The present study was intended to investigate the role of MTHFR gene functional polymorphisms, rs1801133 (C677T) and rs1801131 (A1298C) in the susceptibility and severity of Recurrent Pregnancy Losses (RPLs) in women with low socio-economic status among Asian Indians. We screened a total of 221 women that includes 102 RPL patients and 119 healthy controls. Following DNA isolat.. Read More»
Genet. Mol. Res. 18(3):
Preeclampsia (PE), a pregnancy specific vascular disorder which is characterized by hypertension and proteinuria is a leading cause of maternal, fetal/neonatal morbidity and mortality affecting 5-14% of pregnancies. PE is a multifactorial disorder associated with poor placentation, placental hypoxia, poor angiogenesis and excessive maternal inflammation. Adrenomedullin (ADM) is a multi.. Read More»
Genet. Mol. Res. 18(2):
Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE; suggests patient’s genotype .. Read More»
Genet. Mol. Res. 18(2):