Polymorphism
Prevalence of CYP2C8 polymorphisms in a North Indian population
Authors: S. Minhas, N. Setia, S. Pandita, R. Saxena, I.C. Verma and S. Aggarwal
CYP2C8 is an important member of the cytochrome P450 family of enzymes; it affects the activity of various drugs used in routine clinical practice, including amiodarone, chloroquine, amodiaquine, and repaglinide, as well as endogenous compounds, such as arachidonic acid and retonic acid. It is also the main enzyme involved in the metabolism of the widely .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.7
- DOI:
- 10.4238/2013.July.8.7
Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson�s disease in a Chinese population
Authors: C.C. Zhao, H.B. Cai, H. Wang and S.Y. Pan
In this study, we investigated the role of ADH2 Arg47His and ALDH2 Glu487Lys genetic polymorphisms in the development of Parkinson’s disease in a Chinese population. Between January 2013 and May 2014, 115 patients with Parkinson’s disease and 214 healthy controls were recruited in our study. Genotyping of ADH2 Arg4.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038606
- DOI:
- 10.4238/gmr.15038606
Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene
Authors: T.T. Han, J. Ran, X.P. Ding, L.J. Li, L.Y. Zhang, Y.P. Zhang, S.S. Nie and L. Chen
Chromosome abnormalities, Y-chromosome microdeletions, and androgen receptor gene CAG and GGN repeat polymorphisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-obstructive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seve.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.3
- DOI:
- 10.4238/2013.July.8.3
Lack of association between the interleukin 6 gene -174G>C polymorphism and colorectal cancer: evidence from a meta-analysis
Authors: J.J. Hu, Z.T. Wang and J. Zhong
Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studie.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.2
- DOI:
- 10.4238/2013.July.8.2
Tumor necrosis factor-�± and -�² genetic polymorphisms as a risk factor in Saudi patients with vitiligo
Authors: F. Al-Harthi, A. Zouman, M. Arfin, M. Tariq and A. Al-Asmari
Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical ro.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.1
- DOI:
- 10.4238/2013.July.8.1
Effects of polymorphisms in the bovine growth differentiation factor 9 gene on sperm quality in Holstein bulls
Authors: K.Q. Tang, W.C. Yang, X.X. Zhang and L.G. Yang
Members of the transforming growth factor-β (TGFβ) superfamily are critical regulators of germ cell development that act as extracellular ligands of the signal transduction pathways regulating proliferation, differentiation, apoptosis, and other aspects of cell behavior. Growth differentiation factor 9 (GDF9) is a member of the TGFβ superfa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.4.1
- DOI:
- 10.4238/2013.July.4.1
Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population
Authors: I.B. Han, A.E. Ropper, Y.D. Teng, D.A. Shin, Y.J. Jeon, H.M. Park, D.E. Shin, Y.S. Park, K.N. Kim and N.-K. Kim
Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.8.10
- DOI:
- 10.4238/2013.July.8.10
Association of growth factor receptor-bound protein 10 gene polymorphism with superovulation traits in Changbaishan black cattle
Authors: Y. Wu, Z. Zhang, J.B. Zhang4 and Q. Deng
The application of assisted reproductive technology in animal production benefits the economy and conservation of biological resources. Single nucleotide polymorphism (SNPs) was used as predictive markers for breeding and reproduction. In the present study, we examined the association between a SNP of the grb10 gene and supero.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049262
- DOI:
- 10.4238/gmr15049262
Effect of ARMS2 gene polymorphism on intravitreal ranibizumab treatment for neovascular age-related macular degeneration
Authors: H. Bardak, Y. Bardak, Y. Ercalik, E. Turkseven Kumral, S. Imamoglu, M. Gunay, H. Ozbas and O. Bagci
Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. The ARMS2 gene has been found to be associated with AMD. Currently, intravitreal ranibizumab (IVR) treatment is one of the widely used treatments for neovascular AMD. The aim of this study was to investigate the association between t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049164
- DOI:
- 10.4238/gmr15049164
The GSTP1 A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis
Authors: G.Z. Huang, W. Shan, L. Zeng and L.G. Huang
Studies investigating the association between the glutathione S-transferase P1 (GSTP1) A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia (ALL) report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China N.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.24.3
- DOI:
- 10.4238/2013.July.24.3