R. Tungtrongchitr

Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand

• A. Tungtrongchitr
• J. Jumpasri
• N. Sookrung
• N. Visitsunthorn
• P. Tantilipikorn
• O. Piboonpocanan
• N. Indrawattana
• R. Tungtrongchitr
• W. Chaicumpa

Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled study aimed to identify the possible relat.. Read More»

Genet. Mol. Res. 16(3): gmr16039641

DOI: 10.4238/gmr16039641

Association of T869C gene polymorphism of transforming growth factor-β1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women

D. Utennam, A. Tungtrongchitr, B. Phonrat, R. Tungtrongchitr and S. Preutthipan

Osteoporosis is the most common metabolic bone disease; it is an important health problem among postmenopausal women. We evaluated the association of three polymorphisms, T869C, C-509T and G915C, of the TGF-β1 gene with bone mineral density (BMD) serum TGF-β1 levels in 278 postmenopausal female osteopenia/osteoporosis subjects and 95 postmenopausal female .. Read More»

Genet. Mol. Res. 11(1): http://dx.doi.org/2012.January.13.2

DOI: http://dx.doi.org/10.4238/2012.January.13.2

BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males

K. Suriyaprom1, R. Tungtrongchitr2, K. Thawnashom1 and Y. Pimainog1

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met B.. Read More»

Genet. Mol. Res. 12(4): 2013.October.24.3

DOI: 10.4238/2013.October.24.3

Association between rs155971 in the PCSK1 gene and the lipid profile of obese Thai children: a family-based study

S. Kulanuwat, J. Santiprabhob, B. Phonrat, C. Limwongse, A. Tungtrongchitr, N. Chongviriyaphan and R. Tungtrongchitr

Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 and rs6713532 in the POMC gene in a sample.. Read More»

Genet. Mol. Res. 14(3): 2015.August.7.23

DOI: 10.4238/2015.August.7.23

Association of HTTLPR and 5-HT2A T102C polymorphisms with smoking characteristics and anthropometric profiles of Thai males

K. Suriyaprom B. Phonrat U. Chuensumran A. Tungtrongchitr R. Tungtrongchitr

Nicotine increases serotonin release in the brain. Gene polymorphisms in the serotonergic system have been suggested to be associated with smoking behavior. We investigated a possible association between two polymorphisms in the serotonergic system - HTTLPR of a serotonin transporter gene and 5-HT2Aat position T102C - with biochemical and anthropometric parameters, and with cigarette smoking in.. Read More»

Genet. Mol. Res. 11(4): 2012.October.15.2

DOI: 10.4238/2012.October.15.2

Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study

S. Wannaiampikul, B. Phonrat, A. Tungtrongchitr, C. Limwongse, N. Chongviriyaphan, J. Santiprabhob and R. Tungtrongchitr

MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) play important roles in energy homeostasis. Severe early-onset obesity, known as monogenic obesity when it is the consequence of a mutation in a single-gene product, may result when energy homeostasis is disrupted. The purpose of our study was to screen for variations of the MC3R and MC4R genes and observe the mode of inheritance.. Read More»

Genet. Mol. Res. 14(4): 2015.December.22.35

DOI: 10.4238/2015.December.22.35

Exome sequencing in Thai patients with familial obesity

S. Kaewsutthi, J. Santiprabhob, B. Phonrat, A. Tungtrongchitr,P. Lertrit and R. Tungtrongchitr

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association.. Read More»

Genet. Mol. Res. 15(2):