Generation of a preliminary bovine gene atlas, using expression clustering to annotate gene function
Authors: O.M. Keane1,3, N. Maqbool2, A.F. McCulloch2, J.C. McEwan2 and K.G. Dodds2
Genes whose products function in a common biological process are often co-regulated. When regulation occurs at the transcriptional level, co-expressed genes can be detected globally by expression arrays or by sequencing non-normalized cDNA libraries. We examined bovine gene expression in 27 tissues using non-normalized cDNA library sequencing. Contigs wer.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr594
- DOI:
- 10.4238/vol8-3gmr594
Gene expressions levels of 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPase�² in gill tissue of Mugil cephalus acclimated to low salinity
Authors: L. Li, M. Jiang and X.Q. Shen
Fishes adapt to salinity changes primarily through osmotic pressure regulation, a process often associated with several genes, including 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ. The present study investigated the differential expression of genes 14-3-3a, NKCCla, APO-14, and Na+-K+-ATPaseβ in the gill tissue of Mu.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019444
- DOI:
- 10.4238/gmr16019444
Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review
Authors: P.H.S. Klinger, A.F. Andrade, L.E.A. Delsin, R.G.P. Queiroz, C.A. Scrideli, L.G. Tone and E.T. Valera
Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigene.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019412
- DOI:
- 10.4238/gmr16019412
Antifungal activity, yield, and composition of Ocimum gratissimum essential oil
Authors: F.B.M. Mohr, C. Lermen, Z.C. Gazim, J.E. Gon�§alves, O. Alberton
Ocimum gratissimum L. or clove basil, belongs to the Lamiaceae family, has various desirable uses and applications. Beyond its aromatic, seasoning, and medicinal applications, this plant also has antimicrobial activity. This study was aimed at assessing the antifungal activity, yield, and composition of the essential oil (EO) .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019542
- DOI:
- 10.4238/gmr16019542
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes
Authors: J. Zekri, A. Al-Shehri, M. Mahrous, S. Al-Rehaily, T. Darwish, S. Bassi, H. El Taani, A. Al Zahrani, S. Elsamany, J. Al-Maghrabi and B.B. Sadiq
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019369
- DOI:
- 10.4238/gmr16019369
Path analysis of the energy density of wood in eucalyptus clones
Authors: A.M. Couto, P.E. Teodoro, P.F. Trugilho
Path analysis has been used for establishing selection criteria in genetic breeding programs for several crops. However, it has not been used in eucalyptus breeding programs yet. In the present study, we aimed to identify the wood technology traits that could be used as the criteria for direct and indirect selection of eucalyp.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019536
- DOI:
- 10.4238/gmr16019536
Maize endophytic bacteria as mineral phosphate solubilizers
Authors: C.S. de Abreu, J.E.F. Figueiredo, C.A. Oliveira, V.L. dos Santos, E.A. Gomes, V.P. Ribeiro, B.A. Barros, U.G.P. Lana and I.E. Marriel
In the present study, we demonstrated the in vitro activity of endophytic phosphate-solubilizing bacteria (PSB). Fifty-five endophytic PSB that were isolated from sap, leaves, and roots of maize were tested for their ability to solubilize tricalcium phosphate and produce organic acid. Partial sequencing of the 16S rRNA-encodin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019294
- DOI:
- 10.4238/gmr16019294
Tumor-suppressive role of Kruppel-like factor 4 (KLF-4) in colorectal cancer
Authors: D.H. Xiu, Y. Chen, L. Liu, H.S. Yang and G.F. Liu
Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC t.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019272
- DOI:
- 10.4238/gmr16019272
Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine
Authors: S.M.A. Limeiras, B.C. Oliveira, L.R. Pessatto, J.R. Pesarini, C.A.L. Kassuya, A.C.D. Monreal, W.B. Cantero, R. Antoniolli-Silva, A.C.M.B. Antoniolli-Silva, M.E.A. Stefanello, R.J. Oliveira
The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment,.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019518
- DOI:
- 10.4238/gmr16019518
PIT1 gene polymorphism in Pietrain and Large White pigs after divergent selection
Authors: A.C.P. Silveira1, T.F. Braga1, J.F. Almeida2, R.C. Antunes1,P.F.A. Freitas1, A.S.M. Cesar1 and E.C. Guimar�£es1
We examined the polymorphisms in the PIT1 gene of 103 pigs and compared their frequencies in the maternal and paternal lineages of the Pietrain and Large White breeds, which have undergone divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by PCR and genotyped by RFLP, using the restriction enzyme R.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr609
- DOI:
- 10.4238/vol8-3gmr609