Methylation profile of SNRPN gene and its correlation with weight and chronological age
Authors: N.V. Carobin, F.V.M. Rubatino, M.L. Freitas, V.T. de Oliveira, R.X. Pietra, A.A. Bosco and F.S. Jehee
Genomic imprinting is an important epigenetic phenomenon, wherein genes or gene clusters are marked by DNA methylation during gametogenesis. This plays a major role in several functions of normal cells, including cell differentiation, X chromosome inactivation, and the maintenance of chromatin structure, in mammalian development. The aim of this study was.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.41
- DOI:
- 10.4238/2015.October.28.41
RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders
Authors: M.Q. Wang, Y.L. Huang, J. Huang, J.L. Zheng and G.X. Qian
The aim of this study was to explore the precise role of retinoic acid-inducible gene-I (RIG-I) signaling in human immunodeficiency virus type 1 (HIV-1)-infected macrophages from patients with HIV-1-associated neurocognitive disorders (HAND). Postmortem brain tissues were collected from patients with HIV-1-associated dementia and were compared to samples .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.42
- DOI:
- 10.4238/2015.October.28.42
Molecular cloning and characterization of the pseudorabies virus US1 gene
Authors: M.L. Li J.H. Chen Z.Y. Zhao K.J. Zhang Z. Li J. Li J.Y. Mai X.M. Zhu M.S. Cai
Using polymerase chain reaction, a 1050-bp sequence of the US1 gene was amplified from the pseudorabies virus (PRV) Becker strain genome; identification of the US1 gene was confirmed by further cloning and sequencing. Bioinformatics analysis indicated that the PRV US1 gene encodes a putative polypeptide with 349 amino acids. The encoded protein, designated P.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.22.7
- DOI:
- 10.4238/2013.January.22.7
Regularized quantile regression applied to genome-enabled prediction of quantitative traits
Authors: M. Nascimento, F.F. e Silva, M.D.V. de Resende, C.D. Cruz,A.C.C. Nascimento, J.M.S. Viana, C.F. Azevedo, L.M.A. Barroso
Genomic selection (GS) is a variant of marker-assisted selection, in which genetic markers covering the whole genome predict individual genetic merits for breeding. GS increases the accuracy of breeding values (BV) prediction. Although a variety of statistical models have been proposed to estimate BV in GS, few methodologies h.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019538
- DOI:
- 10.4238/gmr16019538
Genetic diversity in the germplasm of tropical maize landraces determined using molecular markers
Authors: D. Molin C.J. Coelho D.S. M�¡ximo F.S. Ferreira J.R. Gardingo R.R. Matiello
Maize landraces derived from tropical germplasm represent an important source of genetic variability, which is currently poorly understood and under-exploited by Brazilian crop breeding programs. The aims of our study were to a) estimate the genetic diversity across 48 varieties of maize landraces cultivated at different locations in the States of Rio Grande.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.22.8
- DOI:
- 10.4238/2013.January.22.8
Supplemental leucine and isoleucine affect expression of cationic amino acid transporters and myosin, serum concentration of amino acids, and growth performance of pigs
Authors: M. Cervantes-RamÃ?Ârez V. Mendez-Trujillo B.A. Araiza-PiÃ?±a M.A. Barrera-Silva D. GonzÃ?¡lez-Mendoza A. Morales-Trejo
Leucine (Leu) participates in the activity of cationic amino acid (aa) transporters. Also, branched-chain aa [Leu, isoleucine (Ile), and valine (Val)] share intestinal transporters for absorption. We conducted an experiment with 16 young pigs (body weight of about 16 kg) to determine whether Leu and Ile affect expression of aa transporters b0,+ and CAT-1 .. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.24.3
- DOI:
- 10.4238/2013.January.24.3
Genetic diversity and selection of common bean lines based on technological quality and biofortification
Authors: S. de M. Steckling, N.D. Ribeiro, F.D. Arns, H.C. Mezzomo, M.T.D.F. Possobom
The development of common bean cultivars with high technological quality that are biofortified with minerals, is required to meet the demand for food with health benefits. The objectives of this study were to evaluate whether common bean genotypes differ in terms of technological and mineral biofortification traits, to study t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019527
- DOI:
- 10.4238/gmr16019527
Transcriptional activity of an ovarian-specific promoter from rat in dairy goat granulosa cells
Authors: H.-Y. Liu M.-M. Yang Y.-H. Cui T. Ma X.-Q. Liu L. Bai W.-P. Xiao H.-B. Zhao J.-Y. Peng X.-B. Hu B.-Y. Cao
Ovarian-specific promoter 1 (OSP-1) is a retrovirus-like element isolated from the complementary DNA library of rat that has been thought to be specifically expressed in ovary. To exploit this promoter in dairy goat ovary granulosa cells (GCs), OSP-1 from rat was used to construct the reporter vector pOSP-1-EGFP, in which egfp coding for enhanced green fl.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.24.4
- DOI:
- 10.4238/2013.January.24.4
REML/BLUP and sequential path analysis in estimating genotypic values and interrelationships among simple maize grain yield-related traits
Authors: T. Olivoto, M. Nardino, I.R. Carvalho3, D.N. Follmann4, M. Ferrari3, V.J. Szareski5, A.J. de Pelegrin3 and V.Q. de Souza6
Methodologies using restricted maximum likelihood/best linear unbiased prediction (REML/BLUP) in combination with sequential path analysis in maize are still limited in the literature. Therefore, the aims of this study were: i) to use REML/BLUP-based procedures in order to estimate variance components, genetic parameters, and .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019525
- DOI:
- 10.4238/gmr16019525
Drought-tolerant rice germplasm developed from an Oryza officinalis transformation-competent artificial chromosome clone
Authors: R. Liu, H.H. Zhang, Z.X. Chen, M.Q. Shahid, X.L. Fu and X.D. Liu
Oryza officinalis has proven to be a natural gene reservoir for the improvement of domesticated rice as it carries many desirable traits; however, the transfer of elite genes to cultivated rice by conventional hybridization has been a challenge for rice breeders. In this study, the conserved sequence of plant stress-related NAC transcription factors was s.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.29
- DOI:
- 10.4238/2015.October.28.29