Animal Genetics
Effect of compound Maqin decoction on TGF-�²1/Smad proteins and IL-10 and IL-17 content in lung tissue of asthmatic rats
Authors: Y.H. Xie, X.P. Li, Z.X. Xu, P. Qian, X.L. Li and Y.Q. Wang
In this research, compound Maqin decoction (CMD) has been shown to positively affect in airway inflammation of asthma models. We evaluated the effects of CMD on the expression of transforming growth factor (TGF)-β1/Smad proteins, interleukin (IL)-17, and IL-10 in lung tissue of asthmatic rats. Asthma was induced in a rat .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037539
- DOI:
- 10.4238/gmr.15037539
Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models
Authors: J.Y. Wang, Z.H. Li, M. Ye, Q. Feng, Z.M. Chen, X.S. Ye, Z.G. Wu, B. Wang, L. Liu and J. Yao
Biliary atresia (BA) is a destructive bile duct disease occurring in newborn children within a few weeks after birth. In this study, the effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition (EMT) in experimental BA was explored by constructing BA mouse models via Rhesus rotavirus vaccine infection. miR-29c and.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037753
- DOI:
- 10.4238/gmr.15037753
Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle
Authors: N. HernÃ?¡ndez, J.C. MartÃ?Ânez-GonzÃ?¡lez, G.M. Parra-Bracamonte, A.M. Sifuentes-RincÃ?³n, N. LÃ?³pez-Villalobos, S.T. Morris, F. Briones-Encinia, E. Ortega-Rivas, V.I. Pacheco-Contreras and L.A. Meza-GarcÃ?Âa
Polymorphisms in candidate genes can produce significant and favorable changes in the phenotype, and therefore are useful for the identification of the best combination of favorable variantsfor marker-assisted selection. In the present study, an assessment to evaluate the effect of 11 single nucleotide polymorphisms (SNPs) in .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038449
- DOI:
- 10.4238/gmr.15038449
Effects of DNA methyltransferase inhibitor RG108 on methylation in buffalo adult fibroblasts and subsequent embryonic development following somatic cell nuclear transfer
Authors: H.L. Sun, L.N. Meng, X. Zhao, J.R. Jiang, Q.Y. Liu, D.S. Shi and F.H. Lu
Buffalo are characteristic livestock of the Guangxi Zhuang Autonomous Region of China, but their low reproductive capacity necessitates the use of somatic cell nuclear transfer (SCNT). We investigated the effects of RG108 on DNA methylation in buffalo adult fibroblasts, and on subsequent SCNT embryo development. RG108 treatmen.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038455
- DOI:
- 10.4238/gmr.15038455
Effects of thrombin on the secondary cerebral injury of perihematomal tissues of rats after intracerebral hemorrhage
Authors: C.M. Liu, B.Z. Shi and J.S. Zhou
This study aimed to investigate the effects of thrombin released in hematoma after intracerebral hemorrhage (ICH) on the cerebral injury of perihematomal tissues and to evaluate the protection effect of hirudin on the cerebral injury after ICH. We used the autologous uncoagulated blood injection method to prepare the ICH rat model, and all rats were rando.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.4
- DOI:
- 10.4238/2014.June.18.4
Polymorphic microsatellite markers for the endangered fish, the slender shiner Pseudopungtungia tenuicorpa and cross-species amplification across five related species
Authors: K.S. Ki, S.J. Moo, S.H. Han2, K.Y. Kim and I.C. Bang
The slender shiner Pseudopungtungia tenuicorpa (Cypriniformes; Cyprinidae; Gobioninae) is an endangered freshwater fish species endemic to Korea. The current strategies for its conservation involve the study of population genetic characters and identification of management units. These strategies require suitable molecular mar.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038496
- DOI:
- 10.4238/gmr.15038496
Protective role of neuregulin-1 toward doxorubicin-induced myocardial toxicity
Authors: Y.Q. Liu, M. Yang, C.H. Duan, G.B. Su, J.H. Wang, Y.F. Liu and J. Zhang
The aim of this study was to investigate the role of the rat neuregulin-1 (NRG-1) protein in reducing doxorubicin (DOX)-induced myocardial toxicity and its underlying mechanism. The prokaryotic expression of the NRG-1 protein and the CCK8-determined activity of rat primary myocardial cells were evaluated under different DOX co.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.June.18.5
- DOI:
- 10.4238/2014.June.18.5
Identification and characterization of SREBF2 expression and its association with chicken carcass traits
Authors: F. Ye, M.H. Qiu, H.Y. Xu, X. Lan, Q. Zhu, X.L. Zhao, H.D. Yin, Y.P. Liu and Y. Wang
The sterol regulatory element-binding transcription factor 2 gene (SREBF2) plays an important role in regulating lipid homeostasis. To reveal the genetic factors that underlie carcass fat deposition in chickens, we cloned the coding DNA sequence of chicken SREBF2, investigated SREBF2 mRNA expression levels in various tissues, .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038514
- DOI:
- 10.4238/gmr.15038514
Improved gastric emptying in diabetic rats by irbesartan via decreased serum leptin and ameliorated gastric microcirculation
Authors: L. He, Y. Sun, Y. Zhu, R. Ren, Y. Zhang and F. Wang
Diabetic gastroparesis (DG) is a common clinical complication of diabetes mellitus. Leptin may cause delayed gastric emptying in the central and peripheral pathways. Microcirculatory disturbances in the stomach make gastric smooth muscles and nerves hypoxic-ischemic, thereby impairing gastric motility. Irbesartan is an angiote.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.2
- DOI:
- 10.4238/2014.September.5.2
Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice
Authors: Y. Wang, Y.D. Zhu, Q. Gui, X.D. Wang and Y.X. Zhu
In this study, we examined the effect glucagon-induced hyperglycemia on tumor growth as well as the role of the hypoxia-inducible factor 1 (HIF-1)-vascular endothelial growth factor (VEGF) pathway in this condition. A high concentration of glucose (HG) was utilized to treat HeLa cells under hypoxic or normoxic conditions, and .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.3
- DOI:
- 10.4238/2014.September.5.3