Comparative cytogenetics of spiny rats of the genus Proechimys (Rodentia, Echimyidae) from the Amazon region
Authors: E.S. Eler, M.N.F. da Silva, C.E.F. Silva and E. Feldberg
We made a comparative analysis of the cytogenetics of spiny rat species of the genus Proechimys collected from several sites of the Madeira River basin (Amazonas State, Brazil) and Jari River valley (Pará State, Brazil). Individuals were assigned to three groups based on diploid and fundamental numbers: 2n = 28, FN = 46.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.3.5
- DOI:
- 10.4238/2012.April.3.5
Indirect selection of industrial tomato genotypes rich in zingiberene and resistant to Tuta absoluta Meyrick
Authors: I.P. Lima, J.T.V. Resende, J.R.F. Oliveira, M.V. Faria2, N.C.V. Resende and R.B. Lima Filho
Obtaining tomato cultivars resistant to pests through interspecific crosses between commercial cultivars and wild accessions is an important tool in integrated pest management. The aim of this study was to select tomato genotypes with high zingiberene (ZGB) levels that are resistant to the South American tomato moth (Tuta .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.16
- DOI:
- 10.4238/2015.November.24.16
Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer
Authors: X.J. Zhang, P. Liu and F. Zhu
We aimed to investigate the association between genetic variants of the DNA repair genes XPG, CSB, XPC, CCNH, and MMS19L in the nucleotide excision repair (NER) pathway and risk of prostate cancer in a population in China. This study included 229 patients with newly diagnosed and histopathologically confirmed primary prostate .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.24.20
- DOI:
- 10.4238/2014.January.24.20
Drynaria total flavonoids decrease cathepsin K expression in ovariectomized rats
Authors: X.L. Shi1, C.W. Li2, Q.Z. Wan2, A.Q. Li2, H. Wang1 and K. Liu
This study investigated the effects of Drynaria total flavonoids on cathepsin K serum concentrations and gene expression, biomechanics and bone mineral density (BMD) of the tibial shaft in ovariectomized rat models of osteoporosis, and mechanism in the prevention and cure of osteoporosis. Seventy-two female Sprague-Dawley rats.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.17
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.17
Role of survivin in the pathogenesis of papillary thyroid carcinoma
Authors: J.Y. Li, J. Shi, J.F. Sang, Y.Z. Yao, X.C. Wang and L. Su
The purpose of this study was to assess the correlation between the survivin gene and the occurrence and pathogenesis of papillary thyroid carcinoma (PTC). Sixty patients with PTC and no preoperative chemotherapy were recruited for the study and 30 thyrophyma patients receiving operative treatment in Drum Tower Hospital (Nanji.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.19
- DOI:
- 10.4238/2015.November.24.19
Huwe1 as a therapeutic target for neural injury
Authors: J. Zhou, Q. Liu M. Mao and Y. Tong
The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer’s disease, and Parki.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.18
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.18
Novel polymorphic microsatellite markers for Bellamya and their application in population genetics of three species
Authors: Q.H. Gu, Q.Q. Cheng, X.J. Li and C.J. Zhou
Bellamya is a widely distributed freshwater snail genus in China; however, its genetic diversity is completely unknown. Sixty-five novel microsatellite loci were isolated and characterized from a microsatellite-enriched library of Bellamya aeruginosa genomic DNA. Most of the 65 loci were successfully amplified. We fou.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.8
- DOI:
- 10.4238/2015.November.25.8
A new single nucleotide polymorphism in the ryanodine gene of chicken skeletal muscle
Authors: A.A. Droval, E. Binneck, S.R.R. Marin, F.G. Pai�£o1, A. Oba, A.L. Nepomuceno and M. Shimokomaki
Some genes affect meat quality in chickens. We looked for polymorphisms in the Gallus gallus α-RyR gene (homologous to RyR 1) that could be associated with PSE (pale, soft and exudative) meat. Because RyR genes are over 100,000 bp long and code for proteins with about 5000 amino acids, primers were designed to amplify a .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.3.4
- DOI:
- 10.4238/2012.April.3.4
Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients
Authors: L. Wang, L.H. Liu, W.H. Tong, M.X. Wang and S.C. Lu
We examined the influence of the cytochrome P450 3A5 (CYP3A5) genes in both donors and recipients on the concentration-dosage ratio (C/D) of tacrolimus in Chinese liver transplant patients. Fifty-one adult liver transplant patients who received tacrolimus were included in this study. The CYP3A5 polymorphism i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.3
- DOI:
- 10.4238/2015.November.25.3
Identification and analysis of a 5-bp indel of a porcine BMP7 gene promoter
Authors: P. Lu, X. Feng, J.S. Zhou, X.B. Liu, Q.X. Chen and M. Li
Bone morphological protein7 (BMP7), a member of the transforming growth factor-β (TGF-β) family, was first identified because of its ability to induce ectopic chondro-osteogenesis in vivo. It also plays a crucial role in the growth, development, and physiological functioning of the reproductive system. Among intra-ov.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.19
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.19