Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas

Authors: P.K. Mishra, S.K. Jatawa, G.V. Raghuram, N. Pathak, A. Jain,A. Tiwari, S. Varshney and K.K. Maudar

Gallbladder carcinoma is an uncommon, but highly malignant tumor, with poor prognostic, and diagnostic manifestations in early stages. The Indian Council of Medical Research reported increased incidence of gallbladder carcinoma in the surviving population of the Bhopal gas tragedy that involved exposure of more than 500,000 pe.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr653

DOI: 10.4238/vol8-4gmr653

Lack of association of C282Y and H63D mutations in the hemochromatosis (HFE) gene with diabetes mellitus type 2 in a case-control study of women in Brazil

Authors: K.B. Gomes, M.G. Carvalho, F.F. Coelho, I.F. Rodrigues, A.L. Soares, D.A. Guimar�£es and A.P. Fernandes

Hereditary hemochromatosis is one of the most common autosomal recessive diseases; it is characterized by excess absorption of iron. Clinically, the major challenge is to diagnose increased iron deposition before irreversible tissue damage has occurred. C282Y and H63D are the main mutations related to hereditary hemochromatosi.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr663

DOI: 10.4238/vol8-4gmr663

Phenotypic and RAPD diversity among 80 germplasm accessions of the medicinal plant isabgol (Plantago ovata, Plantaginaceae)

Authors: N. Singh, R.K. Lal and A.K. Shasany

Plantago ovata, popularly known as isabgol, has great commercial and medicinal importance due to thin rosy white membranous seed husk. Isabgol seeds and husks have emollient, demulcent and laxative properties. We used both biometric and molecular techniques to assess the genetic variability and relatedness of 80 germplasm acce.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr583

DOI: 10.4238/vol8-4gmr583

SSR analysis demonstrates that olive production in the southern Marmara region in Turkey uses a single genotype

Authors: A. Ipek, E. Barut, H. Gulen, A.T. Oz, N.A. Tangu and M. Ipek

The southern Marmara region in Turkey was surveyed to determine the olive cultivars that are used for olive production. Genetic diversity analysis using simple sequence repeat (SSR) markers indicated that the cultivar Gemlik is the major olive cultivar grown in this region, while other olive cultivars are grown only for use as.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr659

DOI: 10.4238/vol8-4gmr659

Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma

Authors: N.P. Anselmo, J.A. Rey, L.O. Almeida, A.C. Cust�³dio,J.R.W. Almeida, C.A. Clara, M.J. Santos and C. Casartelli

Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar function.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr631

DOI: 10.4238/vol8-4gmr631

Salt stress causes a shift in the localization pattern of germin gene expression

Authors: M. Caliskan

The response of plants to biotic and abiotic stress factors involves biochemical, physiological, morphological, and developmental changes. Salt stress has been the subject of extensive studies due to the low salt tolerance of many crop plants. Germin and germin-like gene products are known to be involved in various aspects of .. Read More»

Genet. Mol. Res. 8(4):

Africanized honey bees more efficiently convert protein diets into hemolymph protein than do Carniolan bees (Apis mellifera carnica)

Authors: F.A. Cappelari, A.P. Turcatto, M.M. Morais and D. De Jong

The superiority of Africanized over European honey bees in tropical and subtropical regions of the New World is both well documented and poorly understood. As part of an effort to try to understand the process by which the displacement of European bees occurred, we examined the ability of these two types of bees and of hybrids.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr628

DOI: 10.4238/vol8-4gmr628

An assessment of genetic variability and relationships among wild-grown blackthorn (Prunus spinosa L.) plants based on RAPD markers

Authors: Y. Erturk, S. Ercisli, D. Maghradze, E. Orhan and G. Agar

Prunus spinosa, blackthorn, exists as wild populations that inhabit uncultivated uplands of Coruh Valley in the northeastern part of Turkey; the fruit is used to make preserves. We examined genetic diversity in wild-grown Prunus spinosa; 16 individual plants from wild populations of Coruh Valley were sampled and subjected to R.. Read More»

Genet. Mol. Res. 8(4): vol8-4gmr641

DOI: 10.4238/vol8-4gmr641