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Medical Genetics   Research Article

Expression of HCN and sodium channels in murine model of Type I diabetes

Authors: Anantha Maharasi Rama Krishnan and Kavitha Sankaranarayanan

Pancreatic apoptosis is an important event in the pathogenesis of Type 1 Diabetes. It is characterized by secretion and binding of inflammatory cytokines to the pancreatic islets, that activate downstream signaling mechanism. These signaling mechanisms finally increase intracellular calcium level and that lead to the activation of apoptotic pathways. Ion .. Read More»

Genet. Mol. Res. 18(2):
Human Genetics   Research Article

Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes

Authors: Y. Al-Lahham, A.K.B. Mendes, E.M. Souza, D. Alberton, F.G.M. Rego, G. Valdameri and G. Picheth

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transp.. Read More»

Genet. Mol. Res. 16(3):
gmr16039755
DOI:
10.4238/gmr16039755
Medical Genetics   Research Article

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Authors: J.S. Xi, C.L. Nie, J. Wang, Y. Ma and A.H. Ma

Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-.. Read More»

Genet. Mol. Res. 14(4):
2015.November.25.13
DOI:
10.4238/2015.November.25.13
Human Genetics   Research Article

Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents

Authors: H.W. Liu, R.Y. Xu, R.P. Sun, Q. Wang, J.L. Liu, W. Ge1and Z. Yu

Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 he.. Read More»

Genet. Mol. Res. 14(1):
2015.January.15.8
DOI:
10.4238/2015.January.15.8
Human Genetics   Research Article

Bioinformatic analysis of endothelial progenitor cells exposed to folic acid in type 1 diabetes mellitus

Authors: D.N. Fang, X.D. He, X.H. Li, H. Jia, P.Y. Li, Q. Lu, Z. Quan and Q.L. Wang

We investigated the effects of type 1 diabetes mellitus (T1DM) on endothelial progenitor cells (EPCs) at the molecular level and assessed the therapeutic potential of folic acid (FA) in DM. We downloaded the gene expression profile of the EPCs from T1DM patients before and after treatment with FA and from healthy controls. We .. Read More»

Genet. Mol. Res. 13(1):
2014.January.3.1
DOI:
10.4238/2014.January.3.1
Human Genetics   Research Article

Association of IL-1α gene polymorphism with susceptibility to type 1 diabetes in Chinese children

Authors: X. Zhou, J.G. Ca, H. Peng, J.L. Wang and G.M. Li

The interleukin-1α (IL-1α) gene appears to play a role in the pathogenesis of type 1 diabetes (T1D). Therefore, the aim of this study was to investigate the contribution of the IL-1 rs1800587 gene polymorphism to susceptibility to T1D in Chinese children. This case-control study included 332 Chinese children with T1D and 332 healthy controls. .. Read More»

Genet. Mol. Res. 15(3):
gmr.15038025
DOI:
10.4238/gmr.15038025
Medical Genetics   Research Article

All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model

Authors: Y. Wang, Y.J. Zhong, Y.Y. Wang, J. Xing and Z.M. Wang

The aim of this study was to explore the molecular mechanism by which all-trans retinoic acid (ATRA) prevents type 1 diabetes mellitus (T1DM). Fifty ICR mice were randomly assigned to three groups: prevention group [N = 20; mice received 10 mg/kg ATRA daily for 5 days and then 60 mg/kg streptozotocin (STZ) for 5 days]; diabeti.. Read More»

Genet. Mol. Res. 15(1):
gmr.15017522
DOI:
10.4238/gmr.15017522
Medical Genetics   Research Article

Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III

Authors: J. de Azevêdo Silva, N.A.C. Tavares, M.M.S. Santos, R. Moura, R.L. Guimarães, J. Araújo, S. Crovella and L.A.C. Brandão

Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing β cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs simultaneously with autoimmune polyglandular syndrome type III (AP.. Read More»

Genet. Mol. Res. 14(4):
2015.December.21.46
DOI:
10.4238/2015.December.21.46
Human Genetics   Research Article

Association of TNF-α, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil

Authors: N.A.C. Tavares, M.M.S. Santos, R. Moura, J. Araújo, R.L. Guimarães, S. Crovella and L.A.C. Brandão

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polygland.. Read More»

Genet. Mol. Res. 14(4):
2015.December.28.42
DOI:
10.4238/2015.December.28.42