Renal Cell Carcinoma
Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues
Authors: H.B. Xia, H.W. Cui, L. Su, Z.H. Zhang, X.Y. Yang, S.Q. Ning and X.L. Su
We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using im.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039278
- DOI:
- 10.4238/gmr16039278
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746
Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients
Authors: Y.-Q. Yang and J. Chen
We conducted a study to investigate the possible role of the vascular endothelial growth factor (VEGF) polymorphisms -2578C/A, -1154G/A and -634C/G and clinical factors in renal cell carcinoma (RCC) prognosis in a cohort of 336 RCC cases. A total of 336 patients with RCC were recruited from PLA General Hospital between January.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.16
- DOI:
- 10.4238/2014.July.4.16
Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma
Authors: T.D. Han, D.H. Shang and Y. Tian
Tremendous efforts have been made in renal cell carcinoma (RCC) patients’ research; however, clinical findings in patients have been disappointing. The aims of our study were to identify better or alternative therapeutic methods that can reverse chemotherapy resistance and to enhance sensitivity to docetaxel (DOX)-based chemotherapy drugs. We evalua.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017321
- DOI:
- 10.4238/gmr.15017321
Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study
Authors: B.-L. Shen, Q.-S. Qu, S.-Z. Miao and Y.-X. Zhang
We conducted this case-control study to assess the role of the VEGF -2578C/A, +1612G/A, +936C/T and -634G/C gene polymorphisms in the development of renal cell carcinoma (RCC). A hospital-based case-control study was conducted in a 360 consecutive primary RCC patients and 360 age and gender-matched controls during January 2010 and January 2014. The polyme.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.22.5
- DOI:
- http://dx.doi.org/10.4238/2015.September.22.5
Predictive value of vascular endothelial growth factor polymorphisms on the risk of renal cell carcinomas
Authors: W. Xian, H. Zheng and W.J. Wu
We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymorphisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population included 266 RCC patients who were newly diagnosed and histologically confirmed to have RCC as well as 532 cancer-free.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.8
- DOI:
- 10.4238/2015.July.13.8
Abnormal gene expression profile reveals the common key signatures associated with clear cell renal cell carcinoma: a meta-analysis
Authors: H.J. Zhang, Z.Q. Sun, W.Q. Qian and L. Sheng
The aims of this study were to identify the common gene signatures of clear cell renal cell carcinoma (CCRCC), and to expand the respective protein-protein interaction networks associated with CCRCC regulation. For the latter, we utilized multiple gene expression data sets from the National Center for Biotechnology Information (NCBI) Gene Expression Omnib.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.7
- DOI:
- 10.4238/2015.March.27.7
Metastatic renal cell carcinoma to the left maxillary sinus
Authors: Y.-F. He, J. Chen, W.-Q. Xu, C.-S. Ji, J.-P. Du, H.-Q. Luo and B. Hu
Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.12
- DOI:
- 10.4238/2014.September.12.12
Network spatio-temporal analysis predicts disease stage-related genes and pathways in renal cell carcinoma
Authors: X.H. Li, C.Z. Yang and J. Wang
The purpose of this study was to screen the key genes and pathways of renal cell carcinoma (RCC) and lay the foundation for its diagnosis and therapy. Microarray data of normal subjects and RCC patients at different stages of disease were used to screen differentially expressed genes (DEGs). Based on the DEGs in the four disea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028061
- DOI:
- 10.4238/gmr.15028061
Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer
Authors: O.A. Uyar, M. Kara, D. Erol, A. Ardicoglu and H. Yuce
Increased oxidative stress can help promote carcinogenesis, including development of renal cell carcinoma. The enzyme protects low-density lipoproteins from oxidation and can be a factor in this process. PON1 Q192R and L55M paraoxonase gene polymorphisms were assessed in 60 renal cell carcinoma patients and 60 healthy controls.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr927
- DOI:
- 10.4238/vol10-1gmr927