Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice
Authors: C.A. Gon�§alves, N.L. Silva, M.O. Mauro, N. David, A.L. Cunha-Laura, S.A. Auharek, A.C.D. Monreal, M.C. Vieira, D.B. Silva, F.J.L. Santos, J.M. Siqueira and R.J. Oliveira
Plants such as Annona nutans used in folk medicine have a large number of biologically active compounds with pharmacological and/or toxic potential. Moreover, pregnant women use these plants indiscriminately, mainly in the form of teas, without being aware of the harm that they could cause to the health of the embryo/fetus. Th.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.11.3
- DOI:
- http://dx.doi.org/10.4238/2014.June.11.3
Cloning and functional analysis of the chitinase gene promoter in peanut
Authors: X.L. Chen, R.T. Song, M.Y. Yu, J.M. Sui, J.S. Wang and L.X. Qiao
Chitinase is an important pathogenesis-related protein in plants, and it can accumulate when induced by salicylic acid (SA) or other elicitors. Here, we found that chitinase mRNA levels were 4.5-times greater when peanut seedlings were sprayed with 1.5 mM SA, as compared to water. The upstream promoter sequence of the chitinas.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.15
- DOI:
- 10.4238/2015.October.19.15
GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer
Authors: A.L. Oliveira, F.F. Oliveira Rodrigues, R.E. dos Santos, R.L. Rozenowicz and M. Barbosa de Melo
The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.9
- DOI:
- 10.4238/2014.January.22.9
Improvements in neuroelectrophysiological and rear limb functions in rats with spinal cord injury after Schwann cell transplantation in combination with a C5a receptor antagonist
Authors: S.-Q. Zhang, M.-F. Wu, C.-G. Peng, Y. Lv, D.-K. Wu, J. Liu and Q. Yang
We measured the effect of Schwann cell transplantation and complement factor 5a (C5a) receptor antagonist on nerve function recovery in rats with spinal cord injury. Experimental spinal cord injury was induced in eighty Wistar rats and these were randomly divided into four treatment groups: culture medium and saline injection .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.4
- DOI:
- 10.4238/2015.November.25.4
A SNP in the 3'-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484
Authors: Q.L. Li, Z.F. Zhang, P. Xia, Y.J. Wang, Z.Y. Wu, Y.H. Jia, S.M. Chang and M.X. Chu
The heat shock transcription factor 1 gene (HSF1) plays a key role in the heat stress response. We previously found a single nucleotide polymorphism (SNP) in the 3'-untranslated region (g.4693G>T) of HSF1 that was related to thermo tolerance in Chinese Holstein cattle through association analysis. However, it is not known w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.18
- DOI:
- 10.4238/2015.October.19.18
Homology-based analysis of the GRAS gene family in tobacco
Authors: Y.Q. Chen, S.S. Tai, D.W. Wang, A.M. Ding, T.T. Sun, W.F. Wang and Y.H. Sun
Members of the GRAS gene family are important transcriptional regulators. In this study, 21 GRAS genes were identified from tobacco, and were classified into eight subgroups according to the classification of Arabidopsis thaliana. Here, we provide a preliminary overview of this gene family in tobacco, describ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.7
- DOI:
- 10.4238/2015.November.25.7
Effects of exogenous 5-aminolevulinic acid on PIP1 and NIP aquaporin gene expression in seedlings of cucumber cultivars subjected to salinity stress
Authors: F. Yan, D. Qu, Y.Y. Zhao, X.H. Hu, Z.Y. Zhao, Y. Zhang and Z.R. Zou
Aquaporins play a direct role in plant water relation under salt stress, but the effects of 5-aminolevulinic acid (ALA) on aquaporin gene expression in salt-treated plants remain unknown. This study investigated the potential effects of exogenous ALA (50 mg/dm3) on aquaporin expression levels under salt stress (75 mM NaCl) in .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.12
- DOI:
- 10.4238/2014.January.22.12
Analysis of diversity and relationships among orchardgrass (Dactylis glomerata L.) accessions using start codon-targeted markers
Authors: L.F. Jiang, X. Qi, X.Q. Zhang, L.K. Huang, X. Ma and W.G. Xie
Orchardgrass, or cocksfoot, is an important perennial forage grass worldwide. The comprehensive understanding of orchardgrass accessions will benefit germplasm collection and breeding progress, and it will enhance efforts to improve forage yield and quality. Therefore, 24 novel, simple, polymorphic, and reliable start codon-ta.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.11.4
- DOI:
- http://dx.doi.org/10.4238/2014.June.11.4
Comparative analysis of polygalacturonase in the fruit of strawberry cultivars
Authors: H.C. Zhou, G. Li, X. Zhao and L.J. Li
The role of polygalacturonase (PG) in the development, ripening, and softening of fruit from two strawberry cultivars with different flesh firmness and softening characteristics was compared. Changes in PG activity and gene expression during development, ripening and softening were measured. The PG genes from each cultivar wer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.21
- DOI:
- 10.4238/2015.October.19.21
Establishment of a hepatocyte steatosis model using Chang liver cells
Authors: D. Yan, Q.L. Dou, Z. Wang and Y.Y. Wei
The objective of this study was to explore the experimental conditions for hepatocellular steatosis models of Chang liver cells induced by oleic acid (OA). For that, Chang liver cells were induced by different concentrations of OA for different periods. The MTT assay was used to detect hepatic cell activity, the Oil Red O stai.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.10
- DOI:
- 10.4238/2015.November.25.10