KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis
Authors: H.G. Han, H.S. Wang, Z. Yin, H. Jiang, M. Fang and J. Han
KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconc.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.12
- DOI:
- 10.4238/2014.October.20.12
Mutation analysis of four Chinese families with pure hereditary spastic paraplegia: pseudo- X-linked dominant inheritance and male lethality due to a novel ATL1 mutation
Authors: N. Zhao, Y. Sui, X.F. Li, W. Liu, Y.P. Lu, W.H. Feng, C. Ma, Y.W. Wang, H.X. Bao, F. Huang, H. Wang, D.X. Yi, W.T. Han and M. Jiang
We studied four Chinese families with pure hereditary spastic paraplegia (HSP) to investigate the clinical features and associated genetic mutations. Linkage analysis was performed for all families to map the disease locus onto autosomal chromosomes, and related loci involved in HSP on the X chromosome were also examined. Polymerase chain reaction (PCR) s.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.33
- DOI:
- 10.4238/2015.November.18.33
Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore
Authors: T. Song, J. Liu, X. Tao and J.G. Deng
The aim of this study was to investigate the influence of atorvastatin on the opening of the mitochondrial permeability transition pore (MPTP) and the expression of cytochrome C (Cyt C) in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by the suture-occluded method with ischemia for .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.5
- DOI:
- 10.4238/2014.December.18.5
Protective effect of thymoquinone on cholestatic rats with liver injury
Authors: L.Y. Kong, G.P. Li, P. Yang and Z. Xi
The aim of this study was to investigate the protective effects of thymoquinone treatment on cholestatic rats with liver injury. Thirty-two Sprague-Dawley rats were divided randomly into four groups: normal control, bile duct ligation model control, low-dose thymoquinone (25 mg/kg), and high-dose thymoquinone (50 mg/kg). Thymo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.13
- DOI:
- 10.4238/2015.October.9.13
Mitochondrial D-loop nucleotide diversity in Astyanax (Osteichthyes, Characidae) from the upper Paran�¡ and upper Paraguay River basins
Authors: A.J. Prioli, V.A. Carlo, T.V. Soria, S.M.A.P. Prioli, C.S. Pavanelli, R.A. Prioli, V.N. Gomes, H.F. J�ºlio Jr. and L.M. Prioli
The morphological discrimination between the species Astyanax altiparanae and A. asuncionensis of the upper Paraná River and Paraguay River basins, respectively, has always been difficult. Two D-loop haplogroups of A. altiparanae are known, one with the presence (AltoPR) or the absence (AltoPR-D) of a 32-bp block simila.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.5
- DOI:
- 10.4238/2012.April.27.5
Etiological factors, prognostic assessment, and outcomes of patients with acute kidney injury and multiple organ dysfunction syndrome
Authors: Z. Gao1, D.W. Mu2, L. Guo3, X.M. Li1 and L.D. Lun1
This clinical study assessed the etiological factors implicated in acute kidney injury (AKI). AKI has a complicated etiology with many serious complications. Understanding the interactions among these factors will help physicians treat patients with AKI. This retrospective study analyzed the etiological factors and assessed the incidence and outcome of 12.. Read More»
- Genet. Mol. Res. 13(4):
- /2014.October.20.13
- DOI:
- /10.4238/2014.October.20.13
Association between CSN3 and BCO2 gene polymorphisms and milk performance traits in the Czech Fleckvieh cattle breed
Authors: P. Bartonova, I. Vrtkova, K. Kaplanova and T. Urban
Daily milk, fat and protein yield and amount of somatic cells in cow milk are very important factors that influence milk performance traits. An association between polymorphisms in the kappa casein (CSN3) gene and milk production, composition and technical properties has been previously reported; however, this type of informat.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.4
- DOI:
- 10.4238/2012.April.27.4
Cloning and prokaryotic expression of the porcine lipasin gene..
Authors: M.M. Li* J. Geng, Y.J. Guo, X.Q. Jiao, W.F. Lu, H.S. Zhu, Y.Y. Wang and G.Y. Yang
Lipasin has recently been demonstrated to be involved in lipid metabolism. In this study, two specific primers were used to amplify the lipasin open reading frame from porcine liver tissue. The polymerase chain reaction product was cloned to a pGEM®-T Easy Vector, digested by SalI and NotI, and sequenced. The lipasin fragment was then cloned to a pET2.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.34
- DOI:
- 10.4238/2015.November.18.34
Novel polymorphic microsatellite markers isolated from the pen shell Atrina pectinata (Mollusca: Bivalvia: Pinnidae)
Authors: B. Wu, L.J. Bai, A.G. Yang, L.Q. Zhou and Z.H. Liu
In this study, we isolated 21 novel polymorphic microsatellite DNA loci from the pen shell Atrina pectinata using magnetic-bead hybridization enrichment. The characteristics of these loci were tested using a population of 30 individuals collected from the Penglai coast, Shandong Province. The number of alleles ranged from 2 to 13, and polymorphism informa.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.18.6
- DOI:
- 10.4238/2014.December.18.6
DNA isolation protocol for the medicinal plant lemon balm (Melissa officinalis, Lamiaceae)
Authors: S. Ghaffariyan, S.A. Mohammadi and S. Aharizad
Lemon balm (Melissa officinalis) is a medicinal plant that is widely used as a sedative or calmant, spasmolytic and antibacterial agent and sleep aid. This has led to a high demand for lemon balm products, resulting in the extinction of this species in some of its natural habitats. Molecular techniques have increasingly been u.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.3
- DOI:
- 10.4238/2012.April.27.3