V.E.P. Vicentini
Chemotherapeutical effects of the herbal medicine Uncaria tomentosa (Willd.) DC.
The use of medicinal plants dates back to the beginning of humanity, and today their application as complementary therapy has been widely disseminated as an alternative to conventional therapy. The medicinal plant named Uncaria tomentosa (Willd.) DC. (known as cat’s claw) is a common woody vine of the Amazon forest that has traditionally been used in the treat.. Read More»
Genet. Mol. Res. 16(3): gmr16039782
DOI: 10.4238/gmr16039782
Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems
Fluoxetine, commonly known as Prozac, is the first representative of the so-called new generation of antidepressants that promise efficacy, with few side effects, against deep depression, nervous bulimia, and anxiety. As there is a growing number of people suffering from anxiety and depression; consequently, the use of fluoxetine is also increasing. Verifying absenc.. Read More»
Genet. Mol. Res. 13(1): 2014.January.28.3
DOI: 10.4238/2014.January.28.3
In vivo antimutagenic effects of the Barbados cherry fruit (Malpighia glabra Linnaeus) in a chromosomal aberration assay
Barbados cherry (BC) (Malpighia glabra Linnaeus) is a functional fruit that is consumed to prevent disease. It is used as an adjuvant in the treatment of several diseases, and acts as an antianemic, an appetite stimulant, a wound healer, an anti-inflammatory, a mineralizer, an antifungal, and an antioxidant agent. Several chemotherapeutic agents, such as cyclophosph.. Read More»
Genet. Mol. Res. 15(4): gmr15049036
DOI: 10.4238/gmr15049036
Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro
The radioisotope iodine-131 [131I] can damage DNA. One way to prevent this is to increase the amount of antioxidants via dietary consumption. The goal of this study was to evaluate the radioprotective effect of fresh acerola pulp and synthetic beta-carotene in Rattus norvegicus hepatoma cells (HTC) in response to [131I] exposure in vitro. Cellular DNA damage was subsequently assessed using a cy.. Read More»
Genet. Mol. Res. 12(4): 2013.December.10.1
DOI: 10.4238/2013.December.10.1
Different responses of vanillic acid, a phenolic compound, in HTC cells: cytotoxicity, antiproliferative activity, and protection from DNA-induced damage
The consumption of healthy and natural foods has increased over the last few years, primarily because these foods are rich in substances with biological properties of interest, such as exerting anticancer effects and decreasing oxidative stress in living tissues. These foods support adequate nutrition, maintain health, and improve quality of life. Vanillic acid (VA).. Read More»
Genet. Mol. Res. 15(4): gmr15049388
DOI: 10.4238/gmr15049388
Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats
Radioactive iodine-131 (131I) is used in the treatment and diagnosis of thyroid gland injuries. However, because it emits ionizing radiation, it causes harmful effects to cells. Given that beta-carotene (BC) has antioxidant and antigenotoxic properties, this study aimed to investigate its radioprotective and antimutagenic activity in relation to 131I at the dose tha.. Read More»
Genet. Mol. Res. 13(1): 2014.March.31.5
DOI: 10.4238/2014.March.31.5
Influence of processing and storage of integral grape juice (Vitis labrusca L.) on its physical and chemical characteristics, cytotoxicity, and mutagenicity in vitro
Integral grape juice is extracted from the grape through processes that allow the retention of their natural composition. However, due to the severity of some processes, fruit juices can undergo changes in their quality. The present study evaluated the cytotoxic and mutagenic effects of integral grape juice by a cytokinesis-blocked micronucleus assay in Rattus norve.. Read More»
Genet. Mol. Res. 16(2): gmr16029670
DOI: 10.4238/gmr16029670
In vivo antimutagenic activity of the medicinal plants Pfaffia glomerata (Brazilian ginseng) and Ginkgo biloba
Complementary and alternative therapies, including the use of medicinal plants, have become almost standard among the world’s population. Pfaffia glomerata (PG), popularly known as Brazilian ginseng, is widely used as a restorer of vital functions, increasing mental balance, and is used for the treatment of diabetes and rheumatism. Ginkgo biloba (GB) is one of.. Read More»
Genet. Mol. Res. 16(3): gmr16039785
DOI: 10.4238/gmr16039785
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