J. Santos
Genetic diversity of Bacillus sp producers of amylase isolated from the soil
The microorganisms are the best source of extracellular enzymes since they allow an economical technology with low-resource consumption compared to animals and plants. The amylases are among the most important enzymes being the genus Bacillus one of the most investigated due to its ability to produce this enzyme. The objective of this study was to isolate and analyz.. Read More»
Genet. Mol. Res. 16(3): gmr16039771
DOI: 10.4238/gmr16039771
Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors
The cancer is one of the most common and severe problems in clinical medicine, and nervous system tumors represent about 2% of the types of cancer. The central role of the nervous system in the maintenance of vital activities and the functional consequences of the loss of neurons can explain how severe brain cancers are. The cell cycle is a highly complex process, w.. Read More»
Genet. Mol. Res. 7(2): vol7-2gmr445
DOI: 10.4238/vol7-2gmr445
New microsatellite markers for bananas (Musa spp)
Thirty-four microsatellite markers (SSRs) were identified in EST and BAC clones from Musa acuminata burmannicoides var. Calcutta 4 and validated in 22 Musa genotypes from the Banana Germplasm Bank of Embrapa-CNPMF, which includes wild and improved diploids. The number of alleles per locus ranged from 2 to 14. The markers were considered highly informative based on t.. Read More»
Genet. Mol. Res. 11(2): 2012.April.27.8
DOI: 10.4238/2012.April.27.8
Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas
The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an important role in maintaining genome integrity, although it is known that double-strand breaks are the main inducers of chromosomal aberrations. Cha.. Read More»
Genet. Mol. Res. 11(1): 2012.February.10.4
DOI: 10.4238/2012.February.10.4
Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determin.. Read More»
Genet. Mol. Res. 8(1): vol8-1gmr518
DOI: 10.4238/vol8-1gmr518
Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil
The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways. A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associated with susceptibility to human cancers... Read More»
Genet. Mol. Res. 7(1): vol7-1gmr415
DOI: 10.4238/vol7-1gmr415
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas
XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of sensitivity to radiation, they have been f.. Read More»
Genet. Mol. Res. 10(2): vol10-2gmr1125
DOI: 10.4238/vol10-2gmr1125
Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma
Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar functions. Like p53, p73 can bind to DNA and act.. Read More»
Genet. Mol. Res. 8(4): vol8-4gmr631
DOI: 10.4238/vol8-4gmr631
GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas
Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of developing some types of tumors. We exa.. Read More»
Genet. Mol. Res. 9(4): vol9-4gmr971
DOI: 10.4238/vol9-4gmr971
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