First isolation and characterization of genomic SSR markers for the giant red shrimp Aristaeomorpha foliacea (Risso, 1827)

Authors: R. Cannas S. Marcias F. Sacco A. Cau A.M. Deiana

Fourteen microsatellite markers were isolated from the giant red shrimp Aristaeomorpha foliacea (Risso, 1827) using the FIASCO protocol (fast isolation by AFLP of sequences containing repeats). Polymorphism was assessed in 30 individuals from two localities of the western Mediterranean basin (N = 20 from Sardinia and N = 10 from Sicily); nine loci showed .. Read More»

Genet. Mol. Res. 3(4): 2012.August.17.1

DOI: 10.4238/2012.August.17.1

Public sphere and the sustainability of the bioinformatics promise

Authors: Marcelo Leite

The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as .. Read More»

Genet. Mol. Res. 3(4):

Bioinformatics: perspectives for the future

Authors: Luciano da Fontoura Costa

I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex network.. Read More»

Genet. Mol. Res. 3(4):

Using bradykinin-potentiating peptide structures to develop new anti hypertensive drugs

Authors: Jorge Hernandez Fernandez, Goran Neshich and Antonio Carlos M. Camargo

Angiotensin I-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase expressed in endothelial, epithelial and neuroepithelial cells. It is composed of two domains, known as N- and C-domains, and it is primarily involved in blood pressure regulation. Although the physiological functions of ACE are not limited to its cardiovas.. Read More»

Genet. Mol. Res. 3(4):

The olfactory receptor universe - from whole genome analysis to structure and evolution

Authors: Tsviya Olender, Ester Feldmesser, Tal Atarot, Miriam Eisenstein and Doron Lancet

Olfactory receptors (ORs) constitute the largest gene-family in the vertebrate genome. We have attempted to provide a comprehensive view of the OR universe through diverse tools of bioinformatics and computational biology. Among others, we have constructed the Human Olfactory Receptor Data Exploratorium (HORDE, http://bioporta.. Read More»

Genet. Mol. Res. 3(4):

A bioinformatics analysis of alternative exon usage in human genes coding for extracellular matrix proteins

Authors: Noboru Jo Sakabe, Maria Dulcetti Vibranovski and Sandro Jos�© de Souza

Alternative splicing increases protein diversity through the generation of different mRNA molecules from the same gene. Although alternative splicing seems to be a widespread phenomenon in the human transcriptome, it is possible that different subgroups of genes present different patterns, related to their biological roles. An.. Read More»

Genet. Mol. Res. 3(4):

A novel human G protein-coupled receptor is over-expressed in prostate cancer

Authors: Raphael B. Parmigiani, Geraldo S. Magalh�£es, Pedro A.F. Galante,Carina V.B. Manzini, Anamaria A. Camargo and Bettina Malnic

G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the i.. Read More»

Genet. Mol. Res. 3(4):

Splicing factors are differentially expressed in tumors

Authors: Natanja Kirschbaum-Slager, Graziela M.P. Lopes, Pedro A.F. Galante, Gregory J. Riggins and Sandro J. de Souza

Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated,.. Read More»

Genet. Mol. Res. 3(4):