Abundance and diversity of resistance genes in the sugarcane transcriptome revealed by in silico analysis
Authors: A.C. Wanderley-Nogueira, N.M. Soares-Cavalcanti, D.A.L. Morais, L.C. Belarmino, A. Barbosa-Silva and A.M. Benko-Iseppon
Resistance genes (R-genes) are responsible for the first interaction of the plant with pathogens being responsible for the activation (or not) of the defense response. Despite their importance and abundance, no tools for their automatic annotation are available yet. The present study analyzed R-genes in the sugarcane expressed.. Read More»
- Genet. Mol. Res. 6(4):
Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis
Authors: X.N. Zhao1, Y.N. Li2 and Y.T. Wang1
Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface marker.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017348
- DOI:
- 10.4238/gmr.15017348
miRNApath: a database of miRNAs, target genes and metabolic pathways
Authors: A.O. Chiromatzo, T.Y.K. Oliveira, G. Pereira, A.Y. Costa, C.A.E. Montesco, D.E. Gras, F. Yosetake, J.B. Vilar, M. Cervato, P.R.R. Prado, R.G.C.C.L. Cardenas, R. Cerri, R.L. Borges, R.N. Lemos, S.M. Alvarenga, V.R.C. Perallis, D.G. Pinheiro, I.T. Silva, R.M. Brand�£o, M.A.V. Cunha, S. Giuliatti and W.A. Silva Jr
MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsicall.. Read More»
- Genet. Mol. Res. 6(4):
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population
Authors: D.Z. Tian, W. Wei and Y.J. Dong
ype I collagen (transcribed by COL1A1 and COL1A2 genes) is important for maintaining vessel wall elasticity and is a critical part of the extracellular matrix. We conducted a case-control study to investigate the role of the COL1A2 rs42524 polymorphism in the development of hypertensive intracerebral hemorrhage. Between January 2012 and December 2014, a t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017369
- DOI:
- 10.4238/gmr.15017369
Marker-trait association analysis for agronomic and compositional traits in sainfoin (Onobrychis viciifolia)
Authors: K. Kempf, C.S. Malisch, C. Grieder, F. Widmer and R. K�¶lliker
Sainfoin (Onobrychis viciifolia) is a perennial forage legume with great potential for use in sustainable agriculture due to its low input requirements, good drought tolerance, and production of forage rich in polyphenolic compounds, which are beneficial for animal health. However, its distribution and cultivation are limited .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019483
- DOI:
- 10.4238/gmr16019483
Molecular cloning and expression pattern of the porcine 5-aminolevulinate synthase 1 (ALAS1) gene and its association with reproductive traits
Authors: L.Q. Liu1, F.E. Li2 and C.Y. Deng2
5-Aminolevulinate synthase 1 (ALAS1) is the first enzyme in the heme biosynthetic pathway and is upregulated in follicular tissue during the early stages of ovulation. In this study, we isolated the complete coding sequence of the porcine ALAS1 gene and its 2-9 intron sequence, identified a single nucleotide polymorphism (SNP; T/C) in intron 9, and develo.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017544
- DOI:
- 10.4238/gmr.15017544
Analysis of specific serum markers of colon carcinoma using a Bhattacharyya-based support vector machine
Authors: W.Y. Yang, G. Shi, L.P. Wu, S.T. Wei, Y.N. Huang, L.X. Tan, R.Z. Yang, C.X. Yan, E.T. Guo, H.Y. Wang, J.Z. Tong, Y. Dong and D.Z. Han
We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019521
- DOI:
- 10.4238/gmr16019521
Impact of early enzyme-replacement therapy for mucopolysaccharidosis VI: results of a long-term follow-up of Brazilian siblings
Authors: J.F. Franco1, D.C. Soares1, L.C. Torres2, G.N. Leal1, M.T. Cunha1,R.S. Honjo1, D.R. Bertola1 and C.A. Kim1
Mucopolysaccharidosis type VI (MPS VI) is an autosomal recessive multisystem lysosomal storage disorder, which is characterized by the deficiency of the enzyme arylsulfatase B encoded by the ARSB gene. Treatment of this disease with enzyme-replacement therapy (ERT) improves the clinical status of and generates hope for MPS VI patients. However, only few r.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017850
- DOI:
- 10.4238/gmr.15017850
Proteinase inhibition using small Bowman-Birktype structures
Authors: Fernandez JH, Mello MO, Galgaro L, Tanaka AS, Silva-Filho MC and Neshich G
Bowman-Birk inhibitors (BBIs) are cysteine-rich and highly cross-linked small proteins that function as specific pseudosubstrates for digestive proteinases. They typically display a “double-headed” structure containing an independent proteinase-binding loop that can bind and inhibit trypsin, chymotrypsin and elasta.. Read More»
- Genet. Mol. Res. 6(4):
Role of inosine triphosphate pyrophosphatase gene variant on fever incidence during zidovudine antiretroviral therapy
Authors: A.V.C. Coelho, S.P.S. Silva, L. Zandon� , G. Stocco, G. Decorti and S. Crovella
Zidovudine, the antiretroviral drug used to treat HIV infection, commonly causes adverse effects, such as systemic fever and gastrointestinal alterations. In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) o.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019373
- DOI:
- 10.4238/gmr16019373