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Changes in cyclic GMP level and phosphodiesterase activity during follicular development in the rat ovary
Authors: C.Q. Fu, F.X. Shi, Z.H. Zhang, J.R. Li, X.H. Huang and Z.C. Wang
Guanosine 3',5'-cyclic monophosphate (cGMP), as a second messenger, plays potential roles in ovarian functions. To elucidate the role of phosphodiesterase (PDE) in cGMP signaling during ovarian follicular development, the present study was conducted to investigate ovarian cGMP level and cGMP-PDE activity by radioimmunoassay (R.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.7
- DOI:
- 10.4238/2014.August.7.7
Variation and genetic structure of Tunisian Festuca arundinacea populations based on inter-simple sequence repeat pattern
Authors: N. Chtourou-Ghorbel, H. Elazreg, S. Ghariani, N. Ben Mheni, M. Sekmani, M. Chakroun and N. Trifi-Farah
Tunisian tall fescue (Festuca arundinacea Schreb.) is an important grass for forages or soil conservation, particularly in marginal sites. Inter-simple sequence repeats were used to estimate genetic diversity within and among 8 natural populations and 1 cultivar from Northern Tunisia. A total of 181 polymorphic inter-simple sequence repeat markers were ge.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.17
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.17
Construction and partial characterization of a Corynebacterium pseudotuberculosis bacterial artificial chromosome library through genomic survey sequencing
Authors: F.A. Dorella, M.S. Fachin, A. Billault, E. Dias Neto, C. Soravito, S.C. Oliveira, R. Meyer, A. Miyoshi and V. Azevedo
Corynebacterium pseudotuberculosis is a gram-positive bacterium that causes caseous lymphadenitis in sheep and goats. However, despite the economic losses caused by caseous lymphadenitis, there is little information about the molecular mechanisms of pathogenesis of this bacterium. Genomic libraries constructed in bacterial art.. Read More»
- Genet. Mol. Res. 5(4):
Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance
Authors: Gumux-Akay G, Unal AE, Bayar S, Karadayi K, Elhan AH, Sunguroqlu A and Tukun A
Telomerase activity is responsible for telomere maintenance and is believed to be crucial in most immortal cells and cancer cells; however, its clinicopathological significance in gastric cancer remains to be clarified. The aim of the present study was to assess whether malignant progression of gastric adenocarcinoma correlate.. Read More»
- Genet. Mol. Res. 6(1):
Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells
Authors: J.Z. Mei, G.J. Liu, X.J. Zhang, J.Z. Zhao and R.T. Feng
We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and E.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.18
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.18
Cloning, sequencing, expression, and antigenic characterization of rMSP4 from Anaplasma marginale isolated from Paran�¡ State, Brazil
Authors: Kawasaki PM, Kano FS, Vidotto O and Vidotto MC
Anaplasmosis is a bovine intraerythrocytic disease caused by the bacterium Anaplasma marginale; it causes significant economic losses in tropical and subtropical regions, worldwide. The msp4 gene of an A. marginale strain isolated in Paraná, Brazil, was amplified by PCR and sequenced; its cloning into the pET102/D-TOPO&.. Read More»
- Genet. Mol. Res. 6(1):
Expression and clinical significance of obesity-associated gene STEAP4 in obese children
Authors: H.M. Xu, Y.Z. Cui, W.G. Wang, H.X. Cheng, Y.J. Sun, H.Y. Zhao and Y.Q. Yan
The aim of this study was to investigate the expression and clinical significance of the obesity-associated gene STEAP4 in obese children. Fifty-three obese children and 33 children with a standard body weight (control) from our hospital were recruited to this study. The expression of STEAP4 mRNA and protein in the adipose tis.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048705
- DOI:
- 10.4238/gmr.15048705
Selection of sorghum hybrids grown under aluminum saturation
Authors: C.B. Menezes, G.A. Carvalho Junior, L.A. Silva, K.C. Bernardino, J.V. Magalh�£es, C.T. Guimar�£es, L.J.M. Guimar�£es and R.E. Schaffert
The purpose of this study was to evaluate 165 hybrids derived from lines previously selected for aluminum (Al) tolerance. Nine check cultivars were used, eight commercial hybrids and one experimental hybrid. Hybrids were evaluated at three levels of Al saturation (0, 20 and 40% on average). The differences between the environm.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.12
- DOI:
- 10.4238/2014.August.7.12
Translocation breakpoints of chromosome 1 in male carriers: clinical features and implications for genetic counseling
Authors: R.X. Wang, H.G. Zhang, Y. Pan, S. Chen, F.G. Yue, D.L. Zhu and R.Z. Liu
Reciprocal translocation is closely associated with male infertility and recurrent miscarriages. Balanced reciprocal translocations associated with reproductive failures are predominantly observed on chromosome 1. Additionally, infertile male patients present a number of breakpoints throughout chromosome 1. A translocation bre.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048707
- DOI:
- 10.4238/gmr.15048707
Personalized diagnosis by cached solutions with hypertension as a study model
Authors: P.C. Carvalho, S.S. Freitas, A.B. Lima, M. Barros, I. Bittencourt, W. Degrave, I. Cordovil, R. Fonseca, M.G.C. Carvalho, R.S. Moura Neto and P.H. Cabello
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of .. Read More»
- Genet. Mol. Res. 5(4):