in cassava germplasm
Authors: L.M. Vasconcelos, A.C. Brito, C.D. Carmo, P.H.G.A. Oliveira and E.J. Oliveira
Demand for the development of cassava varieties with different native starches has guided the search for these characteristics in the germplasm of Manihot esculenta Crantz. Therefore, the objective of this study was to estimate the genetic diversity of cassava accessions for root and starch granule characteristics to guide the.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029276
- DOI:
- 10.4238/gmr16029276
DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity
Authors: M. Santos, L.L. Maia, C.V.M. Silva, G.T. Peterle, A.M.C. Mercante, F.D. Nunes, M.B. Carvalho, E.H. Tajara, I.D. Louro and A.M.A. Silva-Conforti
Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cance.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.13
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.13
Identification of three distinguishable phenotypes in golden retriever muscular dystrophy
Authors: C.E. Ambr�³sio, L. Fadel, T.P. Gaiad, D.S. Martins, K.P.C. Ara�ºjo,E. Zucconi, M.P. Brolio, R.F. Giglio, A.C. Morini, T. Jazedje,T.R. Froes, M.L.T. Feitosa, M.C. Valadares, P.C.B. Beltr�£o-Braga,F.V. Meirelles and M.A. Miglino
Duchenne muscular dystrophy (DMD) is a human disease characterized by progressive and irreversible skeletal muscle degeneration caused by mutations in genes coding for important muscle proteins. Unfortunately, there is no efficient treatment for this disease; it causes progressive loss of motor and muscular ability until death.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr581
- DOI:
- 10.4238/vol8-2gmr581