Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury
Authors: P. Zhu, M.Y. Zhao, X.H. Li, Q. Fu, Z.F. Zhou, C.F. Huang, X.S. Zhang, H.L. Huang, Y. Tan, J.X. Li, J.N. Li, S. Huang, M. Ashraf, C. Lu, J.M. Chen, J. Zhuang and H.M. Guo
We evaluated changes in BAX and BCL2 expression levels after spinal cord ischemia/reperfusion injury (SCII) and hypothermia during operations in rats. Eighty rats were divided into four groups: Group A (N = 20, 18°C); Group B (N = 20, 28°C); Group C (N = 20, room temperature); and Group D (N = 20, sham operation control). Spinal cord ischemia was .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.10
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.10
Identification of Turkish and standard apple rootstocks by morphological and molecular markers
Authors: A. Koc, M. Akbulut, E. Orhan, Z. Celik, S. Bilgener and S. Ercisli
Two local (Vezir-1 and Vezir-2) and two standard (M9 and MM106) clonal apple rootstocks were compared using both morphological and molecular markers. International Union for the Protection of New Varieties of Plants criteria were used for morphological evaluation, which did not clearly separate these rootstocks. We tested 47 r.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr600
- DOI:
- 10.4238/vol8-2gmr600
Genetic progress in sunflower crop in Rio Grande do Sul State, Brazil
Authors: D.N. Follmann, A. Cargnelutti Filho, L.H. Lorentz, A.A. Boligon,M. Caraffa and C.A. Wartha
The sunflower has adaptability to growing regions with different climatic and soil characteristics, showing drought tolerance and high-quality oil production. The State of Rio Grande do Sul is the third largest sunflower producer in Brazil, with research related to the sunflower breeding initiated after the decade of 1950. The.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029520
- DOI:
- 10.4238/gmr16029520
Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus
Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang
We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.1
- DOI:
- 10.4238/2014.January.3.1
Vegetative compatibility and parasexual segregation in Colletotrichum lindemuthianum, a fungal pathogen of the common bean
Authors: M.A.A. Castro-Prado, C.B. Querol, J.R. Santâ??Anna, C.T. Miyamoto, C.C.S. Franco, C.A. Mangolin, M.F.P.S. Machado
The heterokaryotic and vegetative diploid phases of Colletotrichum lindemuthianum are described using nutritional and biochemical markers. Nitrate non-utilizing mutants (nit), derived from R2047, R89, R73, R65, and R23 isolates, were paired in all possible combinations to obtain heterokaryons. Although pairings R2047/R89, R204.. Read More»
- Genet. Mol. Res. 6(3):
Homing of chloromethylbenzoyl ammonia-labeled bone marrow mesenchymal stem cells in an immune-mediated bone marrow failure mouse model in vivo.
Authors: Y. Xiao, Y. Wang, L. Li, Y.H. Li, Y. Pang, J.Y. Song and Z.J. Jiang
Aplastic anemia is an abnormal immune reaction disease in which T lymphocytes destroy hematopoietic stem and progenitor cells because of immune hyperactivity. Bone marrow mesenchymal stem cells (BMSCs) have hematopoietic supporting and immune regulation functions. This study investigated BMSCs homing in mice transplantation mo.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.3.2
- DOI:
- 10.4238/2014.January.3.2
In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells
Authors: S.J. Peng, J. Li, Y. Zhou, M. Tuo, X.X. Qin, Q. Yu, H. Cheng and Y.M. Li
Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029434
- DOI:
- 10.4238/gmr16029434
A possible way that Ï?C31 integrase regulates the recombination direction
Authors: T.A. Liu, Y.X. Fang, H. Yin and Z.Z. Jing
φC31 integrase encoded by Streptomyces phage can mediate site-specific recombination between phage and host genomes. The recombination direction is generally considered to be accurately regulated, but the regulatory mechanisms involved are still unclear. Recently, some hyperactive mutants of φC31 integrase that can bypass the regulatory steps have.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.4
- DOI:
- 10.4238/2015.January.26.4
Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature
Authors: W. Wang, X.P. Luo, L.X. Cai, Z.R. Cui, X.Y. Luo and R.K. Luo
Polymorphisms in the vitamin D receptor (VDR) gene are associated with idiopathic short stature (ISS) in several countries. This study aimed to identify a possible correlation between polymorphisms in the VDR promoter in Chinese children with ISS and the efficacy of the recombinant human growth hormone (rhGH) treatment. Pre-pubertal children with ISS and .. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.8.12
- DOI:
- http://dx.doi.org/10.4238/2015.September.8.12
Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
Authors: A.C. Targa, A.C.G. C?©sar, P.M. Cury, A.E. Silva
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of ap.. Read More»
- Genet. Mol. Res. 6(3):