Arylamine N-acetyltransferase 2 genotypes in a Mexican population
Authors: L. Taja-Chayeb, J.A. Ag�ºndez, C. Miguez-Mu�±oz, A. Chavez-Blanco and A. Due�±as-Gonzalez
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican popu.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.7
- DOI:
- 10.4238/2012.April.27.7
Study on the effects of blueberry treatment on histone acetylation modification of CCl4-induced liver disease in rats
Authors: W. Zhan, X. Liao, T. Tian, L. Yu, X. Liu, B. Li, J. Liu, B. Han, R.J. Xie, Q.H. Ji and Q. Yang
The objective of this study was to investigate the effects of blueberry treatment on histone acetylation modification of carbon tetrachloride (CCl4)-induced liver disease in rats. Laboratory rats were randomly divided into control, hepatic fibrosis, blueberry treatment, blueberry intervention, and natural recovery groups. Rats.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019188
- DOI:
- 10.4238/gmr16019188
MicroRNA-139 modulates Alzheimer�s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Authors: Y. Tang, J.S. Bao, J.H. Su and W. Huang
Alzheimer’s disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as we.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019166
- DOI:
- 10.4238/gmr16019166
IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population
Authors: R.J. Zhang, X.D. Li, S.W. Zhang, X.H. Li and L. Wu
Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018224
- DOI:
- 10.4238/gmr16018224
Polymorphism in the third intron of the interferon-�³ gene is associated with susceptibility to multiple sclerosis
Authors: X.L. Wang, F.R. Meng, X. Wang, S.H. Wang and L. Guo
The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16017538
- DOI:
- 10.4238/gmr16017538
Osteoblast differentiation of rabbit adipose-derived stem cells by polyethylenimine-mediated BMP-2 gene transfection in vitro
Authors: Q.F. Wang, Y. Huang, G.C. He, H.S. Wang, Z.H. Chen, X.H. Cai, Y.H. Xie and Q. Liu
The aim of this study was to examine the efficiency of polyethylenimine-mediated transfection of the human bone morphogenetic protein-2 (BMP-2) gene into rabbit adipose-derived stem cells (ADSCs), and its effect on osteoblast differentiation. Adipose tissue was isolated from the necks of adult Japanese white rabbits and cultur.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16015358
- DOI:
- 10.4238/gmr16015358
Reduced levels of genetic variation in Aedes albopictus (Diptera: Culicidae) from Manaus, Amazonas State, Brazil, based on analysis of the mitochondrial DNA ND5 gene
Authors: R.T. Maia1, V.M. Scarpassa2, L.H. Maciel-Litaiff3 and W.P. Tadei2
Aedes albopictus, a mosquito originally from Southeast Asia, is considered to be one of the main vectors of dengue fever, yellow fever and other arboviruses. We examined the genetic variability and population structure of 68 individuals of Ae. albopictus collected from five neighborhoods of the city of Manaus, based on the mitochondrial gene cod.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr624
- DOI:
- 10.4238/vol8-3gmr624
Genetic characterization of the mite Varroa destructor (Acari: Varroidae) collected from honey bees Apis mellifera (Hymenoptera, Apidae) in the State of Santa Catarina, Brazil
Authors: R. Strapazzon, F.E. Carneiro, J.C.V. Guerra Jr. and G. Moretto
The mite Varroa destructor is an ectoparasite that is considered a major pest for beekeeping with European honey bees. However, Africanized bee colonies are less threatened by this ectoparasite, because infestation levels remain low in these bees. The low reproductive ability of female mites of the Japanese biotype (J), introduced to Brazil early in .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr567
- DOI:
- 10.4238/vol8-3gmr567
Genetic correlations between mature cow weight and productive and reproductive traits in Nellore cattle
Authors: I.C. Regatieri A.A. Boligon F. Baldi L.G. Albuquerque
We investigated genetic associations between mature cow weight (MW) and weaning weight (WW), yearling weight (YW), weight gain from birth to weaning (GBW), weight gain from weaning to yearling (GWY), weaning hip height (WHH), yearling hip height (YHH), scrotal circumference (SC), and age at first calving (AFC). Data from 127,104 Nellore animals born between .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.10.4
- DOI:
- 10.4238/2012.May.10.4
Effects of alendronate on osteoporosis treatment and levels of related cytokines
Authors: C.T. Liu, X.J. Yuan, G.C. Gao
Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treate.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019485
- DOI:
- 10.4238/gmr16019485