Animal Genetics
Development and evaluation of a loop-mediated isothermal amplification assay for detection of Ehrlichia canis DNA in naturally infected dogs using the p30 gene
Authors: V.C. Pinhanelli, P.N.M. Costa, G. Silva, D.M. Aguiar, C.M.L. Silva, A.L. Fachin and M. Marins
Canine monocytic ehrlichiosis (CME) is a common tick-borne disease caused by the rickettsial bacterium Ehrlichia canis (Rickettsiales: Anaplasmataceae). In view of the different stages and variable clinical signs of CME, which can overlap with those of other infections, a conclusive diagnosis can more readily be obtained by combining clinical and hematolo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.13
- DOI:
- 10.4238/2015.December.22.13
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
Bortezomib-based treatment of acute antibody-mediated rejection: a case report
Authors: Q. Wang, X.L. Li, X.G. Xu, B.Y. Shi, Z.M. Zhang, Z.L. Li, Y. Han, W.Q. Zhou, C.Q. Chen, M. Cai and X. Zhang
Antibody-mediated rejection (AMR) is an important factor affecting survival after renal transplantation. A highly selective proteasome inhibitor, bortezomib, clears activated plasma cells from the body and has important therapeutic effect on AMR. We investigated the effects of bortezomib on AMR in a patient after a second renal transplant. Biopsy confirme.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.20
- DOI:
- 10.4238/2015.December.22.20
Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement
Authors: X.X. Wei, J.P. Chu, Y.Z. Zou, N. Ru, S.X. Cui and Y.X. Bai
The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.23
- DOI:
- 10.4238/2015.December.22.23
Protective efficacy of a genetic subunit bacterin against edema disease of swine in mice
Authors: X.L. Yang, Y.J. Liu, L.Q. Hu, L.W. Guo, G.P. Liu, B. Wu and H.C. Chen
The exotoxin SLT-IIeB from the Escherichia coli Ee strain was expressed in E. coli, and the recombinant protein was purified, mixed with the Ee strain, then emulsified with oil-emulsion adjuvants to obtain a mixed subunit bacterin. Groups of Kunming mice were immunized at weeks 0 and 2, and challenged intraperitoneally with the Ee strain at week 4. Antibo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.29
- DOI:
- 10.4238/2015.December.22.29
Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling
Authors: Q. Song, Y.L. Ma, J.Q. Song, Q. Chen, G.S. Xia, J.Y. Ma, F. Feng, X.J. Fei and Q.M. Wang
Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure ox.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.32
- DOI:
- 10.4238/2015.December.22.32
Genetic diversity and variability in populations of the white wax insect Ericerus pela, assessed by AFLP analysis
Authors: H. Chen, R. He, Z.L. Wang, S.Y. Wang, Y. Chen, Z.C. Zhu and X.M. Chen1
The white wax insect Ericerus pela Chavannes (Hemiptera: Coccoidea) is an economically valuable insect species that has been used for over a thousand years in China. The present study focuses on assessing the genetic variability in different populations of E. pela collected from seven Chinese provinces. The amplified fragment length polymorphism technique.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.6
- DOI:
- 10.4238/2015.December.22.6
Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)
Authors: Y.X. Fan, R.B. Wu, X. Qiao, Y.J. Zhang, R.J. Wang, R. Su, J.H. Wu, Y. Dong and J.Q. Li
Previous molecular genetic studies of the goat hair life cycle have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in hair follicle cycle regulation, Illumina sequencing technology was used to catalog differential gene expression profiles in the hair growth cycle (anagen to catagen) .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.15
- DOI:
- 10.4238/2015.December.22.15
Phylogenetic relationships of leaf monkeys (Presbytis; Colobinae) based on cytochrome b and 12S rRNA genes
Authors: V.F. Vun, M.C. Mahani, M. Lakim, A. Ampeng and B.M. Md-Zain
Little is known about the classification and phylogenetic relationships of the leaf monkeys (Presbytis). We analyzed mitochondrial DNA sequences of cytochrome b (Cyt b) and 12S rRNA to determine the phylogenetic relationships of the genus Presbytis. Gene fragments of 388 and 371 bp of Cyt b and 12S rRNA, respectively, were seq.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1048
- DOI:
- 10.4238/vol10-1gmr1048
Biological and molecular characterization of silkworm strains from the Brazilian germplasm bank of Bombyx mori
Authors: N.C. Pereira, R.E.F. Munhoz, T.S. Bignotto, R. Bespalhuk, L.B. Garay, C.R.N. Saez, V.A. Fassina, A. Nembri and M.A. Fernandez
Brazil has only one public genetic pool of Bombyx mori strains, which was established in 2005 at Universidade Estadual de Maringá, Maringá, Paraná State. This genetic bank has been maintained, and the strains have been characterized using genetic and morphological tools. The quantitative and qualitative traits, directly or indirectly .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.28.1
- DOI:
- 10.4238/2013.June.28.1