Animal Genetics
EZH2 suppresses hepatocellular differentiation of mouse bone marrow mesenchymal stem cells
Authors: T. Lu, H. Sun, J. Lv, M.F. Yang, F. Zhang, Y. Qian, and X.J. Dong
Our previous studies have indicated that mouse bone marrow mesenchymal stem cells (mBMMSCs) have potential to differentiate into hepatocytes with high efficiency. Our study aimed to evaluate the role of the mouse histone methyltransferase enhancer of zeste homolog 2 gene (EZH2) in the hepatocellular differentiation of mBMMSCs... Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.3
- DOI:
- 10.4238/2014.March.31.3
MRJP microsatellite markers in Africanized Apis mellifera colonies selected on the basis of royal jelly production
Authors: R.S. Parpinelli, M.C.C. Ruvolo-Takasusuki and V.A.A. Toledo
It is important to select the best honeybees that produce royal jelly to identify important molecular markers, such as major royal jelly proteins (MRJPs), and hence contribute to the development of new breeding strategies to improve the production of this substance. Therefore, this study focused on evaluating the genetic varia.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.16
- DOI:
- 10.4238/2014.August.28.16
Interactions between rare-earth ions and DNA of Bashibai sheep
Authors: J. Aniwashi, H.A. Kaleri, Y. Sulaiman, L. Qi-fa and X. Zhuang
The interaction between rare-earth ions and DNA from Bashibai sheep was studied by microcalorimetry and electrochemistry. The DNA chain was found to have four to five binding sites for rare-earth ions. The binding affinity was about 10-5-10-6 M. It was also found that smaller ions caused more heat to be released in the process.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1070
- DOI:
- 10.4238/vol10-2gmr1070
Distribution of H-FABP and ACSL4 gene polymorphisms and their associations with intramuscular fat content and backfat thickness in different pig populations
Authors: J.N. Chen, Y.Z. Jiang, W.M. Cen, S.H. Xing, L. Zhu, G.Q. Tang, M.Z. Li, A.A. Jiang, P.E. Lou, A.X. Wen, Q. Wang, T. He, G.X. Zhu, M. Xie and X.W. Li
Here, we analyzed the distribution of H-FABP/(HinfI, MspI, and HaeIII) and ACSL4/RsaI polymorphisms, and the associations of these 4 polymorphic loci with intramuscular fat (IMF) content and backfat thickness (BFT) in Yanan, Jinhua, Duroc, Landrace, Yorkshire, and Duroc x (Landrace x Yorkshi.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.20
- DOI:
- 10.4238/2014.August.28.20
Antimutagenic and radioprotective activities of beta-carotene against the biological effects of iodine-131 radiopharmaceutical in Wistar rats
Authors: A.P. Berti, E. D�¼sman, R.G. Mariucci, N.B. Lopes and V.E.P. Vicentini
Radioactive iodine-131 (131I) is used in the treatment and diagnosis of thyroid gland injuries. However, because it emits ionizing radiation, it causes harmful effects to cells. Given that beta-carotene (BC) has antioxidant and antigenotoxic properties, this study aimed to investigate its radioprotective and antimutagenic acti.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.5
- DOI:
- 10.4238/2014.March.31.5
Inhibitory effect of dexamethasone on Lewis mice lung cancer cells
Authors: Y. Geng, J. Wang, H. Jing, H.W. Wang and Y.X. Bao
Recent studies have found that glucocorticoids are closely associated with oncogenesis and the development of many types of tumors. The aim of this study was to observe the effect of dexamethasone on the growth and angiogenesis of transplanted Lewis lung carcinoma in mice. Lewis lung carcinoma cells were inoculated subcutaneou.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.4
- DOI:
- 10.4238/2014.August.29.4
mRNA expression profiles of heat shock proteins of wild and salinity-tolerant swimming crabs, Portunus trituberculatus, subjected to low salinity stress
Authors: X.N. Bao, C.K. Mu, C. Zhang, Y.F. Wang, W.W. Song, R.H. Li and C.L. Wang
Challenged by the low salinity, 4 parts per thousand (4 ppt), for 72h, the survivals of swimming crabs (Portunus trituberculatus) were collected as the screened group (SG, tolerant to low salinity). Aiming at identifying the mechanism of low salinity tolerance, quantitative real-time PCR was employed to investigate the express.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.5
- DOI:
- 10.4238/2014.August.29.5
Molecular phylogenetic and dating analysis of pierid butterfly species using complete mitochondrial genomes
Authors: Y. Cao, J.S. Hao, X.Y. Sun, B. Zheng and Q. Yang
Pieridae is a butterfly family whose evolutionary history is poorly understood. Due to the difficulties in identifying morphological synapomorphies within the group and the scarcity of the fossil records, only a few studies on higher phylogeny of Pieridae have been reported to date. In this study, we describe the complete mito.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049196
- DOI:
- 10.4238/gmr15049196
Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models
Authors: C. Wang, J. Wang, D. Jia, L. Li, B. Jia, S. Fan, J. Song, X. Hu, Y. Wang and D. Wang
Paecilomyces hepiali (PH), a well-known medicinal fungus, has various pharmacological efficacies. In our study, the antinociceptive effects of PH and underlying mechanisms were evaluated using various mouse models. An acetic acid-induced writhing test, hot plate test, and formalin test were employed to evaluate the antinociceptive activities of PH. The le.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038996
- DOI:
- 10.4238/gmr.15038996
Molecular analysis of cytosolic and mitochondrial malate dehydrogenases isolated from domestic cats (Felis catus)
Authors: N. Sasaki, M. Nakamura and S. Soeta
Malate dehydrogenase (MDH) plays crucial roles in energy and cellular metabolism. In this study, we describe the identification and characterization of cytosolic MDH (MDH1) and mitochondrial MDH (MDH2) in liver of domestic cat (Felis catus). To clone the feline full-length MDH genes, we performed rapid amplification of cDNA ends. The MDH1 gene en.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.7
- DOI:
- 10.4238/2014.August.29.7