Polymorphism
Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey
Authors: M.B. Yilmaz, A. Pazarbasi, A.I. Guzel, S. Kocaturk-Sel, H. Kasap, M. Kasap, I.F. Urunsak, S. Basaran, D. Alptekin and O. Demirhan
Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two co.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1204
- DOI:
- 10.4238/vol10-3gmr1204
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil
Authors: J.M. Biselli, E.M. Goloni-Bertollo, B.L. Zampieri, R. Haddad, M.N. Eberlin and E.C. Pavarino-Bertelli
The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS). Seventy-two DS mothers and 194.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr388
- DOI:
- 10.4238/vol7-1gmr388
Characterization of chloroplast DNA microsatellites from Saccharum spp and related species
Authors: D.M. Melotto-Passarin, E.V. Tambarussi, K. Dressano, V.F. De Martin and H. Carrer
Microsatellites, or simple sequence repeats (SSRs), and their flanking regions in chloroplast genomes (plastomes) of some species of the family Poaceae were analyzed in silico to look for DNA sequence variations. Comparison of the complete chloroplast DNA sequences (cpDNAs) of sugarcane (Saccharum hybrid cv. SP-80-3280 and S. .. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1019
- DOI:
- 10.4238/vol10-3gmr1019
Schistosome/mollusk: genetic compatibility
Authors: A.L.D. Oliveira, D. Da Silva, E.M. Zanotti-Magalhaes,A.Z. Abdel-Hamid, J.T. Ribeiro-Paes
Schistosomiasis remains one of the most prevalent parasitic infections and has significant economic and public health consequences in many developing countries. Economic development and improvement in standard of living in these countries are dependent on the elimination of this odious disease. For the control of Schistosomias.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr444
- DOI:
- 10.4238/vol7-2gmr444
Isolation and characterization of tetranucleotide repeat polymorphic microsatellite loci in Larus saundersi (Aves, Laridae)
Authors: H.-X. Jiang, S.L. Ren, Y.-Q. Hou, M. Yang and X.-B. Wu
Nine polymorphic microsatellite loci were isolated, using tetranucleotide repeat oligonucleotide probes from an enriched DNA library of the globally “vulnerable” Saunders’s gull (Larus saundersi), collected from the Yancheng coastal wetland, one of the three remaining breeding sites in China. Six breast muscl.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1164
- DOI:
- 10.4238/vol10-3gmr1164
A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico
Authors: L. GarcÃ?Âa-Ortiz, G. Vargas-AlarcÃ?³n, J.M. Fragoso, J. Granados, L. Maldonado Noriega, A. Navas PÃ?©rez , E. Huerta Reyes, J.C. Zenteno-Ruiz and E. MartÃ?Ânez-Cordero
The human orosomucoid 1 gene (ORM1) codes an alpha-1-acid glycoprotein that has been classified as an acute-phase reactive protein, and a major drug-binding serum component, as well as an immunomodulatory protein with genetic polymorphisms. Evaluation of ORM variation through isoelectric focusing and immunobloting has revealed a world-wide distribution of.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr348
- DOI:
- 10.4238/vol7-1gmr348
Investigation of the association of two candidate genes (H-FABP and PSMC1) with growth and carcass traits in Qinchuan beef cattle from China
Authors: W. Liang, H.L. Zhang, Y. Liu, B.C. Lu, X. Liu, Q. Li and Y. Cao
Growth and carcass traits are economically important quality characteristics of beef cattle and are complex quantitative traits that are controlled by multiple genes. In this study, 2 candidate genes, H-FABP (encoding the heart fatty acid-binding protein) and PSMC1 (encoding the proteasome 26S subunit of ATPase 1) were investi.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.15
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.15
Comparative genetic analysis of trichome-less and normal pod genotypes of Mucuna pruriens (Fabaceae)
Authors: S.S. Dhawan, G.K. Rai, M.P. Darokar, R.K. Lal, H.O. Misra and S.P.S. Khanuja
Velvet bean (Mucuna pruriens) seeds contain the catecholic amino acid L-DoPA (L-3,4-dihydroxyphenylalanine), which is a neurotransmitter precursor and used for the treatment of Parkinson’s disease and mental disorders. The great demand for L-DoPA is largely met by the pharmaceutical industry through extraction of the com.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1264
- DOI:
- 10.4238/vol10-3gmr1264
Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in women with locally advanced breast cancer
Authors: F.F.O. Rodrigues, R.E. Santos, M.B. Melo, M.A.L.G. Silva, A.L. Oliveira, R.L. Rozenowicz, L.B. Ulson and T. Aoki
Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associat.. Read More»
- Genet. Mol. Res. 7(1):
A novel SNP of the C/EBP�± gene associated with superior meat quality in indigenous Chinese cattle
Authors: H. Wang, L.S. Zan, H.B. Wang and F.B. Song
CCAAT/enhancer-binding protein alpha (C/EBPa) is an essential transcriptional factor regulating the differentiation of adipocytes. We report a novel single nucleotide polymorphism (C271A) of the C/EBPa gene in six indigenous Chinese cattle breeds using PCR-SSCP and DNA sequencing methods. Allele frequencies were investigated and evaluated by the χ2 te.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1032
- DOI:
- 10.4238/vol10-3gmr1032