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Publications of : X.M. Che
Human Genetics   Research Article

Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular.. Read More»

Genet. Mol. Res. 16(3): gmr16038961

DOI: 10.4238/gmr16038961

Microbial Genetics   Research Article

Highly specific detection of genetic modification events using an enzyme-linked probe hybridization chip

    M.Z. Zhang, X.F. Zhang, X.M. Chen, X. Chen, S. Wu and L.L. Xu

The enzyme-linked probe hybridization chip utilizes a method based on ligase-hybridizing probe chip technology, with the principle of using thio-primers for protection against enzyme digestion, and using lambda DNA exonuclease to cut multiple PCR products obtained from the sample being tested into single-strand chains for hybridization. The 5'-end amino-labeled probe was fixed onto the aldehyde.. Read More»

Genet. Mol. Res. 14(3): 2015.August.10.10

DOI: 10.4238/2015.August.10.10

Human Genetics   Research Article

Prognostic and assessment value of hyperglycemia and glycosylated hemoglobin in critical patients

    Z.L. Zhang, X.M. Che, Z.H. Bai, W.J. Bu, L. Bai and H.H. Pei

Hyperglycemia is common in critical patients and high blood glucose levels have a negative effect on their prognosis. The aim of this study was to investigate the effect of hyperglycemia and glycosylated hemoglobin (GHb) in critical patients. A total of 648 critical patients were enrolled in the study and received a random blood glucose test when they entered the em.. Read More»

Genet. Mol. Res. 13(3): 2014.January.24.8

DOI: 10.4238/2014.January.24.8

Human Genetics   Research Article

Regulation of the expression of zinc finger protein genes by microRNAs enriched within acute lymphoblastic leukemia-derived microvesicles

    L. Lu, X.M. Chen, H.M. Tao, W. Xiong, S.H. Jie and H.Y. Li

Microvesicles (MVs) are submicrometric membrane fragments that can “engulf” cytoplasmic contents such as microRNAs (miRNAs) from their cellular origin. The study of miRNAs carried within MVs might provide insights into the roles that miRNAs play in the underlying pathophysiologic processes of acute lymphoblastic leu­kemia (ALL). We identified numerou.. Read More»

Genet. Mol. Res. 14(4): 2015.October.5.2

DOI: 10.4238/2015.October.5.2

Animal Genetics   Research Article

RNA-Seq-based transcriptome and the reproduction-related genes for the aphid Schlechtendalia chinensis (Hemiptera, Aphididae)

    P. Liu, Z.X. Yang, X.M. Chen, P. Yang

Chinese galls form on sumac plants (Rhus chinensis) and are used for medicinal and chemical purposes, due to their richness in tannins. The galls are formed by aphids, the most prominent of which is Schlechtendalia chinensis, which forms horn-shaped galls on the winged rachis of R. chinensis. S. chinensis has a complex life cycle, including both R. chinensis and cer.. Read More»

Genet. Mol. Res. 16(1): gmr16019448

DOI: 10.4238/gmr16019448

Human Genetics   Research Article

Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population

    H.B. Gui, X.G. Du, Z.H. Fu and X.M. Chen

We investigate the relationship between IL-18 -607C/A and -137G/C genetic polymorphisms and development of acute pancreatitis in a Chinese population. A total of 153 patients were consecutively recruited from the First Affiliated Hospital of Chongqing Medical University between January 2013 and November 2014. Genotyping of IL-18 -607C/A and -137G/C variants was perf.. Read More»

Genet. Mol. Res. 15(3): gmr.15038394

DOI: 10.4238/gmr.15038394

Human Genetics   Research Article

Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells

    J.X. Chen, G.Y. Cai, X.M. Chen, H. Liu, X. Chen, Y.M. Peng, F.Y. Liu, Z. Li and S.Z. Shi

To explore the role of metalloproteinase-1 (TIMP-1) tissue inhibitor in the mechanisms of kidney aging, we observed the effects of sense and antisense transfection of TIMP-1 and of metalloproteinase (MMP) inhibitors on phosphatase and tensin homolog (PTEN), vascular endothelial growth factor (VEGF), and Flk-1 expression in TIMP-1 transgenic human proximal tubular epithelial cells (HKCs). Transf.. Read More»

Genet. Mol. Res. 14(4): 2015.December.21.6

DOI: 10.4238/2015.December.21.6

Animal Genetics   Research Article

Genetic diversity and variability in populations of the white wax insect Ericerus pela, assessed by AFLP analysis

    H. Chen, R. He, Z.L. Wang, S.Y. Wang, Y. Chen, Z.C. Zhu and X.M. Chen1

The white wax insect Ericerus pela Chavannes (Hemiptera: Coccoidea) is an economically valuable insect species that has been used for over a thousand years in China. The present study focuses on assessing the genetic variability in different populations of E. pela collected from seven Chinese provinces. The amplified fragment length polymorphism technique was used to generate DNA fingerprints o.. Read More»

Genet. Mol. Res. 14(4): 2015.December.22.6

DOI: 10.4238/2015.December.22.6

Human Genetics   Research Article

Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease

    J.Y. Zhong, X.W. Zheng, H.D. Ye, H.B. Cui, W.P. Du, Z.X. Zhang, X.H. Fei, S.Y. Lin, J. Wang, J. Su, X.M. Chen and S.W. Duan

APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association st.. Read More»

Genet. Mol. Res. 14(4): 2015.October.2.8

DOI: 10.4238/2015.October.2.8

Human Genetics   Research Article

Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells

    M. Li, X.M. Chen, D.M. Wang, L. Gan and Y. Qiao

The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR-26a mimic, antagomir-26a, or control mimic. The Beclin 1 mRNA and protein levels were detected by quantitative polymerase chain reaction and western blot, respectively. The activity of Beclin 1 .. Read More»

Genet. Mol. Res. 15(2): gmr.15028193

DOI: 10.4238/gmr.15028193

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