Association between the interleukin-1�² C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population
Authors: H.F. Wang, F.Q. He, C.J. Xu, D.M. Li, X.J. Sun, Y.T. Chi and W. Guo
The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019315
- DOI:
- 10.4238/gmr16019315
Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study
Authors: G.G. Ceylan1, C. Ceylan2 and H. Elyas3
Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complet.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr616
- DOI:
- 10.4238/vol8-3gmr616
Genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene in Chinese patients with gastric cancer
Authors: J. Liu X. Li N. Yu Y.-Q. Yang X. Li Z.-Y. Ye J.-C. Li
We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability and loss of heterozygosity of the PAI-1 gene locus D7S515, D7S471 .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.11
- DOI:
- 10.4238/2012.May.18.11
Multivariate statistics applied to the reaction of common bean plants to parasitism by Meloidogyne javanica
Authors: L.N.S. Santos, P.D.S. Cabral, G.A.R. Neves, F.R. Alves, M.B. Teixeira1, F.N. Cunha1 N.F. Silva
The availability of common bean cultivars tolerant to Meloidogyne javanica is limited in Brazil. Thus, the present study aimed to evaluate the reactions of 33 common bean genotypes (23 landrace, 8 commercial, 1 susceptible standard and 1 resistant standard) to M. javanica, employing multivariate statistics to discriminate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019420
- DOI:
- 10.4238/gmr16019420
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells
Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019269
- DOI:
- 10.4238/gmr16019269
A genomic parasite in the evolution of metazoan development
Authors: H.F. Hoenigsberg* and C. Sanabria
It is a challenge to understand how development emerged as a mechanism to dismantle and dismiss the intromission of foreign parasites in order to consolidate a higher-level multicellular unit of selection where more heritable variations in fitness, required for complex organization, can be procured. Levels in biological hierarchy genes, networks of genes,.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr571
- DOI:
- 10.4238/vol8-3gmr571
Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle
Authors: Y. Yang J.M. Huang Z.H. Ju Q.L. Li L. Zhou R.L. Li J.B. Li F.X. Shi J.F. Zhong C.F. Wang
The complement system helps in the direct lysis of invading pathogens and modulates phagocytic, humoral and cellular immune responses. Complement 4 is a critical component in complement activity and protection against many bacterial pathogens because it is essential to classical and lectin activation pathways. We used reverse transcription and PCR to investi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.12
- DOI:
- 10.4238/2012.May.18.12
Identification of markers tightly linked to tomato yellow leaf curl disease and root-knot nematode resistance by multiplex PCR
Authors: S.X. Chen J.N. Du L.N. Hao C.Y. Wang Q. Chen Y.X. Chang
Seven different commercial F1 hybrids and two F2 populations were evaluated by multiplex PCR to identify plants that are homozygous or heterozygous for Ty-1 and Mi, which confer resistance to tomato yellow leaf curl disease and root-knot nematode, respectively. The Ty-1 and Mi markers were amplified by PCR and identified by digestion of the amplicons with th.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.4
- DOI:
- 10.4238/2012.July.10.4
Origin of a polyploid accession of Brachiaria humidicola (Poaceae: Panicoideae: Paniceae)
Authors: K.R. Boldrini1, P.L. Micheletti1, P.H. Gallo1, A.B. Mendes-Bonato1,M.S. Pagliarini1 and C.B. Valle2
Brachiaria humidicola, a species adapted to poorly drained and infertile acid soils, is widely used throughout the tropics. Cytological characterization of 54 accessions of B. humidicola for breeding purposes revealed 2n = 36, 42, and 54 chromosomes. One accession (H030), with 2n = 42 chromosomes, showed a different meiotic behavior. In most accessions fr.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr617
- DOI:
- 10.4238/vol8-3gmr617
Association between PPAR�³2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China
Authors: L.P. Wang L.R. Zhao H.W. Cui M.R. Yan L. Yang X.L. Su
Activation of the peroxisome proliferator-activated receptor g (PPARg) improves insulin sensitivity and inhibits atherosclerosis. Whether PPARg2 Pro12Ala polymorphism affects myocardial infarction is not clearly understood. We investigated a possible association of PPARg2 Pro12Ala polymorphism with obesity and myocardial infarction in Han Chinese in Hohho.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.13
- DOI:
- 10.4238/2012.May.18.13